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. 1962 Sep;41(9):1805–1815. doi: 10.1172/JCI104638

ACCELERATED TURNOVER OF PHOSPHORIBOSYLPYROPHOSPHATE, A PURINE NUCLEOTIDE PRECURSOR, IN CERTAIN GOUTY SUBJECTS*

Oliver W Jones Jr 1,2,†, Doris M Ashton 1,2, James B Wyngaarden 1,2
PMCID: PMC291102  PMID: 14452314

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENEDICT J. D., FORSHAM P. H., STETTEN D., Jr The metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acid. J Biol Chem. 1949 Nov;181(1):183–193. [PubMed] [Google Scholar]
  2. BENEDICT J. D., ROCHE M., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism. 1952 Jan;1(1):3–12. [PubMed] [Google Scholar]
  3. BENEDICT J. D., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout. J Clin Invest. 1953 Aug;32(8):775–777. doi: 10.1172/JCI102791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GRAYZEL A. I., LIDDLE L., SEEGMILLER J. E. Diagnostic significance of hyperuricemia in arthritis. N Engl J Med. 1961 Oct 19;265:763–768. doi: 10.1056/NEJM196110192651601. [DOI] [PubMed] [Google Scholar]
  5. GUTMAN A. B., YU F. T., ADLER M., JAVITT N. B. Intramolecular distribution of uric acid-N15 after administration of glycine-N15 and ammonium-N15 chloride to goury and non-goury subjects. J Clin Invest. 1962 Mar;41:623–636. doi: 10.1172/JCI104518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GUTMAN A. B., YU T. F., BLACK H., YALOW R. S., BERSON S. A. Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Am J Med. 1958 Dec;25(6):917–932. doi: 10.1016/0002-9343(58)90063-9. [DOI] [PubMed] [Google Scholar]
  7. GUTMAN A. B., YU T. F. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med. 1957 Oct;23(4):600–622. doi: 10.1016/0002-9343(57)90231-0. [DOI] [PubMed] [Google Scholar]
  8. HARTMAN S. C., BUCHANAN J. M. Biosynthesis of the purines. XXI. 5-Phosphoribosylpyrophosphate amidotransferase. J Biol Chem. 1958 Aug;233(2):451–455. [PubMed] [Google Scholar]
  9. HIATT H. H. Studies of ribose metabolism. II. A method for the study of ribose synthesis in vivo. J Biol Chem. 1957 Dec;229(2):725–730. [PubMed] [Google Scholar]
  10. HIATT H. H. Studies of ribose metabolism. VI. Pathways of ribose synthesis in man. J Clin Invest. 1958 Oct;37(10):1461–1464. doi: 10.1172/JCI103737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HJERTEN S., LEVIN O., TISELIUS A. Protein chromatography on calcium phosphate columns. Arch Biochem Biophys. 1956 Nov;65(1):132–155. doi: 10.1016/0003-9861(56)90183-7. [DOI] [PubMed] [Google Scholar]
  12. Hunter G. A new test for ergothioneine upon which is based a method for its estimation in simple solution and in blood-filtrates. Biochem J. 1928;22(1):4–10. doi: 10.1042/bj0220004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. LIEBERMAN I., KORNBERG A., SIMMS E. S. Enzymatic synthesis of pyrimidine nucleotides; orotidine-5'-phosphate and uridine-5'-phosphate. J Biol Chem. 1955 Jul;215(1):403–451. [PubMed] [Google Scholar]
  14. MEHLER A. H., TABOR H., BAUER H. The oxidation of histamine to imidazoleacetic acid in vivo. J Biol Chem. 1952 May;197(1):475–480. [PubMed] [Google Scholar]
  15. PLANTA R. J., GRUBER M. Specificity of cathepsin C. Biochim Biophys Acta. 1961 Oct 28;53:443–444. doi: 10.1016/0006-3002(61)90469-3. [DOI] [PubMed] [Google Scholar]
  16. PREISS J., HANDLER P. Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects. J Biol Chem. 1958 Aug;233(2):493–500. [PubMed] [Google Scholar]
  17. SEEGMILLER J. E., GRAYZEL A. I., LASTER L., LIDDLE L. Uric acid production in gout. J Clin Invest. 1961 Jul;40:1304–1314. doi: 10.1172/JCI104360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SORENSEN L. B. Degradation of uric acid in man. Metabolism. 1959 Sep;8:687–703. [PubMed] [Google Scholar]
  19. Smith L. H., Sullivan M., Huguley C. M. PYRIMIDINE METABOLISM IN MAN. IV. THE ENZYMATIC DEFECT OF OROTIC ACIDURIA. J Clin Invest. 1961 Apr;40(4):656–664. doi: 10.1172/JCI104298. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. TAKAGI Y., HORECKER B. L. Purification and properties of a bacterial riboside hydrolase. J Biol Chem. 1957 Mar;225(1):77–86. [PubMed] [Google Scholar]
  21. WYNGAARDEN J. B. 2, 6-Diaminopurine as substrate and inhibitor of xanthine oxidase. J Biol Chem. 1957 Jan;224(1):453–462. [PubMed] [Google Scholar]
  22. WYNGAARDEN J. B., ASHTON D. M. The regulation of activity of phosphoribosyl-pyrophosphate amidotransferase by purine ribonacleotides: a potential feedback control of purine biosyntoesis. J Biol Chem. 1959 Jun;234(6):1492–1496. [PubMed] [Google Scholar]
  23. WYNGAARDEN J. B., BLAIR A. E., HILLEY L. On the mechanism of overproduction of uric acid in patients with primary gout. J Clin Invest. 1958 Apr;37(4):579–590. doi: 10.1172/JCI103641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. WYNGAARDEN J. B., JONES O. W. The pathogenesis of gout. Med Clin North Am. 1961 Sep;45:1241–1258. doi: 10.1016/s0025-7125(16)33832-9. [DOI] [PubMed] [Google Scholar]
  25. WYNGAARDEN J. B. Normal glycine-C14-incorporation into uric acid in primary gout. Metabolism. 1958 Jul;7(4 Pt 1):374–375. [PubMed] [Google Scholar]
  26. WYNGAARDEN J. B. On the dual etiology of hyperuricemia in primary gout. Arthritis Rheum. 1960 Oct;3:414–420. doi: 10.1002/art.1780030507. [DOI] [PubMed] [Google Scholar]
  27. WYNGAARDEN J. B. Overproduction of uric acid as the cause of hyperuricemia in primary gout. J Clin Invest. 1957 Oct;36(10):1508–1515. doi: 10.1172/JCI103547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. WYNGAARDEN J. B., SEGAL S., FOLEY J. B. Physiological disposition and metabolic fate of infused pentoses in man. J Clin Invest. 1957 Oct;36(10):1395–1407. doi: 10.1172/JCI103539. [DOI] [PMC free article] [PubMed] [Google Scholar]

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