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. 1961 Nov;40(11):2076–2082. doi: 10.1172/JCI104433

A QUANTITATIVE STUDY OF RECYCLING OF ISOTOPE FROM GLYCINE-1-C14,α-N15 INTO VARIOUS SUBUNITS OF THE URIC ACID MOLECULE IN A NORMAL SUBJECT*

R Rodney Howell 1,2,3,†, Melinda Speas 1,2,3, James B Wyngaarden 1,2,3
PMCID: PMC290911  PMID: 14449402

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARNSTEIN H. R. V., NEUBERGER A. Hippuric acid synthesis in the rat. Biochem J. 1951 Dec;50(2):154–162. doi: 10.1042/bj0500154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BENEDICT J. D., KALINSKY H. J., SCARRONE L. A., WERTBEIM A. R., STETTEN D., Jr The origin of urinary creatine in progressive muscular dystrophy. J Clin Invest. 1955 Jan;34(1):141–145. doi: 10.1172/JCI103057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BERLIN N. I., HEWITT C., LOTZ C. Hippuric acid synthesis in man after the administration of [alpha-14C]Glycine. Biochem J. 1954 Nov;58(3):498–503. doi: 10.1042/bj0580498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BRANDENBERGER H. The oxidation of uric acid to oxonic acid (allantoxanic acid) and its application in tracer studies of uric acid biosynthesis. Biochim Biophys Acta. 1954 Sep;15(1):108–116. doi: 10.1016/0006-3002(54)90099-2. [DOI] [PubMed] [Google Scholar]
  5. CAMMARATA P. S., COHEN P. P. The scope of the transamination reaction in animal tissues. J Biol Chem. 1950 Nov;187(1):439–452. [PubMed] [Google Scholar]
  6. CRADDOCK C. G., Jr, PERRY S., LAWRENCE J. S. The dynamics of leukopenia and leukocytosis. Ann Intern Med. 1960 Feb;52:281–294. doi: 10.7326/0003-4819-52-2-281. [DOI] [PubMed] [Google Scholar]
  7. ELWYN D., WEISSBACH A., HENRY S. S., SPRINSON D. B. The biosynthesis of choline from serine and related compounds. J Biol Chem. 1955 Mar;213(1):281–295. [PubMed] [Google Scholar]
  8. GRAY C. H., NEUBERGER A. Studies in congenital porphyria. I. Incorporation of 15N into coproporphyrin, uroporphyrin and hippuric acid. Biochem J. 1950 Jun-Jul;47(1):81–87. doi: 10.1042/bj0470081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GUTMAN A. B., YU T. F., BLACK H., YALOW R. S., BERSON S. A. Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Am J Med. 1958 Dec;25(6):917–932. doi: 10.1016/0002-9343(58)90063-9. [DOI] [PubMed] [Google Scholar]
  10. HEINRICH M. R., WILSON D. W. The biosynthesis of nucleic acid components studied with C14. I. Purines and pyrimidines in the rat. J Biol Chem. 1950 Oct;186(2):447–460. [PubMed] [Google Scholar]
  11. KUN E., DECHARY J. M., PITOT H. C. The oxidation of glycolic acid by a liver enzyme. J Biol Chem. 1954 Sep;210(1):269–280. [PubMed] [Google Scholar]
  12. LEVENBERG B., HARTMAN S. C., BUCHANAN J. M. Biosynthesis of the purines. X. Further studies in vitro on the metabolic origin of nitrogen atoms 1 and 3 of the purine ring. J Biol Chem. 1956 May;220(1):379–390. [PubMed] [Google Scholar]
  13. MOORE S., STEIN W. H. Chromatography of amino acids on sulfonated polystyrene resins. J Biol Chem. 1951 Oct;192(2):663–681. [PubMed] [Google Scholar]
  14. NAKADA H. I., SUND L. P. Glyoxylic acid oxidation by rat liver. J Biol Chem. 1958 Jul;233(1):8–13. [PubMed] [Google Scholar]
  15. NAKADA H. I., WEINHOUSE S. Studies of glycine oxidation in rat tissues. Arch Biochem Biophys. 1953 Feb;42(2):257–270. doi: 10.1016/0003-9861(53)90356-7. [DOI] [PubMed] [Google Scholar]
  16. NEMETH A. M., RUSSELL C. S., SHEMIN D. The succinate-glycine cycle. II. Metabolism of delta-aminolevulinic acid. J Biol Chem. 1957 Nov;229(1):415–422. [PubMed] [Google Scholar]
  17. Robinson C. V. Windowless, Flow Type, Proportional Counter for Counting C14. Science. 1950 Aug 18;112(2903):198–199. doi: 10.1126/science.112.2903.198. [DOI] [PubMed] [Google Scholar]
  18. SONNE J. C., LIN I., BUCHANAN J. M. Biosynthesis of the purines. IX. Precursors of the nitrogen atoms of the purine ring. J Biol Chem. 1956 May;220(1):369–378. [PubMed] [Google Scholar]
  19. WATTS R. W., CRAWHALL J. C. The first glycine metabolic pool in man. Biochem J. 1959 Oct;73:277–286. doi: 10.1042/bj0730277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WEINHOUSE S., FRIEDMANN B. Metabolism of labeled 2-carbon acids in the intact rat. J Biol Chem. 1951 Aug;191(2):707–717. [PubMed] [Google Scholar]
  21. WYNGAARDEN J. B. Overproduction of uric acid as the cause of hyperuricemia in primary gout. J Clin Invest. 1957 Oct;36(10):1508–1515. doi: 10.1172/JCI103547. [DOI] [PMC free article] [PubMed] [Google Scholar]

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