Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1965 Apr;44(4):574–581. doi: 10.1172/JCI105170

Haptoglobin Synthesis. I. In Vivo Studies of the Production of Haptoglobin, Fibrinogen, and γ-Globulin by the Canine Liver*

Chester A Alper 1,2,3,4,†, John H Peters 1,2,3,4,‡, Alan G Birtch 1,2,3,4,§, Frank H Gardner 1,2,3,4,ǁ
PMCID: PMC292528  PMID: 14278173

Full text

PDF
574

Images in this article

575Image
on p.575

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON A. C., REES W. A. The binding of haemoglobin by plasma proteins (haptoglobins); its bearing on the renal threshold for haemoglobin and the aetiology of haemoglobinuria. Br Med J. 1957 Nov 16;2(5054):1137–1143. doi: 10.1136/bmj.2.5054.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CAMERON C. B. The liver and steroid hormone metabolism. Br Med Bull. 1957 May;13(2):119–125. doi: 10.1093/oxfordjournals.bmb.a069587. [DOI] [PubMed] [Google Scholar]
  3. CHAPLIN H., Jr, MOLLISON P. L. Red cell life-span in nephritis and in hepatic cirrhosis. Clin Sci. 1953 Nov;12(4):351–360. [PubMed] [Google Scholar]
  4. COONS A. H., LEDUC E. H., CONNOLLY J. M. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J Exp Med. 1955 Jul 1;102(1):49–60. doi: 10.1084/jem.102.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HAMASHIMA Y., HARTER J. G., COONS A. H. THE LOCALIZATION OF ALBUMIN AND FIBRINOGEN IN HUMAN LIVER CELLS. J Cell Biol. 1964 Feb;20:271–279. doi: 10.1083/jcb.20.2.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HYMAN G. A., SOUTHWORTH H. Hemolytic anemia associated with liver disease. Am J Med Sci. 1951 Apr;221(4):448–456. doi: 10.1097/00000441-195104000-00014. [DOI] [PubMed] [Google Scholar]
  7. JANDL J. H. The anemia of liver disease: observations on its mechanism. J Clin Invest. 1955 Mar;34(3):390–404. doi: 10.1172/JCI103087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. JAYLE M. F., BADIN J. Signification et intéret clinique de la formule protéique du plasma sanguin. Presse Med. 1953 Mar 11;61(17):343–345. [PubMed] [Google Scholar]
  9. JAYLE M. F., BOUSSIER G. Les séromucoïdes du sang: leurs relations avec les mucoprotéines de la substance fondamentale du tissu conjonctif. Expos Annu Biochim Med. 1955;17:157–194. [PubMed] [Google Scholar]
  10. JAYLE M. F., VALLIN J. Variations de la formule protéique du plasma au cours des affections hépatiques. Sem Hop. 1952 Oct 22;28(78):3133–3138. [PubMed] [Google Scholar]
  11. JONES P. N., WEINSTEIN I. M., ETTINGER R. H., CAPPS R. B. Decreased red cell survival associated with liver disease; use of radioactive sodium chromate in measurement of red cell survival. AMA Arch Intern Med. 1955 Jan;95(1):93–102. doi: 10.1001/archinte.1955.00250070109013. [DOI] [PubMed] [Google Scholar]
  12. KUKRAL J. C., KERTH J. D., PANCNER R. J., CROMER D. W., HENEGAR G. C. Plasma protein synthesis in the normal dog and after total hepatectomy. Surg Gynecol Obstet. 1961 Sep;113:360–372. [PubMed] [Google Scholar]
  13. LAURELL C. B., LAURELL S., SKOOG N. Buffer composition in paper electrophoresis; considerations on its influence, with special reference to the interaction between small ions and proteins. Clin Chem. 1956 Apr;2(2):99–111. [PubMed] [Google Scholar]
  14. LAURELL C. B., NYMAN M. Studies on the serum haptoglobin level in hemoglobinemia and its influence on renal excretion of hemoglobin. Blood. 1957 Jun;12(6):493–506. [PubMed] [Google Scholar]
