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Interaction Between Family History (FH) and Estrogen Plus Progesterone (EP) on the Risk of Invasive Breast Cancer
| Strata of Family History by Estrogen Plus Progesterone Replacement |
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|---|---|---|---|---|
| FH1EP1 | FH1EP0 | FH0EP1 | FH0EP0 | |
| No. cases | 35 | 25 | 164 | 125 |
| No. women | 1009 | 895 | 7497 | 7207 |
| Risk | 0.035 | 0.028 | 0.022 | 0.017 |
| Interaction contrast (IC) | = (RFH = 1, EP = 1 – RFH = 1, EP = 0) – (RFH = 0, EP = 1 – RFH = 0, EP = 0) = (0.035 – 0.028) – (0.022 – 0.017) = 0.002 (95% CI = −0.014 to 0.018) |
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