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. 1971 May;50(5):1108–1115. doi: 10.1172/JCI106582

NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia

Parviz Lalezari 1,2, Georgette B Murphy 1,2, Fred H Allen Jr 1,2
PMCID: PMC292033  PMID: 5552408

Abstract

A new human antigen is reported which is present only on blood neutrophils. A neutrophil-specific antigen, designated NA1, has previously been identified in two unrelated families, and was shown to be involved in fetomaternal incompatibility and the development of isoimmune neonatal neutropenia in five newborns. In the present paper, a second antigen, designated NB1, is identified in four families with seven affected children. Antibodies that react with this second antigen are shown to produce selective agglutination of neutrophils but not other blood cells. They are neither absorbed by cells prepared from solid tissues nor by non-neutrophilic blood cells.

By family and population studies, NB is shown to be distinct from NA, representing an independent genetic locus. 68% of the New York population are homozygous for NB1, 29% heterozygous, and 3% negative. The NB locus is shown to be independent from those of HL-A and other known leukocyte antigens. No evidence for linkage between NA, NB, and red cell antigens was obtained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUCKWOLD A. E., EMSON H. E. Acute neonatal neutropenia in siblings. Can Med Assoc J. 1959 Jan 15;80(2):116–119. [PMC free article] [PubMed] [Google Scholar]
  2. Kekwick R. A. The serum proteins in multiple myelomatosis. Biochem J. 1940 Sep;34(8-9):1248–1257. doi: 10.1042/bj0341248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. LALEZARI P., BERNARD G. E. IDENTIFICATION OF A SPECIFIC LEUKOCYTE ANTIGEN: ANOTHER PRESUMED EXAMPLE OF 5B. Transfusion. 1965 Mar-Apr;5:135–142. doi: 10.1111/j.1537-2995.1965.tb01148.x. [DOI] [PubMed] [Google Scholar]
  4. LALEZARI P., NUSSBAUM M., GELMAN S., SPAET T. H. Neonatal neutropenia due to maternal isoimmunization. Blood. 1960 Feb;15:236–243. [PubMed] [Google Scholar]
  5. LEHNDORFF H. Transitorische Granulocytopenie beim Neugeborenen. Helv Paediatr Acta. 1951 Jun;6(3):173–183. [PubMed] [Google Scholar]
  6. Lalezari P., Bernard G. E. An isologous antigen-antibody reaction with human neutrophiles, related to neonatal neutropenia. J Clin Invest. 1966 Nov;45(11):1741–1750. doi: 10.1172/JCI105480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  8. ROSSI J. P., BRANDT I. K. Transient granulocytopenia of the newborn associated with sepsis due to Shigella alkalescens and maternal leukocyte agglutinins: a case report. J Pediatr. 1960 May;56:639–647. doi: 10.1016/s0022-3476(60)80338-1. [DOI] [PubMed] [Google Scholar]
  9. SLOBODY L. B., ABRAMSON H., LOIZEAUX L. S., Jr Agranulocytosis of the newborn infant. J Am Med Assoc. 1950 Jan 7;142(1):25–25. doi: 10.1001/jama.1950.72910190001006. [DOI] [PubMed] [Google Scholar]

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