Table 1.
Cmp # | R1 | R2 | E1 | E2 | Yield (%) |
---|---|---|---|---|---|
5a | OMe | H | CN | CO2Me | 84 |
5b | NH2 | H | CN | CO2Me | 87 |
5c | NH2 | H | CN | CN | 65 |
5d | NMe2 | H | CN | CO2Me | 89 |
5e | NMe2 | H | CN | CN | 91 |
5f | NMe2 | H | CN | SO2Ph | 92 |
5g | NMe2 | H | CO2Me | CO2Me | 17 |
5h | NMe2 | OMe | CN | SO2Ph | 81 |
5i | NMe2 | OMe | CN | CO2Me | 89 |
5j | NMe2 | Me | CN | CO2Me | 86 |
5k | NEt2 | H | CN | CO2Me | 67 |
5l | NMe2 | H | SO2Ph | SO2Ph | 7 |
5m | NBu2 | H | CN | CO2Me | 72 |