Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1965 Nov;44(11):1778–1787. doi: 10.1172/JCI105285

Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gammaG), IgA (gammaA), and IgM (gammaM), and of light polypeptide chains, type K (I) and type L (II).

E M McKelvey, J L Fahey
PMCID: PMC289678  PMID: 4158545

Full text

PDF
1778

Images in this article

1780Image
on p.1780
1781Image
on p.1781

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C. IMMUNOLOGIC ASPECTS OF HODGKIN'S DISEASE. Medicine (Baltimore) 1964 May;43:189–193. doi: 10.1097/00005792-196405000-00001. [DOI] [PubMed] [Google Scholar]
  2. BARTH W. F., WOCHNER R. D., WALDMANN T. A., FAHEY J. L. METABOLISM OF HUMAN GAMMA MACROGLOBULINS. J Clin Invest. 1964 Jun;43:1036–1048. doi: 10.1172/JCI104987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BLAINEY J. D., BREWER D. B., HARDWICKE J., SOOTHILL J. F. The nephrotic syndrome. Diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy. Q J Med. 1960 Apr;29:235–256. [PubMed] [Google Scholar]
  4. COHEN S., FREEMAN T. Metabolic heterogeneity of human gamma-globulin. Biochem J. 1960 Sep;76:475–487. doi: 10.1042/bj0760475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CREYSSEL R., MOREL P., PELLET M., MEDARD J., REVOL L., CROIZAT P. Deficit en gamma-globulines et complications infectieuses des leucémies lymphoīdes chroniques. Sang. 1958;29(5):383–398. [PubMed] [Google Scholar]
  6. EDELMAN G. M., BENACERRAF B. On structural and functional relations between antibodies and proteins of the gamma-system. Proc Natl Acad Sci U S A. 1962 Jun 15;48:1035–1042. doi: 10.1073/pnas.48.6.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FAHEY F. L., LAWRENCE M. E. QUANTITATIVE DETERMINATION OF 6.6 S GAMMA-GLOBULINS, BETA-2A-GLOBULINS AND GAMMA-1-MACROGLOBULINS IN HUMAN SERUM. J Immunol. 1963 Nov;91:597–603. [PubMed] [Google Scholar]
  8. FAHEY J. L., BOGGS D. R. Serum protein changes in malignant diseases. I. The acute leukemias. Blood. 1960 Oct;16:1479–1490. [PubMed] [Google Scholar]
  9. FAHEY J. L. Chromatographic studies of anomalous gamma-, beta2a-, and macroblobulins and normal gamma-globulins in myeloma and macroglobulinemic sera. J Biol Chem. 1962 Feb;237:440–445. [PubMed] [Google Scholar]
  10. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  11. FAHEY J. L., ROBINSON A. G. FACTORS CONTROLLING SERUM GAMMA-GLOBULIN CONCENTRATION. J Exp Med. 1963 Nov 1;118:845–868. doi: 10.1084/jem.118.5.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. FAHEY J. L. STRUCTURAL BASIS FOR THE DIFFERENCES BETWEEN TYPE I AND TYPE II HUMAN GAMMA-GLOBULIN MOLECULES. J Immunol. 1963 Oct;91:448–459. [PubMed] [Google Scholar]
  13. FAHEY J. L. Separation of serum antibody activities by anion-exchange cellulose chromatography. Science. 1960 Feb 19;131(3399):500–501. doi: 10.1126/science.131.3399.500. [DOI] [PubMed] [Google Scholar]
  14. FAHEY J. L. TWO TYPES OF 6.6 S GAMMA-GLOBULINS, BETA-2A-GLOBULINS AND 18 S GAMMA 1-MACROGLOBULINS IN NORMAL SERUM AND GAMMA-MICROGLOBULINS IN NORMAL URINE. J Immunol. 1963 Oct;91:438–447. [PubMed] [Google Scholar]
  15. FIREMAN P., BOESMAN M., GITLIN D. ATAXIA TELANGIECTASIS. A DYSGAMMAGLOBULINAEMIA WITH DEFICIENT GAMMA-1-A (BETA-2-A)-GLOBULIN. Lancet. 1964 May 30;1(7344):1193–1195. doi: 10.1016/s0140-6736(64)91210-3. [DOI] [PubMed] [Google Scholar]
  16. Fahey J. L., Solomon A. TWO TYPES OF gamma-MYELOMA PROTEINS, beta(2A)-MYELOMA PROTEINS, gamma(1)-MACROGLOBULINS, AND BENCE JONES PROTEINS IDENTIFIED BY TWO GROUPS OF COMMON ANTIGENIC DETERMINANTS. J Clin Invest. 1963 Jun;42(6):811–822. doi: 10.1172/JCI104773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. GOLDEN R. L., MILLER D. G., DIAMOND H. D. gamma-Globulin metabolism in chronic lymphocytic leukemia. J Natl Cancer Inst. 1962 Sep;29:443–453. [PubMed] [Google Scholar]
  18. HUMPHREY J. H., PARROTT D. M., EAST J. STUDIES ON GLOBULIN AND ANTIBODY PRODUCTION IN MICE THYMECTOMIZED AT BIRTH. Immunology. 1964 Jul;7:419–439. [PMC free article] [PubMed] [Google Scholar]
  19. KORNGOLD L., LIPARI R. Multiple-myeloma proteins. I. Immunological studies. Cancer. 1956 Jan-Feb;9(1):183–192. doi: 10.1002/1097-0142(195601/02)9:1<183::aid-cncr2820090119>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  20. KORNGOLD L. THE ANTIGENIC RELATIONSHIP OF TWO HUMAN GAMMA 2-GLOBULINS TO THE GAMMA 2-MYELOMA GLOBULINS. Int Arch Allergy Appl Immunol. 1963;23:9–22. doi: 10.1159/000229398. [DOI] [PubMed] [Google Scholar]
  21. LOGRIPPO G. A., WOLFRAM B. R., HAYASHI H. SERUM GLOBULIN DYSCRASIA. LACK OF VIRUS NEUTRALIZING ANTIBODIES IN NORMAL SERUM AND HYPERGAMMAGLOBULINEMIA. JAMA. 1965 Jan 11;191:97–102. doi: 10.1001/jama.1965.03080020025007. [DOI] [PubMed] [Google Scholar]
  22. MIGITA S., PUTNAM F. W. Antigenic relationships of Bence Jones proteins, myeloma globulins, and normal human gama-globulin. J Exp Med. 1963 Jan 1;117:81–104. doi: 10.1084/jem.117.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. MILLER D. G., KARNOFSKY D. A. Immunologic factors and resistance to infection in chronic lymphatic leukemia. Am J Med. 1961 Nov;31:748–757. doi: 10.1016/0002-9343(61)90159-0. [DOI] [PubMed] [Google Scholar]
  24. NOSSAL G. J., ADA G. L., AUSTIN C. M. ANTIGENS IN IMMUNITY. II. IMMUNOGENIC PROPERTIES OF FLAGELLA, POLYMERIZED FLAGELLIN AND FLAGELLIN IN THE PRIMARY RESPONSE. Aust J Exp Biol Med Sci. 1964 Jun;42:283–294. [PubMed] [Google Scholar]
  25. OSSERMAN E. F., LAWLOR D. Immunoelectrophoretic characterization of the serum and urinary proteins in plasma cell myeloma and Waldenstrom's macroglobulinemia. Ann N Y Acad Sci. 1961 Aug 31;94:93–109. doi: 10.1111/j.1749-6632.1961.tb35535.x. [DOI] [PubMed] [Google Scholar]
  26. PARONETTO F., SCHAFFNER F., POPPER H. IMMUNOCYTOCHEMICAL AND SEROLOGIC OBSERVATIONS IN PRIMARY BILIARY CIRRHOSIS. N Engl J Med. 1964 Nov 26;271:1123–1128. doi: 10.1056/NEJM196411262712201. [DOI] [PubMed] [Google Scholar]
  27. PETERSON R. D., KELLY W. D., GOOD R. A. ATAXIA-TELANGIECTASIA. ITS ASSOCIATION WITH A DEFECTIVE THYMUS, IMMUNOLOGICAL-DEFICIENCY DISEASE, AND MALIGNANCY. Lancet. 1964 May 30;1(7344):1189–1193. doi: 10.1016/s0140-6736(64)91209-7. [DOI] [PubMed] [Google Scholar]
  28. PRASAD A. The association of hypogammaglobulinemia and chronic lymphatic leukemia. Am J Med Sci. 1958 Nov;236(5):610–passim. [PubMed] [Google Scholar]
  29. ROCKEY J. H., HANSON L. A., HEREMANS J. F., KUNKEL H. G. BETA-2A AGLOBULINEMIA IN TWO HEALTHY MEN. J Lab Clin Med. 1964 Feb;63:205–212. [PubMed] [Google Scholar]
  30. SELL S., FAHEY J. L. RELATIONSHIP BETWEEN GAMMA-GLOBULIN METABOLISM AND LOW SERUM GAMMA-GLOBULIN IN GERMFREE MICE. J Immunol. 1964 Jul;93:81–87. [PubMed] [Google Scholar]
  31. SOLOMON A., WALDMANN T. A., FAHEY J. L. Clinical and experimental metabolism of normal 6.6s gamma-globulin in normal subjects and in patients with macroglobulinemia and multiple myeloma. J Lab Clin Med. 1963 Jul;62:1–17. [PubMed] [Google Scholar]
  32. ULTMANN J. E., FISH W., OSSERMAN E., GELLHORN A. The clinical implications of hypogammaglobul inemia in patients with chronic lymphocytic leukemia and lymphocytic lymphosarcoma. Ann Intern Med. 1959 Sep;51:501–516. doi: 10.7326/0003-4819-51-3-501. [DOI] [PubMed] [Google Scholar]
  33. WEST C. D., HONG R., HOLLAND N. H. Immunoglobulin levels from the newborn period to adulthood and in immunoglobulin deficiency states. J Clin Invest. 1962 Nov;41:2054–2064. doi: 10.1172/JCI104663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. YOUNG R. R., AUSTEN K. F., MOSER H. W. ABNORMALITIES OF SERUM GAMMA-1-A GLOBULIN AND ATAXIA TELANGIECTASIA. Medicine (Baltimore) 1964 May;43:423–433. doi: 10.1097/00005792-196405000-00021. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES