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. 1962 Aug;41(8):1664–1671. doi: 10.1172/JCI104623

CEREBRAL CIRCULATION AND METABOLISM DURING THIOPENTAL ANESTHESIA AND HYPERVENTILATION IN MAN*

Ellison C Pierce Jr 1,†, Christian J Lambertsen 1, Stanley Deutsch 1, Patricia E Chase 1, Harry W Linde 1, Robert D Dripps 1, Henry L Price 1,‡
PMCID: PMC291083  PMID: 14486452

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALKE B., ELLIS J. P., Jr, WELLS J. G. Adaptive responses to hyperventilation. J Appl Physiol. 1958 Mar;12(2):269–277. doi: 10.1152/jappl.1958.12.2.269. [DOI] [PubMed] [Google Scholar]
  2. BATTEY L. L., HEYMAN A., PATTERSON J. L., Jr Effects of ethyl alcohol on cerebral blood flow and metabolism. J Am Med Assoc. 1953 May 2;152(1):6–10. doi: 10.1001/jama.1953.03690010012002. [DOI] [PubMed] [Google Scholar]
  3. BEAN J. W., ELWELL L. H. Vascular response in mammalian skeletal muscle to d-tubocurarine. Am J Physiol. 1951 Mar;164(3):734–741. doi: 10.1152/ajplegacy.1951.164.3.734. [DOI] [PubMed] [Google Scholar]
  4. BRADLEY A. F., SEVERINGHAUS J. W., STUPFEL M. Accuracy of blood pH and PCO2 determinations. J Appl Physiol. 1956 Sep;9(2):189–196. doi: 10.1152/jappl.1956.9.2.189. [DOI] [PubMed] [Google Scholar]
  5. BRADLEY A. F., SEVERINGHAUS J. W., STUPFEL M. Variations of serum carbonic acid pK with pH and temperature. J Appl Physiol. 1956 Sep;9(2):197–200. doi: 10.1152/jappl.1956.9.2.197. [DOI] [PubMed] [Google Scholar]
  6. BRODIE B. B., MARK L. C. The fate of thiopental in man and a method for its estimation in biological material. J Pharmacol Exp Ther. 1950 Jan;98(1):85–96. [PubMed] [Google Scholar]
  7. CLUTTON-BROCK J. The cerebral effects of overventilation. Br J Anaesth. 1957 Mar;29(3):111–113. doi: 10.1093/bja/29.3.111. [DOI] [PubMed] [Google Scholar]
  8. COLLIER C. R., AFFELDT J. E., FARR A. F. Continuous rapid infrared CO2 analysis; fractional sampling and accuracy in determining alveolar CO2. J Lab Clin Med. 1955 Apr;45(4):526–539. [PubMed] [Google Scholar]
  9. DAVIES P. W., BRONK D. W. Oxygen tension in mammalian brain. Fed Proc. 1957 Sep;16(3):689–692. [PubMed] [Google Scholar]
  10. ELWELL L. H., BEAN J. W. Intestinal blood flow in curarization. Am J Physiol. 1953 Jul;174(1):185–190. doi: 10.1152/ajplegacy.1953.174.1.185. [DOI] [PubMed] [Google Scholar]
  11. FAZEKAS J. F., BESSMAN A. N. Coma mechanisms. Am J Med. 1953 Dec;15(6):804–812. doi: 10.1016/0002-9343(53)90172-7. [DOI] [PubMed] [Google Scholar]
  12. GOTOH F., TAZAKI Y., MEYER J. S. Transport of gases through brain and their extravascular vasomotor action. Exp Neurol. 1961 Jul;4:48–58. doi: 10.1016/0014-4886(61)90077-2. [DOI] [PubMed] [Google Scholar]
  13. Kety S. S., Schmidt C. F. THE EFFECTS OF ACTIVE AND PASSIVE HYPERVENTILATION ON CEREBRAL BLOOD FLOW, CEREBRAL OXYGEN CONSUMPTION, CARDIAC OUTPUT, AND BLOOD PRESSURE OF NORMAL YOUNG MEN. J Clin Invest. 1946 Jan;25(1):107–119. doi: 10.1172/JCI101680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LAMBERTSEN C. J., DOUGH R. H., COOPER D. Y., EMMEL G. L., LOESCHCKE H. H., SCHMIDT C. F. Oxygen toxicity; effects in man of oxygen inhalation at 1 and 3.5 atmospheres upon blood gas transport, cerebral circulation and cerebral metabolism. J Appl Physiol. 1953 Mar;5(9):471–486. doi: 10.1152/jappl.1953.5.9.471. [DOI] [PubMed] [Google Scholar]
  15. LAMBERTSEN C. J., OWEN S. G., WENDEL H., STROUD M. W., LURIE A. A., LOCHNER W., CLARK G. F. Respiratory and cerebral circulatory control during exercise at .21 and 2.0 atmospheres inspired p02. J Appl Physiol. 1959 Nov;14:966–982. doi: 10.1152/jappl.1959.14.6.966. [DOI] [PubMed] [Google Scholar]
  16. LASSEN N. A. Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959 Apr;39(2):183–238. doi: 10.1152/physrev.1959.39.2.183. [DOI] [PubMed] [Google Scholar]
  17. MEYER J. S., GOTOH F. Interaction of cerebral hemodynamics and metabolism. Neurology. 1961 Apr;11(4):46–65. doi: 10.1212/wnl.11.4_part_2.46. [DOI] [PubMed] [Google Scholar]
  18. MOYER J. H., PONTIUS R., MORRIS G., HERSHBERGER R. Effect of morphine and n-allylnormorphine on cerebral hemodynamics and oxygen metabolism. Circulation. 1957 Mar;15(3):379–384. doi: 10.1161/01.cir.15.3.379. [DOI] [PubMed] [Google Scholar]
  19. PRICE H. L. General anesthesia and circulatory homeostasis. Physiol Rev. 1960 Apr;40:187–218. doi: 10.1152/physrev.1960.40.2.187. [DOI] [PubMed] [Google Scholar]
  20. PRICE M. L., PRICE H. L. Effects of general anesthetics on contractile responses of rabbit aortic strips. Anesthesiology. 1962 Jan-Feb;23:16–20. doi: 10.1097/00000542-196201000-00003. [DOI] [PubMed] [Google Scholar]
  21. ROBINSON J. S., GRAY T. C. Observations on the cerebral effects of passive hyperventilation. Br J Anaesth. 1961 Feb;33:62–68. doi: 10.1093/bja/33.2.62. [DOI] [PubMed] [Google Scholar]
  22. SCHIEVE J. F., WILSON W. P. The influence of age, anesthesia and cerebral arteriosclerosis on cerebral vascular activity to CO2. Am J Med. 1953 Aug;15(2):171–174. doi: 10.1016/0002-9343(53)90067-9. [DOI] [PubMed] [Google Scholar]
  23. SEVERINGHAUS J. W. Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood. J Appl Physiol. 1958 May;12(3):485–486. doi: 10.1152/jappl.1958.12.3.485. [DOI] [PubMed] [Google Scholar]
  24. SOKOLOFF L. The action of drugs on the cerebral circulation. Pharmacol Rev. 1959 Mar;11(1):1–85. [PubMed] [Google Scholar]
  25. STEPHEN C. R., FABIAN L. W., BOURGEOIS-GAVARDIN M. Hypoventilation and hyperventilation during anesthesia for thoracic surgery. J Am Med Assoc. 1958 Apr 5;166(14):1678–1684. doi: 10.1001/jama.1958.02990140012003. [DOI] [PubMed] [Google Scholar]
  26. SUGIOKA K., DAVIS D. A. Hyperventilation with oxygen-a possible cause of cerebral hypoxia. Anesthesiology. 1960 Mar-Apr;21:135–143. doi: 10.1097/00000542-196003000-00001. [DOI] [PubMed] [Google Scholar]
  27. Scheinberg P., Stead E. A. THE CEREBRAL BLOOD FLOW IN MALE SUBJECTS AS MEASURED BY THE NITROUS OXIDE TECHNIQUE. NORMAL VALUES FOR BLOOD FLOW, OXYGEN UTILIZATION, GLUCOSE UTILIZATION, AND PERIPHERAL RESISTANCE, WITH OBSERVATIONS ON THE EFFECT OF TILTING AND ANXIETY. J Clin Invest. 1949 Sep;28(5 Pt 2):1163–1171. doi: 10.1172/JCI102150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. WECHSLER R. L., DRIPPS R. D., KETY S. S. Blood flow and oxygen consumption of the human brain during anesthesia produced by thiopental. Anesthesiology. 1951 May;12(3):308–314. doi: 10.1097/00000542-195105000-00006. [DOI] [PubMed] [Google Scholar]

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