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. 1972 Sep;51(9):2420–2428. doi: 10.1172/JCI107055

HL-A antigens and disease

Acute lymphocytic leukemia

G Nicholas Rogentine Jr 1,2,3,4, R A Yankee 1,2,3,4, J J Gart 1,2,3,4, J Nam 1,2,3,4, R J Trapani 1,2,3,4
PMCID: PMC292410  PMID: 4508824

Abstract

50 Caucasian children with acute lymphocytic leukemia (ALL) and 219 members of their families have been genotyped for 15 antigens of the HL-A system. The antigen and gene frequencies for HL-A2 were significantly higher in the patient population than in a 200 member normal Caucasian panel. No other antigen frequencies were significantly elevated. All antigens typed for were found in the patients. No antigen gain or loss was detected in the leukemic cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. LILLY F., BOYSE E. A., OLD L. J. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS. Lancet. 1964 Dec 5;2(7371):1207–1209. doi: 10.1016/s0140-6736(64)91043-8. [DOI] [PubMed] [Google Scholar]
  2. Lawler S. D., Klouda P. T., Hardisty R. M., Till M. M. Histocompatibility and acute lymphoblastic leukaemia. Lancet. 1971 Apr 3;1(7701):699–699. doi: 10.1016/s0140-6736(71)92704-8. [DOI] [PubMed] [Google Scholar]
  3. Mann D. L., Nathenson S. G. Comparison of soluble human and mouse transplantation antigens. Proc Natl Acad Sci U S A. 1969 Dec;64(4):1380–1387. doi: 10.1073/pnas.64.4.1380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. McDevitt H. O., Bodmer W. F. Protein clinical manifestations of primary tumors of the heart. Am J Med. 1972 Jan;52(1):1–8. doi: 10.1016/0002-9343(72)90002-2. [DOI] [PubMed] [Google Scholar]
  5. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  6. Pegrum G. D., Balfour I. C., Evans C. A., Middleton V. L. HL-A antigens on leukaemic cells. Br J Haematol. 1970 Oct;19(4):493–498. doi: 10.1111/j.1365-2141.1970.tb06977.x. [DOI] [PubMed] [Google Scholar]
  7. Recent progress in human transplantation immunology. Ann Intern Med. 1969 Dec;71(6):1177–1196. doi: 10.7326/0003-4819-71-6-1177. [DOI] [PubMed] [Google Scholar]
  8. Snell G. D. The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol (Praha) 1968;14(5):335–358. [PubMed] [Google Scholar]
  9. TENNANT J. R. SUSCEPTIBILITY AND RESISTANCE TO VIRAL LEUKEMOGENESIS IN THE MOUSE. II. RESPONSE TO THE VIRUS RELATIVE TO HSITOCOMPATIBILITY FACTORS CARRIED BY THE PROSPECTIVE HOST. J Natl Cancer Inst. 1965 May;34:633–641. [PubMed] [Google Scholar]
  10. Thorsby E., Bratlie A., Lie S. O. HL-A genotypes of children with acute leukaemia. A family study. Scand J Haematol. 1969;6(6):409–415. doi: 10.1111/j.1600-0609.1969.tb01835.x. [DOI] [PubMed] [Google Scholar]
  11. WOOLF B. On estimating the relation between blood group and disease. Ann Hum Genet. 1955 Jun;19(4):251–253. doi: 10.1111/j.1469-1809.1955.tb01348.x. [DOI] [PubMed] [Google Scholar]
  12. Walford R. L., Finkelstein S., Neerhout R., Konrad P., Shanbrom E. Acute childhood leukaemia in relation to the HL-A human transplantation genes. Nature. 1970 Jan 31;225(5231):461–462. doi: 10.1038/225461a0. [DOI] [PubMed] [Google Scholar]

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