Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1962 Apr;41(4):917–934. doi: 10.1172/JCI104547

PATHOGENESIS OF THE COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (“FIBRINOLYTIC”) STATES. II. THE SIGNIFICANCE, MECHANISM AND CONSEQUENCES OF DEFECTIVE FIBRIN POLYMERIZATION*

Norma Alkjaersig 1, Anthony P Fletcher 1, Sol Sherry 1
PMCID: PMC290992  PMID: 13860492

Full text

PDF

Images in this article

922Image
on p.922
923Image
on p.923
924Image
on p.924
924Image
on p.924
925Image
on p.925
925Image
on p.925
927Image
on p.927
927Image
on p.927

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALKJAERSIG N., FLETCHER A. P., SHERRY S. The mechanism of clot dissolution by plasmin. J Clin Invest. 1959 Jul;38(7):1086–1095. doi: 10.1172/JCI103885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ALKJAERSIG N., FLETCHER A. P., SHERRY S. xi-Aminocaproic acid: an inhibitor of plasminogen activation. J Biol Chem. 1959 Apr;234(4):832–837. [PubMed] [Google Scholar]
  3. BANG N. U., FLETCHER A. P., ALKJAERSIG N., SHERRY S. Pathogenesis of the coagulation defect developing during pathological plasma proteolytic ("fibrinolytic") states. III. Demonstration of abnormal clot structure by electron microscopy. J Clin Invest. 1962 Apr;41:935–948. doi: 10.1172/JCI104548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FLETCHER A. P., ALKJAERSIG N., SHERRY S. Pathogenesis of the coagulation defect developing during pathological plasma proteolytic ("fibrinolytic") states. I. The significance of fibrinogen proteolysis and circulating fibrinogen breakdown products. J Clin Invest. 1962 Apr;41:896–916. doi: 10.1172/JCI104546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FLETCHER A. P., ALKJAERSIG N., SHERRY S. The maintenance of a sustained thrombolytic state in man. I. Induction and effects. J Clin Invest. 1959 Jul;38(7):1096–1110. doi: 10.1172/JCI103886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FLETCHER A. P., SHERRY S., ALKJAERSIG N., SMYRNIOTIS F. E., JICK S. The maintenance of a sustained thrombolytic state in man. II. Clinical observations on patients with myocardial infarction and other thromboembolic disorders. J Clin Invest. 1959 Jul;38(7):1111–1119. doi: 10.1172/JCI103887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JOHNSON A. J., McCARTY W. R. The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J Clin Invest. 1959 Sep;38:1627–1643. doi: 10.1172/JCI103941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. KOPEC M., KOWALSKI E., STACHURSKA J. Studies on paracoagulation. Role of antithrombin VI. Thromb Diath Haemorrh. 1960 Dec 15;5:285–295. [PubMed] [Google Scholar]
  9. NIEWIAROWSKI S., KOWALSKI E. Unnouvel anticoagulant dérivé du fibrinogène. Rev Hematol. 1958 Jul-Sep;13(3):320–328. [PubMed] [Google Scholar]
  10. NIEWIAROWSKI S., LATALLO Z., STACHURSKA J. Apparition d'un inhibiteur de la thromboplastinoformation au cours de la protéolyse du fibrinogène. Rev Hematol. 1959 Apr-Jun;14(2):118–128. [PubMed] [Google Scholar]
  11. NUSSENZWEIG V., SELIGMANN M., GRABAR P. [The degradation products of human fibrinogen by plasmin. II. Immunological study: existence of native anti-fibrinogen antibodies possessing different specificities]. Ann Inst Pasteur (Paris) 1961 Apr;100:490–508. [PubMed] [Google Scholar]
  12. NUSSENZWEIG V., SELIGMANN M., PELMONT J., GRABAR P. [The products of degradation of human fibrinogen by plasmin. I. Separation and physicochemical properties]. Ann Inst Pasteur (Paris) 1961 Mar;100:377–389. [PubMed] [Google Scholar]
  13. SHERRY S., FLETCHER A. P., ALKJAERSIG N. Fibrinolysis and fibrinolytic activity in man. Physiol Rev. 1959 Apr;39(2):343–382. doi: 10.1152/physrev.1959.39.2.343. [DOI] [PubMed] [Google Scholar]
  14. TRIANTAPHYLLOPOULOS D. C. Anticoagulant action of TAMe and AFIF. Am J Physiol. 1961 Apr;200:771–774. doi: 10.1152/ajplegacy.1961.200.4.771. [DOI] [PubMed] [Google Scholar]
  15. TRIANTAPHYLLOPOULOS D. C. Anticoagulant effect of incubated fibrinogen. Can J Biochem Physiol. 1958 Mar;36(3):249–259. [PubMed] [Google Scholar]
  16. TRIANTAPHYLLOPOULOS D. C. Effects of intravenous injections of the anticoagulant fraction of incubated fibrinogen on blood coagulation. Can J Biochem Physiol. 1960 Aug;38:909–918. [PubMed] [Google Scholar]
  17. TRIANTAPHYLLOPOULOS D. C. Nature of the thrombin-inhibiting effect of incubated fibrinogen. Am J Physiol. 1959 Sep;197:575–579. doi: 10.1152/ajplegacy.1959.197.3.575. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES