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. 1965 Feb;44(2):302–314. doi: 10.1172/JCI105144

The Role of Proaccelerin in Human Blood Coagulation. Evidence that Proaccelerin Is Converted to a Prothrombin-converting Principle by Activated Stuart Factor: With Notes on the Anticoagulant Action of Soybean Trypsin Inhibitor, Protamine Sulfate, and Hexadimethrine Bromide*

Robert T Breckenridge 1,, Oscar D Ratnoff 1,
PMCID: PMC292478  PMID: 16695912

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER B., GOLDSTEIN R. Parahemophilia in three siblings (Owren's disease). Am J Med. 1952 Sep;13(3):255–272. doi: 10.1016/0002-9343(52)90281-7. [DOI] [PubMed] [Google Scholar]
  2. BERGSAGEL D. E., HOUGIE C. Intermediate stages in the formation of blood thromboplastin. Br J Haematol. 1956 Apr;2(2):113–129. doi: 10.1111/j.1365-2141.1956.tb06820.x. [DOI] [PubMed] [Google Scholar]
  3. BRECKENRIDGE R. T., RATNOFF C. D. Studies on the nature of the circulating anticoagulant directed against antihemophilic factor: with notes on an assay for anthemophilic factor. Blood. 1962 Aug;20:137–149. [PubMed] [Google Scholar]
  4. BRECKENRIDGE R. T., RATNOFF O. D. STUDIES ON THE SITE OF ACTION OF A CIRCULATING ANTICOAGULANT IN DISSEMINATED LUPUS ERYTHEMATOSUS. EVIDENCE THAT THIS ANTICOAGULANT INHIBITS THE REACTION BETWEEN ACTIVATED STUART FACTOR (FACTOR X) AND PROACCELERIN (FACTOR V). Am J Med. 1963 Dec;35:813–819. doi: 10.1016/0002-9343(63)90243-2. [DOI] [PubMed] [Google Scholar]
  5. DAVIE E. W., RATNOFF O. D. WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING. Science. 1964 Sep 18;145(3638):1310–1312. doi: 10.1126/science.145.3638.1310. [DOI] [PubMed] [Google Scholar]
  6. ESNOUF M. P., WILLIAMS W. J. The isolation and purification of a bovine-plasma protein which is a substrate for the coagulant fraction of Russell's-viper venom. Biochem J. 1962 Jul;84:62–71. doi: 10.1042/bj0840062. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FLYNN J. E., COON R. W. Fundamentals of blood clotting. Annu Rev Physiol. 1952;14:205–234. doi: 10.1146/annurev.ph.14.030152.001225. [DOI] [PubMed] [Google Scholar]
  8. GLENDENING M. B., PAGE E. W. The site of inhibition of blood clotting by soy bean trypsin inhibitor. J Clin Invest. 1951 Nov;30(11):1298–1304. doi: 10.1172/JCI102549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Glazko A. J. EFFECT OF BLOOD PROTEASE AND TRYPSIN INHIBITOR ON THE CLOTTING MECHANISM. J Clin Invest. 1947 May;26(3):364–369. doi: 10.1172/JCI101818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HARDISTY R. M. The reaction of blood coagulation factors with brain extract. Br J Haematol. 1955 Jul;1(3):323–332. doi: 10.1111/j.1365-2141.1955.tb05514.x. [DOI] [PubMed] [Google Scholar]
  11. HJORT P. F. Intermediate reactions in the coagulation of blood with tissue thromboplastin; convertin, accelerin, prothrombinase. Scand J Clin Lab Invest. 1957;9 (Suppl 27):1–183. [PubMed] [Google Scholar]
  12. HOUGIE C. A simple assay method for factor X (Stuart-Prower factor). Proc Soc Exp Biol Med. 1962 Mar;109:754–756. doi: 10.3181/00379727-109-27328. [DOI] [PubMed] [Google Scholar]
  13. HOUGIE C. Anticoagulant action of protamine sulphate. Proc Soc Exp Biol Med. 1958 May;98(1):130–133. doi: 10.3181/00379727-98-23963. [DOI] [PubMed] [Google Scholar]
  14. HOUGIE C. The role of factor V in the formation of blood thromboplastin. J Lab Clin Med. 1957 Jul;50(1):61–68. [PubMed] [Google Scholar]
  15. KIMURA E. T., YOUNG P. R., STEIN R. J., RICHARDS R. K. Some pharmacologic characteristics of hexadimethrine bromide (polybrene); a new antiheparin agent. Toxicology. 1959 Mar;1(2):185–202. doi: 10.1016/0041-008x(59)90139-5. [DOI] [PubMed] [Google Scholar]
