Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1972 Nov;51(11):2790–2795. doi: 10.1172/JCI107101

Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

Roland C Blantz 1, John D Wallin 1, Floyd C Rector Jr 1, Donald W Seldin 1
PMCID: PMC292427  PMID: 5080409

Abstract

The effect of dietary variation in sodium chloride intake on the intrarenal distribution of plasma flow was investigated in rats using the antiglomerular basement membrane antibody technique. Rats were placed on a liquid diet containing either 9.86 (n = 9) or 0 (n = 9) mEq NaCl/daily portion for 2 wk. Labeled antibody was injected and the diets were reversed. After an additional 2 wk period, antibody labeled with a different radionuclide was injected and the animals were sacrificed. Fractional plasma flow distribution was then calculated for each dietary period. No change in flow to any cortical region could be detected. In six additional awake rats on identical dietary regimen, total plasma flow was estimated by the clearance of hippuran-131I. No change in this parameter occurred with changes in NaCl intake. We conclude, therefore, that no change in either total renal plasma flow or intracortical distribution of plasma flow occurs with wide variations in dietary sodium chloride intake in the rat. The implications of this constancy of regional plasma flow are discussed with reference to presumed concomitant alterations in the intrarenal distribution of nephron filtration rate.

Full text

PDF
2790

Images in this article

2793Image
on p.2793

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartoli E., Earley L. E. Effects of saline infusion on glomerulotubular balance. Kidney Int. 1972 Feb;1(2):67–77. doi: 10.1038/ki.1972.10. [DOI] [PubMed] [Google Scholar]
  2. Blantz R. C., Katz M. A., Rector F. C., Jr, Seldin D. W. Measurement of intrarenal blood flow. II. Effect of saline diuresis in the dog. Am J Physiol. 1971 Jun;220(6):1914–1920. doi: 10.1152/ajplegacy.1971.220.6.1914. [DOI] [PubMed] [Google Scholar]
  3. Blaufox M. D., Fromowitz A., Lee H. B., Mend C. H., Elkin M. Renal blood flow and renin activity in renal venous blood in essential hypertension. Circ Res. 1970 Dec;27(6):913–920. doi: 10.1161/01.res.27.6.913. [DOI] [PubMed] [Google Scholar]
  4. GOODYER A. V., JAEGER C. A. Renal response to nonshocking hemorrhage; role of the autonomic nervous system and of the renal circulation. Am J Physiol. 1955 Jan;180(1):69–74. doi: 10.1152/ajplegacy.1954.180.1.69. [DOI] [PubMed] [Google Scholar]
  5. Gertz K. H., Brandis M., Braun-Schubert G., Boylan J. W. The effect of saline infusion and hemorrhage on glomerular filtration pressure and single nephron filtration rate. Pflugers Arch. 1969;310(3):193–205. doi: 10.1007/BF00587209. [DOI] [PubMed] [Google Scholar]
  6. Hollenberg N. K., Epstein M., Guttmann R. D., Conroy M., Basch R. I., Merrill J. P. Effect of sodium balance on intrarenal distribution of blood flow in normal man. J Appl Physiol. 1970 Mar;28(3):312–317. doi: 10.1152/jappl.1970.28.3.312. [DOI] [PubMed] [Google Scholar]
  7. Horster M., Thurau K. Micropuncture studies on the filtration rate of single superficial and juxtamedullary glomeruli in the rat kidney. Pflugers Arch Gesamte Physiol Menschen Tiere. 1968;301(2):162–181. doi: 10.1007/BF00362733. [DOI] [PubMed] [Google Scholar]
  8. KLEINMAN L. I., RADFORD E. P., Jr, TORELLI G. UREA AND INULIN CLEARANCES IN UNDISTURBED, UNANESTHETIZED RATS. Am J Physiol. 1965 Mar;208:578–584. doi: 10.1152/ajplegacy.1965.208.3.578. [DOI] [PubMed] [Google Scholar]
  9. Katz M. A., Blantz R. C., Rector F. C., Jr, Seldin D. W. Measurement of intrarenal blood flow. I. Analysis of microsphere method. Am J Physiol. 1971 Jun;220(6):1903–1913. doi: 10.1152/ajplegacy.1971.220.6.1903. [DOI] [PubMed] [Google Scholar]
  10. Krieger E. M. Time course of baroreceptor resetting in acute hypertension. Am J Physiol. 1970 Feb;218(2):486–490. doi: 10.1152/ajplegacy.1970.218.2.486. [DOI] [PubMed] [Google Scholar]
  11. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  12. Mandin H., Israelit A. H., Rector F. C., Jr, Seldin D. W. Effect of saline infusions on intrarenal distribution of glomerular filtrate and proximal reabsorption in the dog. J Clin Invest. 1971 Mar;50(3):514–522. doi: 10.1172/JCI106520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wallin J. D., Blantz R. C., Katz M. A., Andreucci V. E., Rector F. C., Jr, Seldin D. W. Effect of saline diuresis on intrarenal blood flow in the rat. Am J Physiol. 1971 Nov;221(5):1297–1304. doi: 10.1152/ajplegacy.1971.221.5.1297. [DOI] [PubMed] [Google Scholar]
  14. Wallin J. D., Rector F. C., Jr, Seldin D. W. Effect of volume expansion on intrarenal distribution of plasma flow in the dog. Am J Physiol. 1972 Jul;223(1):125–129. doi: 10.1152/ajplegacy.1972.223.1.125. [DOI] [PubMed] [Google Scholar]
  15. Wallin J. D., Rector F. C., Jr, Seldin D. W. Measurement of intrarenal plasma flow with antiglomerular basement-membrane antibody. Am J Physiol. 1971 Dec;221(6):1621–1628. doi: 10.1152/ajplegacy.1971.221.6.1621. [DOI] [PubMed] [Google Scholar]
  16. de Rouffignac C., Bonvalet J. P. Etude chez le rat des variations du débit individuel de filtration glomérulaire des néphrons superficiels et profonds en fonction de l'approt sodé. Pflugers Arch. 1970;317(2):141–156. doi: 10.1007/BF00592498. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES