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. 1964 Oct;43(10):1952–1967. doi: 10.1172/JCI105069

On the Rate of Formation of Steroidal Glucuronosides in Patients with Familial and Acquired Jaundice*

William D Drucker 1,†, Anastasia Sfikakis 1,‡, Abraham J Borkowski 1,§, Nicholas P Christy 1
PMCID: PMC289640  PMID: 14236219

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARIAS I. M. Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults. J Clin Invest. 1962 Dec;41:2233–2245. doi: 10.1172/JCI104682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ARIAS I. M. Ethereal and N-linked glucuronide formation by normal and Gunn rats in vitro and in vivo. Biochem Biophys Res Commun. 1961 Nov 1;6:81–84. doi: 10.1016/0006-291x(61)90388-6. [DOI] [PubMed] [Google Scholar]
  3. ARIAS I. M., FURMAN M., TAPLEY D. F., ROSS J. E. Glucuronide formation and transport of various compounds by Gunn rat intestine in vitro. Nature. 1963 Mar 16;197:1109–1110. doi: 10.1038/1971109a0. [DOI] [PubMed] [Google Scholar]
  4. ARIAS I. M., GARTNER L., FURMAN M., WOLFSON S. Effect of several drugs and chemicals on hepatic glucuronide formation in newborn rats. Proc Soc Exp Biol Med. 1963 Apr;112:1037–1040. doi: 10.3181/00379727-112-28246. [DOI] [PubMed] [Google Scholar]
  5. ARIAS I. M., LONDON I. M. Bilirubin glucuronide formation in vitro; demonstration of a defect in Gilbert's disease. Science. 1957 Sep 20;126(3273):563–564. doi: 10.1126/science.126.3273.563. [DOI] [PubMed] [Google Scholar]
  6. AXELROD J., SCHMID R., HAMMAKER L. A biochemical lesion in congenital, nonobstructive, non-haemolytic jaundice. Nature. 1957 Dec 21;180(4599):1426–1427. doi: 10.1038/1801426a0. [DOI] [PubMed] [Google Scholar]
  7. BECK K., KUHN H. A. Beitrag zur Pathogenese der funktionellen Hyperbilirubinämie. Z Klin Med. 1959;155(6):547–567. [PubMed] [Google Scholar]
  8. BERLINER D. L., STEVENS W., DOUGHERTY T. F. Influence of steroidal structure on glucuronoside formation by mouse liver and kidney. Proc Soc Exp Biol Med. 1962 Jun;110:268–270. doi: 10.3181/00379727-110-27487. [DOI] [PubMed] [Google Scholar]
  9. BILLING B. H., COLE P. G., LATHE G. H. The excretion of bilirubin as a diglucuronide giving the direct van den Bergh reaction. Biochem J. 1957 Apr;65(4):774–784. doi: 10.1042/bj0650774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. BROWN H., WILLARDSON D. G., SAMUELS L. T., TYLER F. H. 17-Hydroxycorticosteroid metabolism in liver disease. J Clin Invest. 1954 Nov;33(11):1524–1532. doi: 10.1172/JCI103031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. BURSTEIN S., LIEBERMAN S. Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures. J Biol Chem. 1958 Aug;233(2):331–335. [PubMed] [Google Scholar]
  12. BUSH I. E. Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. Biochem J. 1952 Jan;50(3):370–378. doi: 10.1042/bj0500370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. CHILDS B., SIDBURY J. B., MIGEON C. J. Glucuronic acid conjugation by patients with familial nonhemolytic jaundice and their relatives. Pediatrics. 1959 May;23(5):903–913. [PubMed] [Google Scholar]
  14. CHRISTY N. P., LONGSON D., HORWITZ W. A., KNIGHT M. M. Inhibitory effect of chlorpromazine upon the adrenal cortical response to insulin hypoglycemia in man. J Clin Invest. 1957 Apr;36(4):543–549. doi: 10.1172/JCI103452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. CHRISTY N. P., WALLACE E. Z., GORDON W. E., JAILER J. W. On the rate of hydrocortisone clearance from plasma in pregnant women and in patients with Laennec's cirrhosis. J Clin Invest. 1959 Feb;38(2):299–305. doi: 10.1172/JCI103802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. COHN G. L., HUME M. The in vivo glucuronide conjugation of radioactive etiocholanolone and androsterone by the dog kidney. J Clin Invest. 1960 Oct;39:1584–1589. doi: 10.1172/JCI104180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. CONNEY A. H., MILLER E. C., MILLER J. A. Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. J Biol Chem. 1957 Oct;228(2):753–766. [PubMed] [Google Scholar]
  18. CONNEY A. H., MILLER E. C., MILLER J. A. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res. 1956 Jun;16(5):450–459. [PubMed] [Google Scholar]
  19. CRIGLER J. F., Jr, NAJJAR V. A. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics. 1952 Aug;10(2):169–180. [PubMed] [Google Scholar]
  20. DICZFALUSY E., FRANKSSON C., LISBOA B. P., MARTINSEN B. Formation of oestrone glucosiduronate by the human intestinal tract. Acta Endocrinol (Copenh) 1962 Aug;40:537–551. doi: 10.1530/acta.0.0400537. [DOI] [PubMed] [Google Scholar]
  21. DUBIN I. N., JOHNSON F. B. Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases. Medicine (Baltimore) 1954 Sep;33(3):155–197. doi: 10.1097/00005792-195409000-00001. [DOI] [PubMed] [Google Scholar]
  22. DUTTON G. J., STEVENSON I. H. The stimulation by 3,4-benzyrene of glucuronide synthesis in skin. Biochim Biophys Acta. 1962 Apr 23;58:633–634. doi: 10.1016/0006-3002(62)90089-6. [DOI] [PubMed] [Google Scholar]
  23. DUTTON G. J. The mechanism of glucuronide formation. Biochem Pharmacol. 1961 Apr;6:65–71. doi: 10.1016/0006-2952(61)90074-0. [DOI] [PubMed] [Google Scholar]
  24. EBERLEIN W. R., BONGIOVANNI A. M. New solvent systems for the resolution of corticosteroids by paper chromatography. Arch Biochem Biophys. 1955 Nov;59(1):90–96. doi: 10.1016/0003-9861(55)90465-3. [DOI] [PubMed] [Google Scholar]
  25. ENGLERT E., Jr, BROWN H., WALLACH S., SIMONS E. L. Metabolism of free and conjugated 17-hydroxycorticosteroids in subjects with liver disease. J Clin Endocrinol Metab. 1957 Dec;17(12):1395–1406. doi: 10.1210/jcem-17-12-1395. [DOI] [PubMed] [Google Scholar]
  26. ENGLERT E., Jr, BROWN H., WILLARDSON D. G., WALLACH S., SIMONS E. L. Metabolism of free and conjugated 17-hydroxycorticosteroids in subjects with uremia. J Clin Endocrinol Metab. 1958 Jan;18(1):36–48. doi: 10.1210/jcem-18-1-36. [DOI] [PubMed] [Google Scholar]
  27. FRANTZ A. G., KATZ F. H., JAILER J. W. 6beta-Hydroxycortisol and other polar corticosteroids: measurement and significance in human urine. J Clin Endocrinol Metab. 1961 Oct;21:1290–1303. doi: 10.1210/jcem-21-10-1290. [DOI] [PubMed] [Google Scholar]
  28. FUKUSHIMA D. K., LEEDS N. S., BRADLOW H. L., KRITCHEVSKY T. H., STOKEM M. B., GALLAGHER T. F. The characterization of four new metabolites of adrenocortical hormones. J Biol Chem. 1955 Jan;212(1):449–460. [PubMed] [Google Scholar]
