Fig. 5.
The role of reactive oxygen species (ROS) in the responses of PBEF and IL-8 to stretching was shown by the specific blocking of ROS by NAC (30μM). In AEC the localization of stress fibers (white arrows) and filapodia (green arrows) in primary AEC during 4 h of static stretching. In WISH cells (n=6) static and cyclic stretch/release increased both PBEF (B) and IL-8 (C) gene expression. Values are mean +/-SEM.