Skip to main content
. Author manuscript; available in PMC: 2010 Jul 2.
Published in final edited form as: Tetrahedron. 2009 Jun 27;65(26):4957–4967. doi: 10.1016/j.tet.2009.03.103

Table 3.

NHC-catalyzed cyclization-lactonization of substrate 22.

graphic file with name nihms123358f15.jpg
Entry Catalyst Yield %eea
1 IMesCl 79% -
2 29 75% 5
3 30 50% 9
4 12 78% 9
5 31 73% 23 (40)b

All reactions listed proceeded with 100% conversion.

a

Determined by chiral SFC analysis.

b

Performed at −20 °C.