Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1962 Mar;41(3):420–446. doi: 10.1172/JCI104496

THE REJECTION OF SKIN HOMOGRAFTS IN THE NORMAL HUMAN SUBJECT. PART II. HISTOLOGICAL FINDINGS

Laurence Henry 1,2,3, David C Marshall 1,2,3, Eli A Friedman 1,2,3, Gustave J Dammin 1,2,3, John P Merrill 1,2,3
PMCID: PMC290936  PMID: 13906552

Full text

PDF
420

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALGIRE G. H., WEAVER J. M., PREHN R. T. Growth of cells in vivo in diffusion chambers. I. Survival of homografts in immunized mice. J Natl Cancer Inst. 1954 Dec;15(3):493–507. [PubMed] [Google Scholar]
  2. ALGIRE G. H., WEAVER J. M., PREHN R. T. Studies on tissue homotransplantation in mice, using diffusion-chamber methods. Ann N Y Acad Sci. 1957 Mar 22;64(5):1009–1013. doi: 10.1111/j.1749-6632.1957.tb52492.x. [DOI] [PubMed] [Google Scholar]
  3. AMOS D. B., GORER P. A., MIKULSKA Z. B. An analysis of an antigenic system in the mouse (the H-2 system). Proc R Soc Lond B Biol Sci. 1955 Nov 29;144(916):369–380. doi: 10.1098/rspb.1955.0064. [DOI] [PubMed] [Google Scholar]
  4. BAUER J. A., Jr Histocompatibility in inbred strains of guinea pigs. Ann N Y Acad Sci. 1958 Oct 7;73(3):663–672. doi: 10.1111/j.1749-6632.1959.tb40842.x. [DOI] [PubMed] [Google Scholar]
  5. BILLINGHAM R. E., BRENT L., BROWN J. B., MEDAWAR P. B. Time of onset and duration of transplantation immunity. Transplant Bull. 1959 Oct;6:410–414. doi: 10.1097/00006534-195910000-00035. [DOI] [PubMed] [Google Scholar]
  6. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. The antigenic stimulus in transplantation immunity. Nature. 1956 Sep 8;178(4532):514–519. doi: 10.1038/178514a0. [DOI] [PubMed] [Google Scholar]
  7. CONVERSE J. M., RAPAPORT F. T. The vascularization of skin autografts and homografts; an experimental study in man. Ann Surg. 1956 Mar;143(3):306–315. doi: 10.1097/00000658-195603000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DAMMIN G. J., COUCH N. P., MURRAY J. E. Prolonged survival of skin homografts in uremic patients. Ann N Y Acad Sci. 1957 Mar 22;64(5):967–976. doi: 10.1111/j.1749-6632.1957.tb52488.x. [DOI] [PubMed] [Google Scholar]
  9. DAMMIN G. J., MURRAY J. E. Criteria for acceptance of skin grafts. Transplant Bull. 1959 Oct;6:429–432. doi: 10.1097/00006534-195910000-00041. [DOI] [PubMed] [Google Scholar]
  10. FRIEDMAN E. A., RETAN J. W., MARSHALL D. C., HENRY L., MERRILL J. P. Accelerated skin graft rejection in humans preimmunized with homologous peripheral leukocytes. J Clin Invest. 1961 Dec;40:2162–2170. doi: 10.1172/JCI104442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GELL P. G. H., HINDE I. T. The histology of the tuberculin reaction and its modification by cortisone. Br J Exp Pathol. 1951 Dec;32(6):516–529. [PMC free article] [PubMed] [Google Scholar]
  12. GELL P. G., HINDE I. T. Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. Int Arch Allergy Appl Immunol. 1954;5(1):23–46. doi: 10.1159/000228084. [DOI] [PubMed] [Google Scholar]
  13. GREEN I., CORSO P. F. A study of skin homografting in patients with lymphomas. Blood. 1959 Mar;14(3):235–245. [PubMed] [Google Scholar]
  14. Gibson T., Medawar P. B. The fate of skin homografts in man. J Anat. 1943 Jul;77(Pt 4):299–310.4. [PMC free article] [PubMed] [Google Scholar]
  15. HENRY L., MARSHALL D. C., FRIEDMAN E. A., GOLDSTEIN D. P., DAMMIN G. J. A histological study of the human skin graft. Am J Pathol. 1961 Sep;39:317–332. [PMC free article] [PubMed] [Google Scholar]
  16. HILDEMANN W. H. A method for detecting hemolysins in mouse isoimmune serums. Transplant Bull. 1957 Oct;4(4):148–149. [PubMed] [Google Scholar]
  17. HILDEMANN W. H., MEDAWAR P. B. Relationship between skin transplantation immunity and the formation of humoral isoantibodies in mice. Immunology. 1959 Jan;2(1):44–52. [PMC free article] [PubMed] [Google Scholar]
  18. KAY G. D. Prolonged survival of a skin homograft in a patient with very extensive burns. Ann N Y Acad Sci. 1957 Mar 22;64(5):767–774. doi: 10.1111/j.1749-6632.1957.tb52471.x. [DOI] [PubMed] [Google Scholar]
  19. LAWRENCE H. S., RAPAPORT F. T., CONVERSE J. M., TILLETT W. S. Transfer of delayed hypersensitivity to skin homografts with leukocyte extracts in man. J Clin Invest. 1960 Jan;39:185–198. doi: 10.1172/JCI104018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. LAWRENCE H. S. Similarities between homograft rejection and tuberculin-type allergy: a review of recent experimental findings. Ann N Y Acad Sci. 1957 Mar 22;64(5):826–835. doi: 10.1111/j.1749-6632.1957.tb52476.x. [DOI] [PubMed] [Google Scholar]
