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. Author manuscript; available in PMC: 2011 Apr 3.
Published in final edited form as: Tetrahedron. 2010 Apr 3;66(14):2582–2588. doi: 10.1016/j.tet.2010.01.093

Scheme 2.

Scheme 2

Reagents and conditions: (a) 1.0 equiv aldehyde, 1.1 equiv α-cyanomethylester, 0.1 equiv piperidine, MeOH, 50 °C, 8h; (b) 8.0 equiv piperidine, benzene/HMPA: 1/1, 0 °C, 8.0 equiv nBuLi, 0 °C, 15 min; then 1.0 equiv aldehyde, 25 °C, 12 h, 35%.