Table 2.

Demographics and homocysteine at baseline and changes

	Preexisting condition	Patients	Age, years	Men, %	Previous stroke, %	DM, %	Baseline Hcy, μmol/L	Hcy reduction, %
Mark 1996³⁴	Esophageal dysplasia	3318	54	44	NR	NR	NR	NR
Liem 2004³⁵	Acute MI	283	59	70	NR	24	NR	NR
Toole 2004³⁷	Ischemic stroke	3680	66.3±10.8	63	100	29	13.4	14.0
Wrone 2004³⁸	ESRD	510	60.2±15.1	50	NR	45	33.0±20.4	20.0
Leim 2005³⁶	CHD	593	65.2±9.8	78	7	9	12.1±4.3	21.7
Bonaa 2006³⁹	Acute MI	2815	63.2 ±11.6	74	4	10	13.1±4.8	28.7
Lonn 2006⁴⁰	Vascular disease or multiple risk factors for atherosclerosis	5522	68.9±6.9	71	9	40	12.2±1.6	24.8
Righetti 2006⁴¹	ESRD	88	64.5±1.8	56	NR	19	34.9±1.4	34.3
Zoungas 2006⁴²	ESRD	315	56±13	68	9	23	27±13	10.0
Jamison 2007¹⁹	ESRD and ACKD	2056	65.8±11.7	98	15	55	22.4 (18.7-27.3)	34.6
Albert 2008¹⁷	CVD or multiple risk factors for atherosclerosis	5442	62.8±8.8	0	NR	21	12.3 (9.6-15.5)	18.5
Ebbing 2008¹⁸	CHD and/or aortic valve stenosis	2319	61.7±10.1	79	6	12	10.8±4.5	26
Collins 2008⁴³	MI	12064	64±9	83	7	11	13.5±5	28

DM: diabetes mellitus; Hcy: homocysteine; MI: myocardial infarct; CVD: cardiovascular disease; CHD: coronary heart disease; ESRD: end-stage renal disease; ACKD: advanced chronic kidney disease; NR: not reported