  16. LEPOW I. H., PILLEMER L., RATNOFF O. D. The influence of calcium ions on the inactivation of human complement and its components by plasmin. J Exp Med. 1953 Sep;98(3):277–289. doi: 10.1084/jem.98.3.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MACFARLANE R. G. AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER. Nature. 1964 May 2;202:498–499. doi: 10.1038/202498a0. [DOI] [PubMed] [Google Scholar]
  18. MACFARLANE R. G. The coagulant action of Russell's viper venom; the use of antivenom in defining its reaction with a serum factor. Br J Haematol. 1961 Oct;7:496–511. doi: 10.1111/j.1365-2141.1961.tb00358.x. [DOI] [PubMed] [Google Scholar]
  19. MARKWARDT F., HOFFMANN A., LANDMANN H. VERSUCHE ZUR HEMMUNG DER AUTOPROTHROMBIN C-WIRKUNG. Thromb Diath Haemorrh. 1964 Apr 15;11:230–233. [PubMed] [Google Scholar]
  20. MILSTONE J. H. Effect of blood thrombokinase, as influenced by soy bean trypsin inhibitor, ultracentrifugation, and accessory factors. J Gen Physiol. 1955 Jul 20;38(6):757–769. doi: 10.1085/jgp.38.6.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MILSTONE J. H., OULIANOFF N., MILSTONE V. K. OUTSTANDING CHARACTERISTICS OF THROMBOKINASE ISOLATED FROM BOVINE PLASMA. J Gen Physiol. 1963 Nov;47:315–327. doi: 10.1085/jgp.47.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. MILSTONE J. H. On the evolution of blood clotting theory. Medicine (Baltimore) 1952 Dec;31(4):411–447. doi: 10.1097/00005792-195212000-00004. [DOI] [PubMed] [Google Scholar]
  23. MILSTONE J. H. Thrombokinase of the blood as trypsin-like enzyme. J Gen Physiol. 1962 Mar;45(4):103–113. doi: 10.1085/jgp.45.4.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. OWREN P. A. Prothrombin and accessory factors; clinical significance. Am J Med. 1953 Feb;14(2):201–215. doi: 10.1016/0002-9343(53)90019-9. [DOI] [PubMed] [Google Scholar]
  25. PAPAHADJOPOULOS D., HOUGIE C., HANAHAN D. J. PURIFICATION AND PROPERTIES OF BOVINE FACTOR V: A CHANGE OF MOLECULAR SIZE DURING BLOOD COAGULATION. Biochemistry. 1964 Feb;3:264–270. doi: 10.1021/bi00890a021. [DOI] [PubMed] [Google Scholar]
  26. PEDEN J. C., Jr, PEACOCK A. C. The coagulation of blood by Russell's viper venom; a reaction between Russell's viper venom and beef serum factors. J Lab Clin Med. 1958 Jul;52(1):101–108. [PubMed] [Google Scholar]
  27. QUICK A. J. The assay and properties of labile factor (factor V). J Clin Pathol. 1960 Nov;13:457–462. doi: 10.1136/jcp.13.6.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. RATNOFF O. D., DAVIE E. W., MALLETT D. L. Studies on the action of Hageman factor: evidence that activated Hageman factor in turn activates plasma thromboplastin antecedent. J Clin Invest. 1961 May;40:803–819. doi: 10.1172/JCI104314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. SEEGERS W. H., MARCINIAK E. Autoprothrombin C in irregular blood clotting. Thromb Diath Haemorrh. 1962 Oct 1;8:1–20. [PubMed] [Google Scholar]
  30. SHANBERGE J. N., REGAN E. E., TALARICO L., BUSIEK B. The effect of Polybrene on blood coagulation. In vitro. J Lab Clin Med. 1961 Jul;58:23–33. [PubMed] [Google Scholar]
  31. SHYLMAN N. R., HEARON J. Z. Kinetics of conversion of prothrombin to thrombin by biological activators. I. Demonstration of a prothrombin derivative which reacts with proteolytic enzyme inhibitors. J Biol Chem. 1963 Jan;238:155–164. [PubMed] [Google Scholar]
  32. SOULIER J. P. A new adsorption agent for coagulation factors. J Clin Pathol. 1959 Jul;12:303–306. doi: 10.1136/jcp.12.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. SPAET T. H., CINTRON J. Pathways to blood coagulation product I formation. Blood. 1963 Jun;21:745–754. [PubMed] [Google Scholar]
  34. WILLIAMS W. J., ESNOUF M. P. The fractionation of Russell's-viper (Vipera russellii) venom with special reference to the coagulant protein. Biochem J. 1962 Jul;84:52–62. doi: 10.1042/bj0840052. [DOI] [PMC free article] [PubMed] [Google Scholar]

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