Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1964 Jul;43(7):1338–1347. doi: 10.1172/JCI105009

Studies on the Pathogenesis of the Ethanol-induced Fatty Liver. II. Effect of Ethanol on Palmitate-1-C14 Metabolism by the Isolated Perfused Rat Liver*

Robert H Schapiro 1,†, Gladys D Drummey 1, Yoshitaka Shimizu 1, Kurt J Isselbacher 1
PMCID: PMC289609  PMID: 14192514

Full text

PDF
1338

Images in this article

1342Image
on p.1342

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORGSTROM B. Investigation on lipid separation methods. Separation of cholesterol esters, glycerides and free fatty acids. Acta Physiol Scand. 1952 Jun 6;25(2-3):111–119. doi: 10.1111/j.1748-1716.1952.tb00863.x. [DOI] [PubMed] [Google Scholar]
  2. BRAUER R. W., PESSOTTI R. L., PIZZOLATO P. Isolated rat liver preparation; bile production and other basic properties. Proc Soc Exp Biol Med. 1951 Oct;78(1):174–181. doi: 10.3181/00379727-78-19012. [DOI] [PubMed] [Google Scholar]
  3. DAWSON A. M., ISSELBACHER K. J. The esterification of palmitate-1-C14 by homogenates of intestinal mucosa. J Clin Invest. 1960 Jan;39:150–160. doi: 10.1172/JCI104014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DI LUZIO N. R. Effect of acute ethanol intoxication on liver and plasma lipid fractions of the rat. Am J Physiol. 1958 Sep;194(3):453–456. doi: 10.1152/ajplegacy.1958.194.3.453. [DOI] [PubMed] [Google Scholar]
  5. DOLE V. P. A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J Clin Invest. 1956 Feb;35(2):150–154. doi: 10.1172/JCI103259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DOLE V. P., HAMLIN J. T., 3rd Particulate fat in lymph and blood. Physiol Rev. 1962 Oct;42:674–701. doi: 10.1152/physrev.1962.42.4.674. [DOI] [PubMed] [Google Scholar]
  7. ELKO E. E., WOOLES W. R., DI LUZIO N. R. Alterations and mobilization of lipids in acute ethanol-treated rats. Am J Physiol. 1961 Nov;201:923–926. doi: 10.1152/ajplegacy.1961.201.5.923. [DOI] [PubMed] [Google Scholar]
  8. FEIGELSON E. B., PFAFF W. W., KARMEN A., STEINBERG D. The role of plasma free fatty acids in development of fatty liver. J Clin Invest. 1961 Dec;40:2171–2179. doi: 10.1172/JCI104443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  10. FREDRICKSON D. S., GORDON R. S., Jr Transport of fatty acids. Physiol Rev. 1958 Oct;38(4):585–630. doi: 10.1152/physrev.1958.38.4.585. [DOI] [PubMed] [Google Scholar]
  11. HARRIS P. M., ROBINSON D. S. Ethionine administration in the rat. 1. Effects on the liver and plasma lipids and on the disposal of dietary fat. Biochem J. 1961 Aug;80:352–360. doi: 10.1042/bj0800352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HEIMBERG M., MENG H. C., PARK C. R. Effect of sex, fasting and alloxan diabetes on the uptake of neutral fat by isolated perfused rat liver. Am J Physiol. 1958 Dec;195(3):673–677. doi: 10.1152/ajplegacy.1958.195.3.673. [DOI] [PubMed] [Google Scholar]
  13. HILLYARD L. A., CORNELIUS C. E., CHAIKOFF I. L. Removal by the isolated rat liver of palmitate-1-C14 bound to albumin and of palmitate-1-C14 and cholesterol-4-C14 in chylomicrons from perfusion fluid. J Biol Chem. 1959 Sep;234:2240–2245. [PubMed] [Google Scholar]
  14. HORNING M. G., WILLIAMS E. A., MALING H. M., BRODIE B. B. Depot fat as source of increased liver triglycerides after ethanol. Biochem Biophys Res Commun. 1960 Dec;3:635–640. doi: 10.1016/0006-291x(60)90077-2. [DOI] [PubMed] [Google Scholar]