  15. LAURELL C. B. Purification and properties of different haptoglobins. Clin Chim Acta. 1959 Jan;4(1):79–81. doi: 10.1016/0009-8981(59)90085-3. [DOI] [PubMed] [Google Scholar]
  16. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  17. MERRILL D. A., KIRKPATRICK C. H., WILSON W. E., RILEY C. M. CHANGE IN SERUM HAPTOGLOBIN TYPE FOLLOWING HUMAN LIVER TRANSPLANTATION. Proc Soc Exp Biol Med. 1964 Jul;116:748–751. doi: 10.3181/00379727-116-29363. [DOI] [PubMed] [Google Scholar]
  18. MIALE J. B., KENT J. W. Serum haptoglobin in rabbits after subcutaneous injection of Freund's adjuvant or turpentine. Proc Soc Exp Biol Med. 1962 Dec;111:589–590. doi: 10.3181/00379727-111-27863. [DOI] [PubMed] [Google Scholar]
  19. MILLER L. L., BALE W. F. Synthesis of all plasma protein fractions except gamma globulins by the liver; the use of zone electrophoresis and lysine-epsilon-C14 to define the plasma proteins synthesized by the isolated perfused liver. J Exp Med. 1954 Feb;99(2):125–132. doi: 10.1084/jem.99.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MILLER L. L., BLY C. G., BALE W. F. Plasma and tissue proteins produced by non-hepatic rat organs as studied with lysine-epsilon-C14; gamma globulins the chief plasma protein fraction produced by non-hepatic tissues. J Exp Med. 1954 Feb;99(2):133–153. doi: 10.1084/jem.99.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MURRAY R. K., CONNELL G. E. Elevation of serum haptoglobin in rabbits in response to experimental inflammation. Nature. 1960 Apr 2;186:86–86. doi: 10.1038/186086a0. [DOI] [PubMed] [Google Scholar]
  22. NATHAN D. G., GABUZDA T. G., GARDNER F. H. LIQUID SCINTILLATION COUNTING OF C14-LABELED HEMOGLOBIN AND HEMIN BY A MODIFIED SCHOENIGER TECHNIQUE. J Lab Clin Med. 1963 Sep;62:511–516. [PubMed] [Google Scholar]
  23. NOYES W. D., LAURELL C. B. The in vitro stability of the haptoglobin-hemoglobin complex. Scand J Clin Lab Invest. 1961;13:625–627. doi: 10.3109/00365516109137335. [DOI] [PubMed] [Google Scholar]
  24. POULIK M. D. Starch gel electrophoresis in a discontinous system of buffers. Nature. 1957 Dec 28;180(4600):1477–1479. doi: 10.1038/1801477a0. [DOI] [PubMed] [Google Scholar]
  25. ROWE D. S., SOOTHILL J. F. Observations on globin, haemoglobin and haptoglobin using a rabbit antiglobin serum. Nature. 1960 Jun 18;186:975–976. doi: 10.1038/186975a0. [DOI] [PubMed] [Google Scholar]
  26. SCHUMACHER G. [On haptoglobin and non-haptoglobin components of alpha2 globulin in inflammatory processes and in pregnancy]. Geburtshilfe Frauenheilkd. 1962 Oct;22:1006–1010. [PubMed] [Google Scholar]
  27. SHOEMAKER W. C., WALKER W. F., VAN ITALLIE T. B., MOORE F. D. A method for simultaneous catheterization of major hepatic vessels in a chronic canine preparation. Am J Physiol. 1959 Feb;196(2):311–314. doi: 10.1152/ajplegacy.1959.196.2.311. [DOI] [PubMed] [Google Scholar]
  28. SMITHIES O. An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. Biochem J. 1959 Mar;71(3):585–587. doi: 10.1042/bj0710585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. WILLIAMS C. A., Jr, ASOFSKY R., THORBECKE G. J. PLASMA PROTEIN FORMATION IN VITRO BY TISSUES FROM MICE INFECTED WITH STAPHYLOCOCCI. J Exp Med. 1963 Aug 1;118:315–326. doi: 10.1084/jem.118.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. ZIEVE L. Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann Intern Med. 1958 Mar;48(3):471–496. doi: 10.7326/0003-4819-48-3-471. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES