Table 4.
Non-Dose Limiting Non-Hematologic toxicities related to protocol therapy and observed in more than 10 percent of 13 evaluable patients.
| Course 1 (n=13) |
Courses 2 to 6 (n=14) |
|||||
|---|---|---|---|---|---|---|
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 1 | Grade 2 | Grade 3 |
| Fatigue | 2 | 1 | ||||
| Weight loss | 4 | 1 | ||||
| Anorexia | 1 | 3 | 1 | 3 | ||
| Dehydration | 5 | 1 | ||||
| Diarrhea | 4 | 2 | 1 | 4 | 2 | |
| Nausea | 1 | 2 | 1 | 1 | 1 | 1 |
| Vomiting | 2 | 2 | 1 | 1 | 2 | 1 |
| Paresthesia/dysesthesia | 2 | |||||
| Pancreatitis | 1 | 1 | 1 | |||
| Hypoalbuminemia | 1 | 2 | 2 | |||
| ALT, SGPT | 3 | 1 | 1 | 2 | 1 | |
| AST, SGOT | 2 | 1 | 2 | |||
| Hypocalcemia | 2 | 1 | 2 | 2 | ||
| GGT | 1 | 1 | 1 | 1 | ||
| Lipase | 2 | 2 | ||||
| Hypomagnesemia | 2 | 1 | 1 | |||
| Hypokalemia | 2 | 1 | ||||
| Pain Abdomen NOS | 2 | 2 | 2 | |||