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. 1961 Apr;40(4):617–623. doi: 10.1172/JCI104292

THE EFFECT OF VITAMIN SUPPLEMENTATION ON THE URINARY EXCRETION OF TRYPTOPHAN METABOLITES BY PREGNANT WOMEN*

R R Brown 1, Madeline J Thornton 1, J M Price 1,
PMCID: PMC290765  PMID: 16695856

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN R. R., PRICE J. M. Quantitative studies on human urinary metabolites of D-, DL-, acetyl-L-, and acetyl-D-tryptophan. J Biol Chem. 1956 Oct;222(2):835–842. [PubMed] [Google Scholar]
  2. BROWN R. R., PRICE J. M. Quantitative studies on metabolites of tryptophan in the urine of the dog, cat, rat, and man. J Biol Chem. 1956 Apr;219(2):985–997. [PubMed] [Google Scholar]
  3. BROWN R. R. The isolation and determination of urinary hydroxykynurenine. J Biol Chem. 1957 Aug;227(2):649–652. [PubMed] [Google Scholar]
  4. CIVEN M., KNOX W. E. The independence of hydrocortisone and tryptophan inductions of tryptophan pyrrolase. J Biol Chem. 1959 Jul;234(7):1787–1790. [PubMed] [Google Scholar]
  5. DALGLIESH C. E. The relation between pyridoxin and tryptophan metabolism, studied in the rat. Biochem J. 1952 Sep;52(1):3–14. doi: 10.1042/bj0520003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DODGE L. W., PRICE J. M. Occurrence of the 8-methyl ether of xanthurenic acid in normal human urine. J Biol Chem. 1956 Dec;223(2):699–704. [PubMed] [Google Scholar]
  7. GLAZER H. S., MUELLER J. F., THOMPSON C., HAWKINS V. R., VILTER R. W. A study of urinary excretion of xanthurenic acid and other tryptophan metabolites in human beings with pyridoxine deficiency induced by desoxypyridoxine. Arch Biochem Biophys. 1951 Sep;33(2):243–251. doi: 10.1016/0003-9861(51)90102-6. [DOI] [PubMed] [Google Scholar]
  8. KNOX W. E. The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. Biochem J. 1953 Feb;53(3):379–385. doi: 10.1042/bj0530379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MASON M., BERG C. P. The metabolism of d- and l-tryptophan and d- and l-kynurenine by liver and kidney preparations. J Biol Chem. 1952 Apr;195(2):515–524. [PubMed] [Google Scholar]
  10. MASON M., GULLEKSON E. H. Estrogen-enzyme interactions: Inhibition and protection of kynurenine transaminase by the sulfate esters of diethylstilbestrol, estradiol, and estrone. J Biol Chem. 1960 May;235:1312–1316. [PubMed] [Google Scholar]
  11. MEHLER A. H., McDANIEL E. G., HUNDLEY J. M. Changes in the enzymatic composition of liver. II. Influence of hormones on picolinic carboxylase and tryptophan peroxidase. J Biol Chem. 1958 May;232(1):331–335. [PubMed] [Google Scholar]
  12. PAGE E. W. The vitamin B6 requirement for normal pregnancy. West J Surg Obstet Gynecol. 1956 Feb;64(2):96–103. [PubMed] [Google Scholar]
  13. PRICE J. M., BROWN R. R., LARSON F. C. Quantitative studies on human urinary metabolites of tryptophan as affected by isoniazid and deoxypyridoxine. J Clin Invest. 1957 Nov;36(11):1600–1607. doi: 10.1172/JCI103559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. ROSEN F., ROBERTS N. R., NICHOL C. A. Glucocorticosteroids and transaminase activity. I. Increased activity of glutamicpyruvic transaminase in four conditions associated with gluconeogenesis. J Biol Chem. 1959 Mar;234(3):476–480. [PubMed] [Google Scholar]
  15. SATOH K., PRICE J. M. Fluorometric determination of kynurenic acid and xanthurenic acid in human urine. J Biol Chem. 1958 Feb;230(2):781–789. [PubMed] [Google Scholar]
  16. SPRINCE H., LOWY R. S., FOLSOME C. E., BEHRMAN J. S. Studies on the urinary excretion of "xanthurenic acid" during normal and abnormal pregnancy: a survey of the excretion of "xanthurenic acid" in normal nonpregnant, normal pregnant, pre-eclamptic, and eclamptic women. Am J Obstet Gynecol. 1951 Jul;62(1):84–92. doi: 10.1016/0002-9378(51)91093-9. [DOI] [PubMed] [Google Scholar]
  17. VANDELLI I., GINOULHIAC E., TENCONI L. T. La eliminazione urinaria di acido xanturenico dopo carico di triptofano in rapporto a diverse condizioni ormonali. Ann Ostet Ginecol. 1955 Mar;77(3):324–328. [PubMed] [Google Scholar]
  18. WACHSTEIN M., GRAFFEO L. W. Influence of vitamin B6 on the incidence of preeclampsia. Obstet Gynecol. 1956 Aug;8(2):177–180. [PubMed] [Google Scholar]
  19. WACHSTEIN M., GUDAITIS A. Detection of vitamin B6 deficiency; utilization of an improved method for rapid determination of xanthurenic acid in urine. Am J Clin Pathol. 1952 Jul;22(7):652–655. doi: 10.1093/ajcp/22.7.652. [DOI] [PubMed] [Google Scholar]
  20. WACHSTEIN M., GUDAITIS A. Disturbance of vitamin B6 metabolism in pregnancy. II. The influence of various amounts of pyridoxine hydrochloride upon the abnormal tryptophane load test in pregnant women. J Lab Clin Med. 1953 Jul;42(1):98–107. [PubMed] [Google Scholar]
  21. WACHSTEIN M., LOBEL S. Abnormal tryptophan metabolites in human pregnancy and their relation to deranged vitamin B6 metabolism. Proc Soc Exp Biol Med. 1954 Jul;86(3):624–627. doi: 10.3181/00379727-86-21183. [DOI] [PubMed] [Google Scholar]
  22. WALTERS C. J., BROWN R. R., KAIHARA M., PRICE J. M. The excretion of N-methyl-2-pyridone-5-carboxamide by man following ingestion of several known or potential precursors. J Biol Chem. 1955 Nov;217(1):489–495. [PubMed] [Google Scholar]
  23. WERTZ A. W., LOJKIN M. E., BOUCHARD B. S., DERBY M. B. Tryptophan-niacin relationships in pregnancy. J Nutr. 1958 Mar 10;64(3):339–353. doi: 10.1093/jn/64.3.339. [DOI] [PubMed] [Google Scholar]
  24. ZARTMAN E. R., BARNES A. C., HICKS D. J. Observations on pyridoxine metabolism in pregnancy. Am J Obstet Gynecol. 1955 Sep;70(3):645–649. doi: 10.1016/0002-9378(55)90360-4. [DOI] [PubMed] [Google Scholar]

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