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. 1962 Apr;41(4):758–769. doi: 10.1172/JCI104534

THE ROLE OF THE ENDOCRINE GLANDS IN KETOSIS. II. KETONEMIA FOLLOWING INSULIN HYPOGLYCEMIA*

Thomas T Amatruda Jr 1,2,3,4,†, Joan W Chase 1,2,3,4, Frank L Engel 1,2,3,4
PMCID: PMC290979  PMID: 13860888

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMATRUDA T. T., Jr, ENGEL F. L. The role of the endocrine glands in ketosis. I. The ketosis of fasting. Yale J Biol Med. 1959 Apr;31(5):303–323. [PMC free article] [PubMed] [Google Scholar]
  2. BARRETO H. P., RECANT L. Failure of hypophysectomy, adrenalectomy or thyroidectomy to affect response of nonesterified fatty acids to fasting. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:627–629. doi: 10.3181/00379727-104-25930. [DOI] [PubMed] [Google Scholar]
  3. BEATTY C. H., PETERSON R. D., BOCEK R. M., WEST E. S. Acetoacetate and glucose uptake by diaphragm and skeletal muscle from from control and diabetic rats. J Biol Chem. 1959 Jan;234(1):11–15. [PubMed] [Google Scholar]
  4. BEIGELMAN P. M., GOETZ F. C., ANTONIADES H. N., THORN G. W. Insulin-like activity of human plasma constituents. I. Description and evaluation of biologic assay for insulin-like activity. Metabolism. 1956 Jan;5(1):35–43. [PubMed] [Google Scholar]
  5. BIERMAN E. L., SCHWARTZ I. L., DOLE V. P. Action of insulin on release of fatty acids from tissue stores. Am J Physiol. 1957 Nov;191(2):359–362. doi: 10.1152/ajplegacy.1957.191.2.359. [DOI] [PubMed] [Google Scholar]
  6. BLISS E. L., MIGEON C. J., EIK-NES K., SANDBERG A. A., SAMUELS L. T. The effects of insulin, histamine, bacterial pyrogen, and the antabuse-alcohol reaction upon the levels of 17-hydroxycorticosteroids in the peripheral blood of man. Metabolism. 1954 Nov;3(6):493–501. [PubMed] [Google Scholar]
  7. BONDY P. K., CARDILLO L. R. The effect of glucagon on carbohydrate metabolism in normal human beings. J Clin Invest. 1956 May;35(5):494–501. doi: 10.1172/JCI103302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. BONDY P. K., WILHELMI A. E. Effect of hormones upon the production of ketone bodies by rat liver slices. J Biol Chem. 1950 Sep;186(1):245–251. [PubMed] [Google Scholar]
  9. Best C. H., Haist R. E. The effect of insulin administration on the insulin content of the pancreas. J Physiol. 1941 Sep 8;100(2):142–146. doi: 10.1113/jphysiol.1941.sp003930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. CAMPBELL J., BEST C. H. Physiologic aspects of ketosis. Metabolism. 1956 Mar;5(2):95–113. [PubMed] [Google Scholar]
  11. ENGEL F. L., HEWSON K. Fatty acid and ketone metabolism during hemorrhage and shock in the rat. Proc Soc Exp Biol Med. 1953 Jul;83(3):608–611. doi: 10.3181/00379727-83-20434. [DOI] [PubMed] [Google Scholar]
  12. ENGEL F. L. The influence of the endocrine glands on fatty acid and ketone body metabolism. AMA Arch Intern Med. 1957 Jul;100(1):18–33. doi: 10.1001/archinte.1957.00260070032003. [DOI] [PubMed] [Google Scholar]
  13. ENGEL M. G., ENGEL F. L. Fasting ketosis in the adrenalectomized and cortisone-treated rat. Endocrinology. 1954 Nov;55(5):593–600. doi: 10.1210/endo-55-5-593. [DOI] [PubMed] [Google Scholar]
  14. ENGEL M. G., ENGEL F. L. Influence of cortisone on the ketogenic response to oxycel corticotropin. Endocrinology. 1958 Jan;62(1):75–77. doi: 10.1210/endo-62-1-75. [DOI] [PubMed] [Google Scholar]
  15. FREDRICKSON D. S., GORDON R. S., Jr Transport of fatty acids. Physiol Rev. 1958 Oct;38(4):585–630. doi: 10.1152/physrev.1958.38.4.585. [DOI] [PubMed] [Google Scholar]
  16. GORDON R. S., Jr, CHERKES A. Production of unesterified fatty acids from isolated rat adipose tissue incubated in vitro. Proc Soc Exp Biol Med. 1958 Jan;97(1):150–151. doi: 10.3181/00379727-97-23672. [DOI] [PubMed] [Google Scholar]
  17. HAUGAARD E. S., HAUGAARD N. The effect of hyperglycemic-glycogenolytic factor on fat metabolism of liver. J Biol Chem. 1954 Feb;206(2):641–645. [PubMed] [Google Scholar]
