Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1971 Jul;50(7):1429–1438. doi: 10.1172/JCI106626

Effect of renal vasodilatation on the distribution of cortical blood flow in the kidney of the dog

Jay H Stein 1, Thomas F Ferris 1, James E Huprich 1, Timothy C Smith 1, Richard W Osgood 1
PMCID: PMC292081  PMID: 5090058

Abstract

Studies were performed to evaluate the validity of using the radioactive microsphere technique to measure regional blood flow in the renal cortex. A technique was developed in which the renal cortex was divided into four equal zones, and the fractional and absolute distribution of blood flow in these zones was determined. It was consistently found that approximately 70% of the renal blood flow was distributed to the two outer cortical zones with the remaining 30% going to the two inner cortical zones. In addition, there was a reproducible pattern of distribution of blood flow in different areas of the same kidney after a single injection of microspheres and in the same area of the kidney after multiple injections of microspheres.

Using this method, the distribution of renal blood flow was determined before and during the intrarenal administration of either acetylcholine (40 μg/min) or bradykinin (5 μg/min). Both agents decreased the per cent of blood flow to outer cortical zone 1, caused no change in zone 2, and increased the fractional blood flow in inner cortical zones 3 and 4. When this data was evaluated in terms of total blood flow, there was no change in zone 1, an increase in zone 2 commensurate with the change in total blood flow, and a marked increase in inner cortical zones 3 and 4 which accounted for 60 and 65% of the increase in total blood flow during acetylcholine and bradykinin administration, respectively.

Therefore, the natriuresis of renal vasodilatation is associated with a redistribution to inner cortical nephrons.

Full text

PDF
1429

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aukland K., Wolgast M. Effect of hemorrhage and retransfusion on intrarenal distribution of blood flow in dogs. J Clin Invest. 1968 Mar;47(3):488–501. doi: 10.1172/JCI105745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baines A. D., Baines C. J., de Rouffignac C. Functional heterogeneity of nephrons. I. Intraluminal flow velocities. Pflugers Arch. 1969;308(3):244–259. doi: 10.1007/BF00586557. [DOI] [PubMed] [Google Scholar]
  3. Barger A. C. Renal hemodynamic factors in congestive heart failure. Ann N Y Acad Sci. 1966 Nov 22;139(2):276–284. doi: 10.1111/j.1749-6632.1966.tb41202.x. [DOI] [PubMed] [Google Scholar]
  4. EARLEY L. E., FRIEDLER R. M. CHANGES IN RENAL BLOOD FLOW AND POSSIBLY THE INTRARENAL DISTRIBUTION OF BLOOD DURING THE NATRIURESIS ACCOMPANYING SALINE LOADING IN THE DOG. J Clin Invest. 1965 Jun;44:929–941. doi: 10.1172/JCI105210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Earley L. E., Friedler R. M. The effects of combined renal vasodilatation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium. J Clin Invest. 1966 Apr;45(4):542–551. doi: 10.1172/JCI105368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harvey R. B. Effects of acetylcholine infused into renal artery of dogs. Am J Physiol. 1966 Aug;211(2):487–492. doi: 10.1152/ajplegacy.1966.211.2.487. [DOI] [PubMed] [Google Scholar]
  7. Kaihara S., Rutherford R. B., Schwentker E. P., Wagner H. N., Jr Distribution of cardiac output in experimental hemorrhagic shock in dogs. J Appl Physiol. 1969 Aug;27(2):218–222. doi: 10.1152/jappl.1969.27.2.218. [DOI] [PubMed] [Google Scholar]
  8. McKenna O. C., Angelakos E. T. Adrenergic innervation of the canine kidney. Circ Res. 1968 Mar;22(3):345–354. doi: 10.1161/01.res.22.3.345. [DOI] [PubMed] [Google Scholar]
  9. McNay J. L., Abe Y. Pressure-dependent heterogeneity of renal cortical blood flow in dogs. Circ Res. 1970 Oct;27(4):571–587. doi: 10.1161/01.res.27.4.571. [DOI] [PubMed] [Google Scholar]
  10. Moffat D. B. The fine structure of the blood vessels of the renal medulla with particular reference to the control of the medullary circulation. J Ultrastruct Res. 1967 Aug 30;19(5):532–545. doi: 10.1016/s0022-5320(67)80079-0. [DOI] [PubMed] [Google Scholar]
  11. Neutze J. M., Wyler F., Rudolph A. M. Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Am J Physiol. 1968 Aug;215(2):486–495. doi: 10.1152/ajplegacy.1968.215.2.486. [DOI] [PubMed] [Google Scholar]
  12. PAPPENHEIMER J. R., KINTER W. B. Hematocrit ratio of blood within mammalian kidney and its significance for renal hemodynamics. Am J Physiol. 1956 May;185(2):377–390. doi: 10.1152/ajplegacy.1956.185.2.377. [DOI] [PubMed] [Google Scholar]
  13. PEART W. S. Renin and hypertensin. Ergeb Physiol. 1959;50:409–432. [PubMed] [Google Scholar]
  14. PILKINGTON L. A., BINDER R., DEHAAS J. C., PITTS R. F. INTRARENAL DISTRIBUTION OF BLOOD FLOW. Am J Physiol. 1965 Jun;208:1107–1113. doi: 10.1152/ajplegacy.1965.208.6.1107. [DOI] [PubMed] [Google Scholar]
  15. Rudolph A. M., Heymann M. A. The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res. 1967 Aug;21(2):163–184. doi: 10.1161/01.res.21.2.163. [DOI] [PubMed] [Google Scholar]
  16. Schnermann J., Wright F. S., Davis J. M., von Stackelberg W., Grill G. Regulation of superficial nephron filtration rate by tubulo-glomerular feedback. Pflugers Arch. 1970;318(2):147–175. doi: 10.1007/BF00586493. [DOI] [PubMed] [Google Scholar]
  17. Tagawa H., Vander A. J. Effect of acetylcholine on renin secretion in salt-depleted dogs. Proc Soc Exp Biol Med. 1969 Dec;132(3):1087–1090. doi: 10.3181/00379727-132-34372. [DOI] [PubMed] [Google Scholar]
  18. Thurau K. Influence of sodium concentration at macula densa cells on tubular sodium load. Ann N Y Acad Sci. 1966 Nov 22;139(2):388–399. doi: 10.1111/j.1749-6632.1966.tb41212.x. [DOI] [PubMed] [Google Scholar]
  19. WALSER M., DAVIDSON D. G., ORLOFF J. The renal clearance of alkali-stable inulin. J Clin Invest. 1955 Oct;34(10):1520–1523. doi: 10.1172/JCI103204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wagner H. N., Jr, Rhodes B. A., Sasaki Y., Ryan J. P. Studies of the circulation with radioactive microspheres. Invest Radiol. 1969 Nov-Dec;4(6):374–386. doi: 10.1097/00004424-196911000-00004. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES