Figure 6.

Group discrimination using Salience Network and DMN metrics. (A) Scatterplot of Salience Network (SN) scores of healthy controls (HC), patients with bvFTD and Alzheimer’s disease (AD) with respect to clinical diagnosis. Each subject’s Salience Network score represents the average z-score across fourteen regions of interest derived from a Salience Network (bvFTD < healthy control) + (Alzheimer’s disease > healthy control) conjunction analysis (Supplementary Table 3). (B) DMN scores were computed in a parallel fashion, using eight regions of interest derived from a DMN (Alzheimer’s disease < healthy control) + (bvFTD > healthy control) conjunction analysis (Supplementary Table 3). (C) The combined Salience Network minus DMN index provided superior group discrimination compared to analysis of either network alone. Dot columns were converted to clouds by random number assignment within each group to improve scatter visualization. Key for colours and shapes is provided at the bottom.