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. 1971 Jul;50(7):1551–1553. doi: 10.1172/JCI106641

Dose-Response relationship of luteinizing hormone to luteinizing hormone—releasing hormone in man

Abba J Kastin 1,2,3,4, Andrew V Schally 1,2,3,4, Carlos Gual 1,2,3,4, A Rees Midgley Jr 1,2,3,4, M Clinton Miller III 1,2,3,4, Angela Cabeza 1,2,3,4
PMCID: PMC292096  PMID: 4932985

Abstract

In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 μg resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The present study determined the minimum effective dose as well as the relationship of the response of serum LH and FSH to the dose of LH-RH administered. Three normal men received i.v. injections of 1.1-810 μg of LH-RH. A dose of 10 μg of LH-RH caused a statistically significant elevation in serum LH. 30 μg of LH-RH significantly increased serum FSH levels. A highly significant linear trend was observed in the log dose-response curve. The results indicate that both LH and FSH release occurs in man with doses of LH-RH much lower than previously used and that a linear log dose-response relationship can be obtained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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