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. 1971 Jun;50(6):1329–1337. doi: 10.1172/JCI106612

The distribution of sodium-potassium-activated adenosine triphosphatase in medulla and cortex of the kidney

Ernesto D Hendler 1, Jorge Torretti 1, Franklin H Epstein 1
PMCID: PMC292064  PMID: 4325313

Abstract

The activity of sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is considerably higher in homogenates of outer medulla than in the cortex or papilla of the kidney. The enzyme has similar kinetic characteristics in both cortex and medulla, and binds ouabain in the same proportion. The discrepancy in enzymatic activity is not paralleled by similar change in the activity of adenyl cyclase, 5′nucleotidase, glucose-6-phosphatase, or succinic dehydrogenase. Na-K-ATPase is also higher in distal convoluted tubules (ventral slices) than in the proximal tubules (dorsal slices) of the kidney of Amphiuma. The high concentration of Na-K-ATPase in the red medulla of the kidney is probably related to the presence here of the thick ascending limb of the loop of Henle, and this has important implications with regard to the mechanism of sodium reabsorption by different portions of the nephron.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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