Table 1:
Overlap between the Genomic Grade Index (GGI) signature [25] and transcripts co- or inversely associated with POLQ in seed-clustering of 1015 breast cancer samples
| Symbol | GGI grades | Accession Number | Gene ID | Full name/description |
|---|---|---|---|---|
| s G1 and G3 are the sets of genes with increased expression in histologic grade 1 and 3 tumors, respectively | ||||
| Transcripts co-expressed with POLQ | ||||
| AURKA | G3 | NM_003158 | 6790 | aurora kinase A |
| CCNB2 | G3 | NM_004701 | 9133 | cyclin B2 |
| CCNB2 | G3 | NM_004701 | 9133 | cyclin B2 |
| CCNE2 | G3 | NM_004702 | 9134 | cyclin E2 |
| CDKN3 | G3 | AF213033 | 1033 | cyclin-dependent kinase inhibitor 3 (CDK2 associated dual specificity phosphatase) |
| CEP55 | G3 | NM_018131 | 55165 | centrosomal protein 55kDa |
| ESPL1 | G3 | NM_012291 | 9700 | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| ESPL1 | G3 | D79987 | 9700 | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| GTSE1 | G3 | NM_016426 | 51512 | G-2 and S-phase expressed 1 |
| KIFC1 | G3 | BC000712 | 3833 | kinesin family member C1 |
| LMNB1 | G3 | NM_005573 | 4001 | lamin B1 |
| MCM2 | G3 | NM_004526 | 4171 | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) |
| MELK | G3 | NM_014791 | 9833 | maternal embryonic leucine zipper kinase |
| MYBL2 | G3 | NM_002466 | 4605 | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 |
| NA | G3 | BE966236 | NA | NA |
| NCAPG | G3 | NM_022346 | 64151 | non-SMC condensin I complex, subunit G |
| POLQ | G3 | NM_006596 | 10721 | polymerase (DNA directed), theta |
| PRC1 | G3 | NM_003981 | 9055 | protein regulator of cytokinesis 1 |
| RRM2 | G3 | BC001886 | 6241 | ribonucleotide reductase M2 polypeptide |
| TIMELESS | G3 | NM_003920 | 8914 | timeless homolog (Drosophila) |
| TRIP13 | G3 | NM_004237 | 9319 | thyroid hormone receptor interactor 13 |
| Transcripts whose expression is inversely associated with POLQ expression | ||||
| CX3CR | G1 | U20350 | 1524 | chemokine (C-X3-C motif) receptor 1 |