Abstract
Twenty isolates of Penicillium oxalicum produced secalonic acid as their major secondary metabolite. Fermentation conditions were determined for toxin production in grain and liquid media. The 50% lethal dose value for mice ranged from 26.5 to 51.7 mg/kg dependent on animal strain and sex, males being more susceptible than females. Secalonic acid was nontoxic and nonteratogenic to the chicken embryo and exhibited poor antibiotic properties. Its potential role in mycotoxicoses is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersen R., Büchi G., Kobbe B., Demain A. L. Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus. J Org Chem. 1977 Jan 21;42(2):352–353. doi: 10.1021/jo00422a042. [DOI] [PubMed] [Google Scholar]
- Carlton W. W., Tuite J., Mislivec P. Investigations of the toxic effects in mice of certain species of Penicillium. Toxicol Appl Pharmacol. 1968 Nov;13(3):372–387. doi: 10.1016/0041-008x(68)90113-0. [DOI] [PubMed] [Google Scholar]
- Ciegler A., Vesonder R. F., Jackson L. K. Produciton and biological activity of patulin and citrinin from Penicillium expansum. Appl Environ Microbiol. 1977 Apr;33(4):1004–1006. doi: 10.1128/aem.33.4.1004-1006.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard C. C., Johnstone R. A. Fungal metabolites. 1. Stereochemical features and mass spectrometry secalonic acids. J Chem Soc Perkin 1. 1973;17:2033–2036. [PubMed] [Google Scholar]
- Scott D. B. Toxigenic fungi isolated from cereal and legume products. Mycopathol Mycol Appl. 1965 Apr 14;25(3):213–222. doi: 10.1007/BF02049914. [DOI] [PubMed] [Google Scholar]
- Steyn P. S. The isolation, structure and absolute configuration of secalonic acid D, the toxic metabolite of Penicillium oxalicum. Tetrahedron. 1970 Jan;26(1):51–57. doi: 10.1016/0040-4020(70)85006-2. [DOI] [PubMed] [Google Scholar]
- Wilson B. J., Maronpot R. R. Causative fungus agent of leucoencephalomalacia in equine animals. Vet Rec. 1971 May 8;88(19):484–486. doi: 10.1136/vr.88.19.484. [DOI] [PubMed] [Google Scholar]
- Yamazaki M., Maebayashi Y., Miyaki K. The isolation of secalonic acid A from Aspergillus ochraceus cultured on rice. Chem Pharm Bull (Tokyo) 1971 Jan;19(1):199–201. doi: 10.1248/cpb.19.199. [DOI] [PubMed] [Google Scholar]