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. 1964 Oct;43(10):1983–1993. doi: 10.1172/JCI105072

Electrophoretic and Immunochemical Demonstration of the Existence of Four Human Pepsinogens*

Irving Kushner 1,†, Wolfgang Rapp 1, Pierre Burtin 1
PMCID: PMC289643  PMID: 14236222

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON A. C., HUMPHREY J. H. Estimation of the size of antigens by gel diffusion methods. Nature. 1959 Jun 6;183(4675):1590–1592. doi: 10.1038/1831590a0. [DOI] [PubMed] [Google Scholar]
  2. FAHEY J. L., McCOY P. F., GOULIAN M. Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins. J Clin Invest. 1958 Feb;37(2):272–284. doi: 10.1172/JCI103606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HERRIOTT R. M. Pepsinogen and pepsin. J Gen Physiol. 1962 Mar;45(4):57–76. [PMC free article] [PubMed] [Google Scholar]
  4. HIRSCHOWITZ B. I. Pepsinogen: its origins, secretion and excretion. Physiol Rev. 1957 Oct;37(4):475–511. doi: 10.1152/physrev.1957.37.4.475. [DOI] [PubMed] [Google Scholar]
  5. RAPP W., ARONSON S. B., BURTIN P., GRABAR P. CONSTITUENTS AND ANTIGENS OF NORMAL HUMAN GASTRIC MUCOSA AS CHARACTERIZED BY ELECTROPHORESIS AND IMMUNOELECTROPHORESIS IN AGAR GEL. J Immunol. 1964 Apr;92:579–595. [PubMed] [Google Scholar]
  6. RYLE A. P., PORTER R. R. Parapepsins: two proteolytic enzymes associated with porcine pepsin. Biochem J. 1959 Sep;73:75–86. doi: 10.1042/bj0730075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. RYLE A. P. Parapepsinogen II: the zymogen of parapepsin II. Biochem J. 1960 Apr;75:145–150. doi: 10.1042/bj0750145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SCHLAMOWITZ M., VARANDANI P. T., WISSLER F. C. Pepsinogen and pepsin: conformational relations, studied by iodination, immunochemical precipitation, and the influence of pepain inhibitor. Biochemistry. 1963 Mar-Apr;2:238–246. doi: 10.1021/bi00902a006. [DOI] [PubMed] [Google Scholar]
  9. SEIJFFERS M. J., SEGAL H. L., MILLER L. L. SEPARATION OF PEPSIN I, PEPSIN II A, PEPSIN II B, AND PEPSIN III FROM HUMAN GASTRIC MUCOSA. Am J Physiol. 1963 Dec;205:1099–1105. doi: 10.1152/ajplegacy.1963.205.6.1099. [DOI] [PubMed] [Google Scholar]
  10. SEIJFFERS M. J., SEGAL H. L., MILLER L. L. SEPARATION OF PEPSINOGEN I, PEPSINOGEN II, AND PEPSINOGEN III FROM HUMAN GASTRIC MUCOSA. Am J Physiol. 1963 Dec;205:1106–1112. doi: 10.1152/ajplegacy.1963.205.6.1106. [DOI] [PubMed] [Google Scholar]
  11. TANG J., TANG K. I. Purification and properties of a zymogen from human gastric mucosa. J Biol Chem. 1963 Feb;238:606–612. [PubMed] [Google Scholar]
  12. TANG J., WOLF S., CAPUTTO R., TRUCCO R. E. Isolation and crystallization of gastricsin from human gastric juice. J Biol Chem. 1959 May;234(5):1174–1178. [PubMed] [Google Scholar]
  13. TAYLOR W. H. Proteinases of the stomach in health and disease. Physiol Rev. 1962 Oct;42:519–553. doi: 10.1152/physrev.1962.42.4.519. [DOI] [PubMed] [Google Scholar]
  14. URIEL J. A method for the direct detection of proteolytic enzymes after electrophoresis in agar gel. Nature. 1960 Dec 3;188:853–854. doi: 10.1038/188853a0. [DOI] [PubMed] [Google Scholar]
  15. VAN VUNAKIS H., LEHRER H. I., ALLISON W. S., LEVINE L. Immunochemical studies on the components of the pepsinogen system. J Gen Physiol. 1963 Jan;46:589–604. doi: 10.1085/jgp.46.3.589. [DOI] [PMC free article] [PubMed] [Google Scholar]

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