  21. LEHRFELD J. W., TAYLOR A. C., CONVERSE J. M. Observations on second and third set skin homografts in the rat. Plast Reconstr Surg (1946) 1955 Jan;15(1):74–76. doi: 10.1097/00006534-195501000-00010. [DOI] [PubMed] [Google Scholar]
  22. LEHRFELD J. W., TAYLOR A. C. The dosage phenomenon in rat skin homografts. Plast Reconstr Surg (1946) 1953 Dec;12(6):432–438. doi: 10.1097/00006534-195312000-00006. [DOI] [PubMed] [Google Scholar]
  23. LEJEUNE-LEDANT G. N., ALBERT F. H. Preparation of a transplantation antigen from epidermal cells. Ann N Y Acad Sci. 1960 May 31;87:308–322. doi: 10.1111/j.1749-6632.1960.tb23203.x. [DOI] [PubMed] [Google Scholar]
  24. MAJNO G., PALADE G. E., SCHOEFL G. I. Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: a topographic study. J Biophys Biochem Cytol. 1961 Dec;11:607–626. doi: 10.1083/jcb.11.3.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. MANN L. T., Jr, CORSON J. M., DAMMING G. J. Method for the study of antigenicity of homologous whole spleen cells in mice. Science. 1959 Dec 18;130(3390):1707–1708. doi: 10.1126/science.130.3390.1707. [DOI] [PubMed] [Google Scholar]
  26. MARSHALL A. H. E., WHITE R. G. Reactions of the reticular tissues to antigens. Br J Exp Pathol. 1950 Apr;31(2):157–174. [PMC free article] [PubMed] [Google Scholar]
  27. MERRILL J. P., FRIEDMAN E. A., WILSON R. E., MARSHALL D. C. The production of "delayed type" cutaneous hypersensitivity to human donor leukocytes as a result of the rejection of skin homografts. J Clin Invest. 1961 Apr;40:631–635. doi: 10.1172/JCI104294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. MERWIN R. M., HILL E. L. Fate of vascularized and nonvascularized subcutaneous homografts in mice. J Natl Cancer Inst. 1954 Feb;14(4):819–839. [PubMed] [Google Scholar]
  29. McKhann C. F. Studies of the Dermis in Skin Homografts. Ann Surg. 1960 Aug;152(2):284–289. doi: 10.1097/00000658-196008000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Medawar P. B. The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council. J Anat. 1944 Oct;78(Pt 5):176–199. [PMC free article] [PubMed] [Google Scholar]
  31. PREHN R. T., WEAVER J. M., ALGIRE G. H. The diffusion-chamber technique applied to a study of the nature of homograft resistance. J Natl Cancer Inst. 1954 Dec;15(3):509–517. [PubMed] [Google Scholar]
  32. RAPAPORT F. T., CONVERSE J. M. The immune response to multiple-set skin homografts: an experimental study in man. Ann Surg. 1958 Mar;147(3):273–280. doi: 10.1097/00000658-195803000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. RAPAPORT F. T., THOMAS L., CONVERSE J. M., LAWRENCE H. S. The specificity of skin homograft rejection in man. Ann N Y Acad Sci. 1960 May 31;87:217–222. doi: 10.1111/j.1749-6632.1960.tb23195.x. [DOI] [PubMed] [Google Scholar]
  34. RAUCH H. C., FAVOUR C. B. Passive transfer of allergic reactions to tuberculin with plasma protein fractions from hypersensitive guinea pigs. Ann N Y Acad Sci. 1960 May 31;87:231–248. doi: 10.1111/j.1749-6632.1960.tb23197.x. [DOI] [PubMed] [Google Scholar]
  35. ROGERS B. O., CONVERSE J. M., TAYLOR A. C., CAMPBELL R. M. Eosinophile in human skin homografting. Proc Soc Exp Biol Med. 1953 Mar;82(3):523–526. doi: 10.3181/00379727-82-20167. [DOI] [PubMed] [Google Scholar]
  36. SCOTHORNE R. J., MCGREGOR I. A. Cellular changes in lymph nodes and spleen following skin homografting in the rabbit. J Anat. 1955 Jul;89(3):283–292. [PMC free article] [PubMed] [Google Scholar]
  37. SCOTHORNE R. J. Studies on the response of the regional lymph node to skin homografts. Ann N Y Acad Sci. 1957 Mar 22;64(5):1028-38; discussion, 1038-9. doi: 10.1111/j.1749-6632.1957.tb52494.x. [DOI] [PubMed] [Google Scholar]
  38. SELBY C. C. An electron microscope study of the epidermis of mammalian skin in thin sections. I. Dermo-epidermal junction and basal cell layer. J Biophys Biochem Cytol. 1955 Sep 25;1(5):429–444. doi: 10.1083/jcb.1.5.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. STETSON C. A., Jr, DEMOPOULOS R. Reactions of skin homografts with specific immune sera. Ann N Y Acad Sci. 1958 Oct 7;73(3):687–692. doi: 10.1111/j.1749-6632.1959.tb40845.x. [DOI] [PubMed] [Google Scholar]
  40. TERASAKI P. I., CANNON J. A., LONGMIRE W. P., Jr, CHAMBERLAIN C. C. Antibody response to homografts: V. Cytotoxic effects upon lymphocytes as measured by time-lapse cinematography. Ann N Y Acad Sci. 1960 May 31;87:258–265. doi: 10.1111/j.1749-6632.1960.tb23199.x. [DOI] [PubMed] [Google Scholar]
  41. WOODRUFF M. F. Cellular and humoral factors in the immunity to skin homografts: experiments with a porous membrane. Ann N Y Acad Sci. 1957 Mar 22;64(5):1014-26; discussion, 1026-7. doi: 10.1111/j.1749-6632.1957.tb52493.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES