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Models of a steric switch designed at the Gαi1 (green) and GoLoco (blue) interface (design #1). A) Wild type interface. B) The mutation V507M is predicted to create a clash at the interface that is accommodated by L249A (panel C). D) Binding curves as measured by fluorescence polarization, Gαi1 was titrated into GoLoco labeled with fluorescein.
