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Sensitivities of 19 AML cell lines to MI219. Nineteen AML cell lines (Table 2) were incubated for 40 hours with various concentrations of MI-219. Samples were prepared for annexin V and PI staining and analyzed by flow cytometry, and the residual live and nonapoptotic cell fraction was calculated for each concentration by comparison with the untreated control incubation. Red represents p53 sequence mutants; and black, wild-type p53 status.