  18. HEMING A. E., HOLTKAMP D. E. Calorigenic and antigoitrogenic actions of L-triiodothyronine and L-thyroxine in thyroidectomized and intact rats. Proc Soc Exp Biol Med. 1953 Aug-Sep;83(4):875–879. doi: 10.3181/00379727-83-20520. [DOI] [PubMed] [Google Scholar]
  19. KALANT N. Metabolic effects of the pancreatic hyperglycemic factor. Proc Soc Exp Biol Med. 1954 Jul;86(3):617–619. doi: 10.3181/00379727-86-21180. [DOI] [PubMed] [Google Scholar]
  20. KREBS H. Biochemical aspects of ketosis. Proc R Soc Med. 1960 Feb;53:71–80. doi: 10.1177/003591576005300201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LEVY A. C., RAMEY E. R. The effect of adrenal steroids on peripheral fat mobilization in the rat. Endocrinology. 1959 Apr;64(4):586–591. doi: 10.1210/endo-64-4-586. [DOI] [PubMed] [Google Scholar]
  22. MADISON L. L., COMBES B., ADAMS R., STRICKLAND W. The physiological significance of the secretion of endogenous insulin into the portal circulation. III. Evidence for a direct immediate effect of insulin on the balance of glucose across the liver. J Clin Invest. 1960 Mar;39:507–522. doi: 10.1172/JCI104065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. McCALLA C., GATES H. S., Jr, GORDON R. S., Jr C1402 Excretion after the intravenous administration of albumin-bound palmitate-1-C14 to intact rats. Arch Biochem Biophys. 1957 Oct;71(2):346–351. doi: 10.1016/0003-9861(57)90044-9. [DOI] [PubMed] [Google Scholar]
  24. McPHERSON H. T., WERK E. E., Jr, MYERS J. D., ENGEL F. L. Studies on ketone metabolism in man. II. The effect of glucose, insulin, cortisone and hypoglycemia on splanchnic ketone production. J Clin Invest. 1958 Oct;37(10):1379–1393. doi: 10.1172/JCI103728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. PERRY W. F., BOWEN H. F. In vivo metabolism of fatty acids by adipose and liver tissue of the adrenalectomized rat. Am J Physiol. 1957 Jun;189(3):433–436. doi: 10.1152/ajplegacy.1957.189.3.433. [DOI] [PubMed] [Google Scholar]
  26. PERRY W. F., BOWEN H. F. The in vitro utilization and production of non-esterified fatty acids by adrenalectomized rats. Can J Biochem Physiol. 1961 Jun;39:1061–1065. doi: 10.1139/o61-107. [DOI] [PubMed] [Google Scholar]
  27. RANDLE P. J. The effect of glucagon preparations on the uptake of glucose by isolated rat diaphragm. J Endocrinol. 1958 Nov;17(4):396–400. doi: 10.1677/joe.0.0170396. [DOI] [PubMed] [Google Scholar]
  28. SCOTT J. L., Jr, ENGEL F. L. The influence of the adrenal cortex and cold stress on fasting ketosis in the rat. Endocrinology. 1953 Oct;53(4):410–422. doi: 10.1210/endo-53-4-410. [DOI] [PubMed] [Google Scholar]
  29. SCOW R. O., CHERNICK S. S., GUARCO B. A. Ketogenic action of pituitary and adrenal hormones in pancreatectomized rats. Diabetes. 1959 Mar-Apr;8(2):132–142. doi: 10.2337/diab.8.2.132. [DOI] [PubMed] [Google Scholar]
  30. SOMOGYI M. Exacerbation of diabetes by excess insulin action. Am J Med. 1959 Feb;26(2):169–191. doi: 10.1016/0002-9343(59)90307-9. [DOI] [PubMed] [Google Scholar]
  31. VON EULER U. S., LUFT R. Effect of insulin on urinary excretion of adrenalin and noradrenalin; studies in ten healthy subjects and in six cases of acromegaly. Metabolism. 1952 Nov;1(6):528–532. [PubMed] [Google Scholar]
  32. WERK E. E., Jr, McPHERSON H. T., HAMRICK L. W., Jr, MYERS J. D., ENGEL F. L. Studies on ketone metabolism in man. I. A method for the quantitative estimation of splanchnic ketone production. J Clin Invest. 1955 Aug;34(8):1256–1267. doi: 10.1172/JCI103172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. WERTHEIMER E., SHAFRIR E. Influence of hormones on adipose tissue as a center of fat metabolism. Recent Prog Horm Res. 1960;16:467–495. [PubMed] [Google Scholar]
  34. YALOW R. S., BERSON S. A. Immunoassay of insulin content of crystalline glucagon preparations. Proc Soc Exp Biol Med. 1961 May;107:148–151. doi: 10.3181/00379727-107-26562. [DOI] [PubMed] [Google Scholar]

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