Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1972 Jul;51(7):1927–1931. doi: 10.1172/JCI106998

Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier

Harvey R Colten 1,2,3,4, Kenneth H Gabbay 1,2,3,4
PMCID: PMC292344  PMID: 4113392

Abstract

Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochalasin-sensitive barrier (CSB). This CSB modulation of histamine release can be separated from the modulating effect of cyclic adenosine monophosphate (AMP).

Full text

PDF
1927

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carter S. B. Effects of cytochalasins on mammalian cells. Nature. 1967 Jan 21;213(5073):261–264. doi: 10.1038/213261a0. [DOI] [PubMed] [Google Scholar]
  2. Kooman W. J., Orange R. P., Austen K. F. Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate. J Immunol. 1970 Nov;105(5):1096–1102. [PubMed] [Google Scholar]
  3. LICHTENSTEIN L. M., OSLER A. G. STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN. J Exp Med. 1964 Oct 1;120:507–530. doi: 10.1084/jem.120.4.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Levy D. A., Lichtenstein L. M., Goldstein E. O., Ishizaka K. Immunologic and cellular changes accompanying the therapy of pollen allergy. J Clin Invest. 1971 Feb;50(2):360–369. doi: 10.1172/JCI106503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lichtenstein L. M., DeBernardo R. The immediate allergic response: in vitro action of cyclic AMP-active and other drugs on the two stages of histamine release. J Immunol. 1971 Oct;107(4):1131–1136. [PubMed] [Google Scholar]
  6. Lichtenstein L. M. The immediate allergic response: in vitro separation of antigen activation, decay and histamine release. J Immunol. 1971 Oct;107(4):1122–1130. [PubMed] [Google Scholar]
  7. McGuire J., Moellmann G. Cytochalasin B: effects on microfilaments and movement of melanin granules within melanocytes. Science. 1972 Feb 11;175(4022):642–644. doi: 10.1126/science.175.4022.642. [DOI] [PubMed] [Google Scholar]
  8. Orci L., Gabbay K. H., Malaisse W. J. Pancreatic beta-cell web: its possible role in insulin secretion. Science. 1972 Mar 10;175(4026):1128–1130. doi: 10.1126/science.175.4026.1128. [DOI] [PubMed] [Google Scholar]
  9. Orr T. S., Hall D. E., Allison A. C. Role of contractile microfilaments in the release of histamine from mast cells. Nature. 1972 Apr 14;236(5346):350–351. doi: 10.1038/236350a0. [DOI] [PubMed] [Google Scholar]
  10. Patterson R., Head L. R., Suszko I. M., Zeiss C. R., Jr Mast cells from human respiratory tissue and their in vitro reactivity. Science. 1972 Mar 3;175(4025):1012–1014. doi: 10.1126/science.175.4025.1012. [DOI] [PubMed] [Google Scholar]
  11. SHORE P. A., BURKHALTER A., COHN V. H., Jr A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959 Nov;127:182–186. [PubMed] [Google Scholar]
  12. Schofield J. G. Cytochalasin B and release of growth hormone. Nat New Biol. 1971 Sep 15;234(50):215–216. doi: 10.1038/newbio234215a0. [DOI] [PubMed] [Google Scholar]
  13. Wessells N. K., Spooner B. S., Ash J. F., Bradley M. O., Luduena M. A., Taylor E. L., Wrenn J. T., Yamada K. Microfilaments in cellular and developmental processes. Science. 1971 Jan 15;171(3967):135–143. doi: 10.1126/science.171.3967.135. [DOI] [PubMed] [Google Scholar]
  14. Williams J. A., Wolff J. Cytochalasin B inhibits thyroid secretion. Biochem Biophys Res Commun. 1971 Jul 16;44(2):422–425. doi: 10.1016/0006-291x(71)90617-6. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES