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. 1976 May;31(5):664–667. doi: 10.1128/aem.31.5.664-667.1976

Teratogenicity of patulin and patulin adducts formed with cysteine.

A Ciegler, A C Beckwith, L K Jackson
PMCID: PMC291173  PMID: 1275488

Abstract

The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mug and that for the 4-day-old embryo was 2.35 mug. Both patulin (1 to 2 mug/egg) and the reaction mixture between patulin and cysteine (15 to 150 mug of patulin equivalents) were teratogenic to the chicken embryo. At least two ninhydrin-negative and four ninhydrin-positive products were formed during the latter reaction. Our explanation of the reaction mechanism remains to be elaborated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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