Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1962 Nov;41(11):1988–1997. doi: 10.1172/JCI104657

THE MECHANISM OF ANTIDIURESIS ASSOCIATED WITH THE ADMINISTRATION OF HYDROCHLOROTHIAZIDE TO PATIENTS WITH VASOPRESSIN-RESISTANT DIABETES INSIPIDUS*

Laurence E Earley 1,†, Jack Orloff 1
PMCID: PMC291129  PMID: 16695887

Full text

PDF
1988

Images in this article

1989Image
on p.1989
1992Image
on p.1992
1993Image
on p.1993

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERLINER R. W., DAVIDSON D. G. Production of hypertonic urine in the absence of pituitary antidiuretic hormone. J Clin Invest. 1957 Oct;36(10):1416–1427. doi: 10.1172/JCI103541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOWMAN R. L., TRANTHAM H. V., CAULFIELD P. A. An instrument and method for rapid, dependable determination of freezing point depression. J Lab Clin Med. 1954 Feb;43(2):310–315. [PubMed] [Google Scholar]
  3. CAPPS J. N., WIGGINS W. S., AXELROD D. R., PITTS R. F. The effect of mercurial diuretics on the excretion of water. Circulation. 1952 Jul;6(1):82–89. doi: 10.1161/01.cir.6.1.82. [DOI] [PubMed] [Google Scholar]
  4. COTLOVE E., TRANTHAM H. V., BOWMAN R. L. An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples. J Lab Clin Med. 1958 Mar;51(3):461–468. [PubMed] [Google Scholar]
  5. CRAWFORD J. D., KENNEDY G. C. Chlorothiazid in diabetes insipidus. Nature. 1959 Mar 28;183(4665):891–892. doi: 10.1038/183891a0. [DOI] [PubMed] [Google Scholar]
  6. CRAWFORD J. D., KENNEDY G. C., HILL L. E. Clinical results of treatment of diabetes insipidus with drugs of the chlorothiazide series. N Engl J Med. 1960 Apr 14;262:737–743. doi: 10.1056/NEJM196004142621501. [DOI] [PubMed] [Google Scholar]
  7. EARLEY L. E., KAHN M., ORLOFF J. The effects of infusions of chlorothiazide on urinary dilution and concentration in the dog. J Clin Invest. 1961 May;40:857–866. doi: 10.1172/JCI104320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. EDMONDS C. J., WILSON G. M. The action of hydroflumethiazide in relation to adrenal steroids and potassium loss. Lancet. 1960 Mar 5;1(7123):505–509. doi: 10.1016/s0140-6736(60)90447-5. [DOI] [PubMed] [Google Scholar]
  9. GOLDSTEIN M. H., LEVITT M. F., HAUSER A. D., POLIMEROS D. Effect of meralluride on solute and water excretion in hydrated man: comments on site of action. J Clin Invest. 1961 Apr;40:731–742. doi: 10.1172/JCI104307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HAVARD C. W., WOOD P. H. Antidiuretic properties of hydrochlorothiazide in diabetes insipidus. Br Med J. 1960 Apr 30;1(5182):1306–1308. doi: 10.1136/bmj.1.5182.1306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HAVARD C. W., WOOD P. H. The effect of diuretics on renal water excretion in diabetes insipidus. Clin Sci. 1961 Dec;21:321–332. [PubMed] [Google Scholar]
  12. HEINEMANN H. O., BECKER E. L. Effect of a mercurial diuretic on the excretion of free water in diabetes insipidus. J Appl Physiol. 1958 Jan;12(1):51–54. doi: 10.1152/jappl.1958.12.1.51. [DOI] [PubMed] [Google Scholar]
  13. HEINEMANN H. O., DEMARTINI F. E., LARAGH J. H. The effect of chlorothiazide on renal excretion of electrolytes and free water. Am J Med. 1959 Jun;26(6):853–861. doi: 10.1016/0002-9343(59)90207-4. [DOI] [PubMed] [Google Scholar]
  14. JAENIKE J. R. The influence of vasopressin on the permeability of the mammalian collecting duct to urea. J Clin Invest. 1961 Jan;40:144–151. doi: 10.1172/JCI104228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. KAHN M. Effect of chlorothiazide on electrolyte excretion in intact and adrenalectomized rats. Am J Physiol. 1962 Jun;202:1141–1143. doi: 10.1152/ajplegacy.1962.202.6.1141. [DOI] [PubMed] [Google Scholar]
  16. KENNEDY G. C., CRAWFORD J. D. A comparison of the effects of adrenalectomy and of chlorothiazide in experimental diabetes insipidus. J Endocrinol. 1961 Mar;22:77–86. doi: 10.1677/joe.0.0220077. [DOI] [PubMed] [Google Scholar]
  17. KENNEDY G. C., CRAWFORD J. D. Treatment of diabetes insipidus with hydrochlorothiazide. Lancet. 1959 Apr 25;1(7078):866–867. doi: 10.1016/s0140-6736(59)91943-9. [DOI] [PubMed] [Google Scholar]
  18. LARAGH J. H., HEINEMANN H. O., DEMARTINI F. E. Effect of chlorothiazide on electrolyte transport in man; its use in the treatment of edema of congestive heart failure, nephrosis, and cirrhosis. J Am Med Assoc. 1958 Jan 11;166(2):145–152. doi: 10.1001/jama.1958.02990020033006. [DOI] [PubMed] [Google Scholar]
  19. LINKE A. [Treatment of diabetes insipidus with diuretic sulfonamides]. Med Welt. 1960 Apr 30;18:968–973. [PubMed] [Google Scholar]
  20. LUETSCHER J. A., Jr, AXELRAD B. J. Increased aldosterone output during sodium deprivation in normal men. Proc Soc Exp Biol Med. 1954 Dec;87(3):650–653. doi: 10.3181/00379727-87-21472. [DOI] [PubMed] [Google Scholar]
  21. ORLOFF J., WAGNER H. N., Jr, DAVIDSON D. G. The effect of variations in solute excretion and vasopressin dosage on the excretion of water in the dog. J Clin Invest. 1958 Mar;37(3):458–464. doi: 10.1172/JCI103625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. ROSENBAUM J. D., NELSON W. P., 3rd, STRAUSS M. B., DAVIS R. K., ROSSMEISL E. C. Variation in the diurectic response to ingested water related to the renal excretion of solutes. J Clin Invest. 1953 May;32(5):394–404. doi: 10.1172/JCI102751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. STRAUSS M. B., LAMDIN E., SMITH W. P., BLEIFER D. J. Surfeit and deficit of sodium; a kinetic concept of sodium excretion. AMA Arch Intern Med. 1958 Oct;102(4):527–536. doi: 10.1001/archinte.1958.00260210013003. [DOI] [PubMed] [Google Scholar]
  24. WALSER M., DAVIDSON D. G., ORLOFF J. The renal clearance of alkali-stable inulin. J Clin Invest. 1955 Oct;34(10):1520–1523. doi: 10.1172/JCI103204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. WESSON L. G., Jr, ANSLOW W. P., Jr Effect of osmotic and mercurial diuresis on simultaneous water diuresis. Am J Physiol. 1952 Aug;170(2):255–269. doi: 10.1152/ajplegacy.1952.170.2.255. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES