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. 1980 Mar;39(3):572–575. doi: 10.1128/aem.39.3.572-575.1980

Impairment of phagocytosis by heterophils from chickens during ochratoxicosis.

C F Chang, P B Hamilton
PMCID: PMC291380  PMID: 7387156

Abstract

The effect of graded concentrations of dietary ochratoxin A (0, O.5, 1.0, 2.0, 4.0, and 8.0 microgram/g of diet) on the in vitro phagocytic, locomotory, and bactericidal capacities of heterophils from broiler chickens was investigated. Both the percentage and the mean phagocytic activities were decreased significantly (P less than 0.05) at 4.0 and 8.0 microgram/g. Both directed and undirected locomotion of heterophila was impaired significantly at the same concentrations. A crossover experiment revealed that the reduced percentage of phagocytosis was associated with the heterophil itself and not with a serum factor such as complement. Heterophila from birds that consumed 4.0 microgram/g were not impaired in ability to kill engulfed bacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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