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. 1965 May;44(5):789–800. doi: 10.1172/JCI105191

Functional Significance of a Low Pulmonary Diffusing Capacity for Carbon Monoxide*

Robert L Johnson Jr 1,, Harold F Taylor 1,, Arthur C DeGraff Jr 1
PMCID: PMC292555  PMID: 14276136

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUSTRIAN R., McCLEMENT J. H., RENZETTI A. D., Jr, DONALD K. W., RILEY R. L., COURNAND A. Clinical and physiologic features of some types of pulmonary diseases with impairment of alveolar-capillary diffusion; the syndrome of "alveolar-capillary block". Am J Med. 1951 Dec;11(6):667–685. doi: 10.1016/0002-9343(51)90019-8. [DOI] [PubMed] [Google Scholar]
  2. BEUMER H. M., DEFARES J. G. Remarks on the accuracy of Bohr's procedure. J Appl Physiol. 1958 Jan;12(1):140–141. doi: 10.1152/jappl.1958.12.1.140. [DOI] [PubMed] [Google Scholar]
  3. Darling R. C., Cournand A., Richards D. W., Domanski B. STUDIES ON INTRAPULMONARY MIXTURE OF GASES. V. FORMS OF INADEQUATE VENTILATION IN NORMAL AND EMPHYSEMATOUS LUNGS, ANALYZED BY MEANS OF BREATHING PURE OXYGEN. J Clin Invest. 1944 Jan;23(1):55–67. doi: 10.1172/JCI101473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FORSTER R. E., FOWLER W. S., BATES D. V. Considerations on the uptake of carbon monoxide by the lungs. J Clin Invest. 1954 Aug;33(8):1128–1134. doi: 10.1172/JCI102986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FOWLER W. S. Lung function studies; uneven pulmonary ventilation in normal subjects and in patients with pulmonary disease. J Appl Physiol. 1949 Dec;2(6):283–299. doi: 10.1152/jappl.1949.2.6.283. [DOI] [PubMed] [Google Scholar]
  6. HAMER N. A. Variations in the components of the diffusing capacity as the lung expands. Clin Sci. 1963 Apr;24:275–285. [PubMed] [Google Scholar]
  7. JOHNSON R. L., Jr, SPICER W. S., BISHOP J. M., FORSTER R. E. Pulmonary capillary blood volume, flow and diffusing capacity during exercise. J Appl Physiol. 1960 Sep;15:893–902. doi: 10.1152/jappl.1960.15.5.893. [DOI] [PubMed] [Google Scholar]
  8. JOHNSON R. L., Jr, TAYLOR H. F., LAWSON W. H., Jr MAXIMAL DIFFUSING CAPACITY OF THE LUNG FOR CARBON MONOXIDE. J Clin Invest. 1965 Mar;44:349–355. doi: 10.1172/JCI105148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LAWSON W. H., Jr, JOHNSON R. L., Jr Gas chromatography in measuring pulmonary blood flow and diffusing capacity. J Appl Physiol. 1962 Jan;17:143–147. doi: 10.1152/jappl.1962.17.1.143. [DOI] [PubMed] [Google Scholar]
  10. LEWIS B. M., LIN T. H., NOE F. E., HAYFORD-WELSING E. J. The measurement of pulmonary diffusing capacity for carbon monoxide by a rebreathing method. J Clin Invest. 1959 Nov;38:2073–2086. doi: 10.1172/JCI103985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LINDERHOLM H. Diffusing capacity of the lungs as a limiting factor for physical working capacity. Acta Med Scand. 1959 Feb 7;163(1):61–84. doi: 10.1111/j.0954-6820.1959.tb10383.x. [DOI] [PubMed] [Google Scholar]
  12. MARSHALL R. A comparison of methods of measuring the diffusing capacity of the lungs for carbon monoxide; investigation by fractional analysis of the alveolar air. J Clin Invest. 1958 Mar;37(3):394–408. doi: 10.1172/JCI103619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MILLER W. F., JOHNSON R. L., Jr, WU N. Relationships between fast vital capacity and various timed expiratory capacities. J Appl Physiol. 1959 Mar;14(2):157–163. doi: 10.1152/jappl.1959.14.2.157. [DOI] [PubMed] [Google Scholar]
  14. MITCHELL J. H., SPROULE B. J., CHAPMAN C. B. The physiological meaning of the maximal oxygen intake test. J Clin Invest. 1958 Apr;37(4):538–547. doi: 10.1172/JCI103636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McGRATH M. W., THOMSON M. L. The effect of age, body size and lung volume change on alveolar-capillary permeability and diffusing capacity in man. J Physiol. 1959 Jun 11;146(3):572–582. doi: 10.1113/jphysiol.1959.sp006212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. NEEDHAM C. D., ROGAN M. C., McDONALD I. Normal standards for lung volumes, intrapulmonary gas-mixing, and maximum breathing capacity. Thorax. 1954 Dec;9(4):313–325. doi: 10.1136/thx.9.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. PIIPER J. Variations of ventilation and diffusing capacity to perfusion determining the alveolar-arterial O2 difference: theory. J Appl Physiol. 1961 May;16:507–510. doi: 10.1152/jappl.1961.16.3.507. [DOI] [PubMed] [Google Scholar]
  18. ROUGHTON F. J., FORSTER R. E., CANDER L. Rate at which carbon monoxide replaces oxygen from combination with human hemoglobin in solution and in the red cell. J Appl Physiol. 1957 Sep;11(2):269–276. doi: 10.1152/jappl.1957.11.2.269. [DOI] [PubMed] [Google Scholar]
  19. ROUGHTON F. J., FORSTER R. E. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J Appl Physiol. 1957 Sep;11(2):290–302. doi: 10.1152/jappl.1957.11.2.290. [DOI] [PubMed] [Google Scholar]
  20. SEVERINGHAUS J. W. Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood. J Appl Physiol. 1958 May;12(3):485–486. doi: 10.1152/jappl.1958.12.3.485. [DOI] [PubMed] [Google Scholar]
  21. SHEPARD R. H. Effect of pulmonary diffusing capacity on exercise tolerance. J Appl Physiol. 1958 May;12(3):487–488. doi: 10.1152/jappl.1958.12.3.487. [DOI] [PubMed] [Google Scholar]
  22. STAUB N. C., BISHOP J. M., FORSTER R. E. Importance of diffusion and chemical reaction rates in O2 uptake in the lung. J Appl Physiol. 1962 Jan;17:21–27. doi: 10.1152/jappl.1962.17.1.21. [DOI] [PubMed] [Google Scholar]
  23. Stein M., Kimbel P., Johnson R. L. PULMONARY FUNCTION IN HYPERTHYROIDISM. J Clin Invest. 1961 Feb;40(2):348–363. doi: 10.1172/JCI104262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. WEST J. B., LAHIRI S., GILL M. B., MILLEDGE J. S., PUGH L. G., WARD M. P. Arterial oxygen saturation during exercise at high altitude. J Appl Physiol. 1962 Jul;17:617–621. doi: 10.1152/jappl.1962.17.4.617. [DOI] [PubMed] [Google Scholar]

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