  15. LIEBER C. S., SCHMID R. The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest. 1961 Feb;40:394–399. doi: 10.1172/JCI104266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. LOMBARDI B., RECKNAGEL R. O. Interference with secretion of triglycerides by the liver as a common factor in toxic liver injury with some observations on choline deficiency fatty liver. Am J Pathol. 1962 May;40:571–586. [PMC free article] [PubMed] [Google Scholar]
  17. LOSOWSKY M. S., JONES D. P., DAVIDSON C. S., LIEBER C. S. STUDIES OF ALCOHOLIC HYPERLIPEMIA AND ITS MECHANISM. Am J Med. 1963 Dec;35:794–803. doi: 10.1016/0002-9343(63)90241-9. [DOI] [PubMed] [Google Scholar]
  18. MALING H. M., WAKABAYASHI M., HORNING M. G. ALTERATIONS IN HEPATIC LIPID BIOSYNTHETIC PATHWAYS AFTER ETHANOL, ETHIONINE AND CARBON TETRACHLORIDE. Adv Enzyme Regul. 1963;1:247–257. doi: 10.1016/0065-2571(63)90022-0. [DOI] [PubMed] [Google Scholar]
  19. MALLOV S. Effect of chronic ethanol intoxication on liver lipid content of rats. Proc Soc Exp Biol Med. 1955 Feb;88(2):246–249. doi: 10.3181/00379727-88-21553. [DOI] [PubMed] [Google Scholar]
  20. MALLOV S. Effect of ethanol intoxication on plasma free fatty acids in the rat. Q J Stud Alcohol. 1961 Jun;22:250–253. [PubMed] [Google Scholar]
  21. MILLER L. L., BLY C. G., WATSON M. L., BALE W. F. The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med. 1951 Nov;94(5):431–453. doi: 10.1084/jem.94.5.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. NESTEL P. J., STEINBERG D. FATE OF PALMITATE AND OF LINOLEATE PERFUSED THROUGH THE ISOLATED RAT LIVER AT HIGH CONCENTRATIONS. J Lipid Res. 1963 Oct;4:461–469. [PubMed] [Google Scholar]
  23. REBOUCAS G., ISSELBACHER K. J. Studies on the pathogenesis of the ethanol-induced fatty liver. I. Synthesis and oxidation of fatty acids by the liver. J Clin Invest. 1961 Aug;40:1355–1362. doi: 10.1172/JCI104366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. RECKNAGEL R. O., LOMBARDI B., SCHOTZ M. C. A new insight into pathogenesis of carbon tetrachloride fat infiltration. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:608–610. doi: 10.3181/00379727-104-25923. [DOI] [PubMed] [Google Scholar]
  25. ROBINSON D. S., SEAKINS A. The development in the rat of fatty livers associated with reduced plasma-lipoprotein synthesis. Biochim Biophys Acta. 1962 Jul 30;62:163–165. doi: 10.1016/0006-3002(62)90502-4. [DOI] [PubMed] [Google Scholar]
  26. SMUCKLER E. A., ISERI O. A., BENDITT E. P. An intracellular defect in protein synthesis induced by carbon tetrachloride. J Exp Med. 1962 Jul 1;116:55–72. doi: 10.1084/jem.116.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SPITZER J. A., SPITZER J. J. Effect of liver on lipolysis by normal and post-heparin sera in the rat. Am J Physiol. 1956 Apr;185(1):18–22. doi: 10.1152/ajplegacy.1956.185.1.18. [DOI] [PubMed] [Google Scholar]
  28. VAN HANDEL E., ZILVERSMIT D. B. Micromethod for the direct determination of serum triglycerides. J Lab Clin Med. 1957 Jul;50(1):152–157. [PubMed] [Google Scholar]
  29. ZIEVE L. Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann Intern Med. 1958 Mar;48(3):471–496. doi: 10.7326/0003-4819-48-3-471. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES