Sir,
I read the report by Patted et al. on cardiac Candida krusei infection presenting as a right ventricular mass with great interest.[1] Patted et al. have mentioned that necrotizing enterocolitis and disseminated fungal infection result in an adverse outcome as was seen in their case.[1] Indeed, Candida krusei infection is difficult to treat. Majority of the reported cases with hematogenous spread have died[2] Basic antifungal treatment such as Amphotericin B administration is usually unsuccessful.[3] In the case of cardiac infection, cardiac ischemia leading to death has also been reported.[2] Intravenous Caspofungin therapy has been reported to be the only successful treatment for this condition.[4]
REFERENCES
- 1.Patted SV, Halkati PC, Yavagal ST, Patil R. Candida krusei infection presenting as a right ventricular mass in a two month old Infant. Ann Pediatr Card. 2009;2:170–2. doi: 10.4103/0974-2069.58324. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Safdar A, Bannister TW, Safdar Z. The predictors of outcome in immunocompetent patients with hematogenous candidiasis. Int J Infect Dis. 2004;8:180–6. doi: 10.1016/j.ijid.2003.05.003. [DOI] [PubMed] [Google Scholar]
- 3.Petrocheilou-Paschou V, Georgilis K, Kontoyannis D, Nanas J, Prifti H, Costopoulos H, et al. Pneumonia due to Candida krusei. Clin Microbiol Infect. 2002;8:806–9. doi: 10.1046/j.1469-0691.2002.00488.x. [DOI] [PubMed] [Google Scholar]
- 4.Rajendram R, Alp NJ, Mitchell AR, Bowler IC, Forfar JC. Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement. Clin Infect Dis. 2005;40:e72–4. doi: 10.1086/429322. [DOI] [PubMed] [Google Scholar]
