Abstract
The present study was carried out to determine if antidiuretic hormone (ADH) altered the solute handling characteristics of the peritoneal membrane. Lightly anesthetized dogs primed with urea-14C (60 mol wt) and inulin (5200 mol wt) were volume expanded with hypotonic saline solution to suppress endogenous ADH as assessed by urine/plasma osmolality. With ADH suppressed, two to three control peritoneal dialysis exchanges were carried out. A constant infusion of ADH in a physiologic dose of 150 mU/hr in saline was begun and the urine/plasma osmolality followed until it was significantly greater than one. Two to three experimental dialysis exchanges were then carried out. Dialysance across the peritoneal membrane was calculated for inulin (DI) and urea (DU). In 16 such studies DU fell in all but three (the mean value for the fall was 2.8 ±2.6 ml/min; P < 0.001). DI varied randomly and showed no significant change. In all 16 studies DI/DU rose (DI/DU = 0.054 ± 0.054; P < 0.005). Seven dogs were studied with an identical protocol but saline was infused without ADH. DU and the dialysance ratio varied randomly. DU fell in one and did not change or rose in four and DI/DU rose in two and fell in three. The data are interpreted to show a fall in area but an increase in mean pore radius of the “peritoneal membrane” in response to physiologic amounts of intravenous ADH. The fall in area is consistent with a decreasing splanchnic blood flow.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HARE H. G., VALTIN H., GOSSELIN R. E. EFFECT OF DRUGS ON PERITONEAL DIALYSIS IN THE DOG. J Pharmacol Exp Ther. 1964 Jul;145:122–129. [PubMed] [Google Scholar]
- HEIMBURGER I., TERAMOTO S., SHUMACKER H. B., Jr Effect of surgical pituitrin upon portal and hepatic circulation. Surgery. 1960 Oct;48:706–715. [PubMed] [Google Scholar]
- Henderson L. W., Nolph K. D. Altered permeability of the peritoneal membrane after using hypertonic peritoneal dialysis fluid. J Clin Invest. 1969 Jun;48(6):992–1001. doi: 10.1172/JCI106080. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson L. W. Peritoneal ultrafiltration dialysis: enhanced urea transfer using hypertonic peritoneal dialysis fluid. J Clin Invest. 1966 Jun;45(6):950–955. doi: 10.1172/JCI105410. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MAETZ J., BOURGUET J., LAHLOUGH B., HOURDRY J. PEPTIDES NEUROHYPOPHYSAIRES ET OSMOREGULATION CHEZ CARASSIUS AURATUS. Gen Comp Endocrinol. 1964 Oct;4:508–522. doi: 10.1016/0016-6480(64)90060-7. [DOI] [PubMed] [Google Scholar]
- Nagel W., Kuschinsky W. Study of the permeability of the isolated dog mesentery. Eur J Clin Invest. 1970 Nov;1(3):149–154. doi: 10.1111/j.1365-2362.1970.tb00610.x. [DOI] [PubMed] [Google Scholar]
- Sawyer W. H. Diuretic and natriuretic responses of lungfish (Protopterus aethiopicus) to arginine vasotocin. Am J Physiol. 1966 Jan;210(1):191–197. doi: 10.1152/ajplegacy.1966.210.1.191. [DOI] [PubMed] [Google Scholar]
- Shear L., Castellot J. J., Shinaberger J. H., Poole L., Barry K. G. Enhancement of peritoneal fluid absorption by dehydration, mercaptomerin and vasopressin. J Pharmacol Exp Ther. 1966 Nov;154(2):289–297. [PubMed] [Google Scholar]
- Shear L., Harvey J. D., Barry K. G. Peritoneal sodium transport: enhancement by pharmacologic and physical agents. J Lab Clin Med. 1966 Feb;67(2):181–188. [PubMed] [Google Scholar]
- TEXTER E. C., Jr Small intestinal blood flow. Am J Dig Dis. 1963 Jul;8:587–613. doi: 10.1007/BF02239457. [DOI] [PubMed] [Google Scholar]
- WALSER M., DAVIDSON D. G., ORLOFF J. The renal clearance of alkali-stable inulin. J Clin Invest. 1955 Oct;34(10):1520–1523. doi: 10.1172/JCI103204. [DOI] [PMC free article] [PubMed] [Google Scholar]