  29. GALAMBOS J. T., McLAREN J. R. Hepatic uptake defect in patients with "Gilbert's disease". Arch Intern Med. 1963 Feb;111:214–218. doi: 10.1001/archinte.1963.03620260074013. [DOI] [PubMed] [Google Scholar]
  30. Gold N. I., Smith L. L., Moore F. D. CORTISOL METABOLISM IN MAN: OBSERVATIONS OF PATHWAYS, POOL SIZES OF METABOLITES AND RATES OF FORMATION OF METABOLITES. J Clin Invest. 1959 Dec;38(12):2238–2252. doi: 10.1172/JCI104005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. INSCOE J. K., AXELROD J. Some factors affecting glucuronide formation in vitro. J Pharmacol Exp Ther. 1960 Jun;129:128–131. [PubMed] [Google Scholar]
  32. ISSELBACHER K. J., CHRABAS M. F., QUINN R. C. The solubilization and partial purification of a glucuronyl transferase from rabbit liver microsomes. J Biol Chem. 1962 Oct;237:3033–3036. [PubMed] [Google Scholar]
  33. ISSELBACHER K. J. Enzymatic mechanisms of hormone metabolism. II. Mechanism of hormonal glucuronide formation. Recent Prog Horm Res. 1956;12:134-46; discussion, 146-51. [PubMed] [Google Scholar]
  34. MOLLISON P. L., VEALL N. The use of the isotope 51Cr as a label for red cells. Br J Haematol. 1955 Jan;1(1):62–74. doi: 10.1111/j.1365-2141.1955.tb05489.x. [DOI] [PubMed] [Google Scholar]
  35. NADEL E. M., BURSTEIN S., DORFMAN R. I. Isolation of polar reducing corticosteroids from human urine. Arch Biochem Biophys. 1956 Mar;61(1):144–149. doi: 10.1016/0003-9861(56)90326-5. [DOI] [PubMed] [Google Scholar]
  36. PETERSON R. E. Adrenocortical steroid metabolism and adrenal cortical function in liver disease. J Clin Invest. 1960 Feb;39:320–331. doi: 10.1172/JCI104043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. PETERSON R. E., PIERCE C. E., WYNGAARDEN J. B., BUNIM J. J., BRODIE B. B. The physiological disposition and metabolic fate of cortisone in man. J Clin Invest. 1957 Sep;36(9):1301–1312. doi: 10.1172/JCI103528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. PETERSON R. E., SCHMID R. A clinical syndrome associated with a defect in steroid glucuronide formation. J Clin Endocrinol Metab. 1957 Dec;17(12):1485–1488. doi: 10.1210/jcem-17-12-1485. [DOI] [PubMed] [Google Scholar]
  39. SANDBERG A. A., SLAUNWHITE W. R., Jr, ANTONIADES H. N. The binding of steroids and steroid conjugates to human plasma proteins. Recent Prog Horm Res. 1957;13:209–267. [PubMed] [Google Scholar]
  40. SCHMID R. Direct-reacting bilirubin, bilirubin glucuronide, in serum, bile and urine. Science. 1956 Jul 13;124(3211):76–77. doi: 10.1126/science.124.3211.76. [DOI] [PubMed] [Google Scholar]
  41. SILBER R. H., PORTER C. C. Determination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma. Methods Biochem Anal. 1957;4:139–169. doi: 10.1002/9780470110201.ch4. [DOI] [PubMed] [Google Scholar]
  42. SILBER R. H., PORTER C. C. The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma. J Biol Chem. 1954 Oct;210(2):923–932. [PubMed] [Google Scholar]
  43. van LEUSDEN H., BAKKEREN J. A., ZILLIKENF, STOLTELA p-Nitrophenylglucuronide formation by homozygous adult Gunn rats. Biochem Biophys Res Commun. 1962 Feb 20;7:67–69. doi: 10.1016/0006-291x(62)90147-x. [DOI] [PubMed] [Google Scholar]

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