Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1965 Feb;44(2):169–181. doi: 10.1172/JCI105132

Experimental Metabolic Acidosis: The Enzymatic Basis of Ammonia Production by the Dog Kidney*

Victor E Pollak 1,2,3,4,†, Hermann Mattenheimer 1,2,3,4,‡, Hendrina DeBruin 1,2,3,4, Karla J Weinman 1,2,3,4
PMCID: PMC292466  PMID: 14260159

Full text

PDF
169

Images in this article

175Image
on p.175

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BONTING S. L., CARAVAGGIO L. L., CANADY M. R., HAWKINS N. M. STUDIES ON SODIUM-POTASSIUM-ACTIVATED ADENOSINETRIPHOSPHATASE. XI. THE SALT GLAND OF THE HERRING GULL. Arch Biochem Biophys. 1964 Jul 20;106:49–56. doi: 10.1016/0003-9861(64)90155-9. [DOI] [PubMed] [Google Scholar]
  2. BONTING S. L., POLLAK V. E., MUEHRCKE R. C., KARK R. M. Quantitative histochemistry of the nephron. II. Alkaline phosphatase activity in man and other species. J Clin Invest. 1960 Sep;39:1372–1380. doi: 10.1172/JCI104156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bonting S. L., Pollak V. E., Muehrcke R. C., Kark R. M. QUANTITATIVE HISTOCHEMISTRY OF THE NEPHRON. III. LACTIC DEHYDROGENASE ACTIVITY IN MAN AND OTHER SPECIES. J Clin Invest. 1960 Sep;39(9):1381–1385. doi: 10.1172/JCI104157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CANESSA-FISCHER M., SHALHOUB R., GLABMANS, DEHAAS J., PITTS R. F. Effects of infusions of ammonia, amides, and amino acids on excretion of ammonia. Am J Physiol. 1963 Feb;204:192–196. doi: 10.1152/ajplegacy.1963.204.2.192. [DOI] [PubMed] [Google Scholar]
  5. DAVIES B. M. A., YUDKIN J. Studies in biochemical adaptation; the origin or urinary ammonia as indicated by the effect of chronic acidosis and alkalosis on some renal enzymes in the rat. Biochem J. 1952 Nov;52(3):407–412. doi: 10.1042/bj0520407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KAMIN H., HANDLER P. The metabolism of parenterally administered amino acids. III. Ammonia formation. J Biol Chem. 1951 Dec;193(2):873–880. [PubMed] [Google Scholar]
  7. Krebs H. A. Metabolism of amino-acids: Deamination of amino-acids. Biochem J. 1935 Jul;29(7):1620–1644. doi: 10.1042/bj0291620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LOWY R., DECLOITRE F., BRIGANT L. M'ETHODE DE FRACTIONNEMENT ET DE DOSAGE DES COMPOS'ES PHOSPHOR'ES TISSULAIRES. Enzymol Biol Clin (Basel) 1964;36:39–50. [PubMed] [Google Scholar]
  9. MATTENHEIMER H., DEBRUIN H. An ultramicro method for determination of carbonic anhydrase activity. Anal Biochem. 1962 Sep;4:222–230. doi: 10.1016/0003-2697(62)90005-2. [DOI] [PubMed] [Google Scholar]
  10. MATTENHEIMER H., POLLAK V. E., DEBRUIN H. QUANTITATIVE HISTOCHEMISTRY OF THE NEPHRON IX. DISTRIBUTION AND ACTIVITY OF VARIOUS ENZYMES IN THE KIDNEY OF THE DOG. Enzymol Biol Clin (Basel) 1964;23:107–120. doi: 10.1159/000458020. [DOI] [PubMed] [Google Scholar]
  11. MATTENHEIMER H., POLLAK V. E., MUEHRCKE R. C., KARK R. M. QUANTITATIVE ENZYMVERTEILUNGSMUSTER IM NEPHRON. Verh Dtsch Ges Inn Med. 1964;70:579–582. [PubMed] [Google Scholar]
  12. Mattenheimer H., DeBruin H. Glutaminases. An ultramicro method for the determination of glutaminase activity, and a reinvestigation of optimum assay conditions in the kidney of man, dog and rat. Enzymol Biol Clin (Basel) 1964;4(2):65–83. [PubMed] [Google Scholar]
  13. Meldrum N. U., Roughton F. J. Carbonic anhydrase. Its preparation and properties. J Physiol. 1933 Dec 5;80(2):113–142. doi: 10.1113/jphysiol.1933.sp003077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. OWEN E. E., ROBINSON R. R. Amino acid extraction and ammonia metabolism by the human kidney during the prolonged administration of ammonium chloride. J Clin Invest. 1963 Feb;42:263–276. doi: 10.1172/JCI104713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. PITTS R. F., DEHAAS J., KLEIN J. Relation of renal amino and amide nitrogen extraction to ammonia production. Am J Physiol. 1963 Feb;204:187–191. doi: 10.1152/ajplegacy.1963.204.2.187. [DOI] [PubMed] [Google Scholar]
  16. RECTOR F. C., Jr, ORLOFF J. The effect of the administration of sodium bicarbonate and ammonium chloride on the excretion and production of ammonia; the absence of alterations in the activity of renal ammonia-producing enzymes in the dog. J Clin Invest. 1959 Feb;38(2):366–372. doi: 10.1172/JCI103810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. RECTOR F. C., Jr, SELDIN D. W., COPENHAVER J. H. The mechanism of ammonia excretion during ammonium chloride acidosis. J Clin Invest. 1955 Jan;34(1):20–26. doi: 10.1172/JCI103058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. RICHTERICH-VAN BAERLE R., GOLDSTEIN L., DEARBORN E. H. Relation of ammonia excretion to urine pH in the guinea pig. Science. 1956 Jul 13;124(3211):74–74. doi: 10.1126/science.124.3211.74. [DOI] [PubMed] [Google Scholar]
  19. RICHTERICH R. W., GOLDSTEIN L. Distribution of glutamine metabolizing enzymes and production of urinary ammonia in the mammalian kidney. Am J Physiol. 1958 Nov;195(2):316–320. doi: 10.1152/ajplegacy.1958.195.2.316. [DOI] [PubMed] [Google Scholar]
  20. ROBIN E. D. Of men and mitochondria--intracellular and subcellular acid-base relations. N Engl J Med. 1961 Oct 19;265:780–785. doi: 10.1056/NEJM196110192651605. [DOI] [PubMed] [Google Scholar]
  21. Sartorius O. W., Roemmelt J. C., Pitts R. F., Calhoon D., Miner P. THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. IV. THE NATURE OF THE RENAL COMPENSATIONS IN AMMONIUM CHLORIDE ACIDOSIS. J Clin Invest. 1949 May;28(3):423–439. doi: 10.1172/JCI102087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. VATES T. S., Jr, BONTING S. L., OPPELT W. W. NA-K ACTIVATED ADENOSINE TRIPHOSPHATASE FORMATION OF CEREBROSPINAL FLUID IN THE CAT. Am J Physiol. 1964 May;206:1165–1172. doi: 10.1152/ajplegacy.1964.206.5.1165. [DOI] [PubMed] [Google Scholar]
  23. WACKER G. R., ZARKOWSKY H. S., BURCH H. B. Changes in kidney enzymes of rats after birth. Am J Physiol. 1961 Feb;200:367–369. doi: 10.1152/ajplegacy.1961.200.2.367. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES