Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1965 Jul;44(7):1171–1186. doi: 10.1172/JCI105224

Prolonged Infusions of Angiotensin II and Norepinephrine and Blood Pressure, Electrolyte Balance, and Aldosterone and Cortisol Secretion in Normal Man and in Cirrhosis with Ascites*

Richard P Ames 1,†, Abraham J Borkowski 1,‡, Alfred M Sicinski 1,§, John H Laragh 1,ǁ
PMCID: PMC292592  PMID: 14328394

Full text

PDF
1171

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUGUST J. T., NELSON D. H., THORN G. W. Response of normal subjects to large amounts of aldosterone. J Clin Invest. 1958 Nov;37(11):1549–1555. doi: 10.1172/JCI103747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BIRON P., CHRETIEN M., KOIW E., GENEST J. Effects of angiotensin infusions on aldosterone and electrolyte excretion in normal subjects and patients with hypertension and adrenocortical disorders. Br Med J. 1962 Jun 9;1(5292):1569–1575. doi: 10.1136/bmj.1.5292.1569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BLAIR-WEST J. R., COGHLAN J. P., DENTON D. A., GODING J. R., MUNRO J. A., PETERSON R. E., WINTOUR M. Humoral stimulation of adrenal cortical secretion. J Clin Invest. 1962 Aug;41:1606–1627. doi: 10.1172/JCI104619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BOCK H. D., KRECKE H. J. Die Wirkung von synthetischem Hypertensin II auf die PAH- und Inulin-Clearánce, die renale Hamodynamik und die Diurese beim Menschen. Klin Wochenschr. 1958 Jan 15;36(2):69–74. doi: 10.1007/BF01486247. [DOI] [PubMed] [Google Scholar]
  5. BOCK K. D., DENGLER H., KRECKE H. J., REICHEL G. Untersuchungen über die Wirkung von synthetischem Hypertensin II auf Elektrolythaushalt, Nierenfunktion und Kreislauf beim Menschen. Klin Wochenschr. 1958 Sep 1;36(17):808–814. doi: 10.1007/BF01481948. [DOI] [PubMed] [Google Scholar]
  6. BORST J. G., BORST-DE GEUS A. Hypertension explained by Starling's theory of circulatory homoeostasis. Lancet. 1963 Mar 30;1(7283):677–682. doi: 10.1016/s0140-6736(63)91443-0. [DOI] [PubMed] [Google Scholar]
  7. BROWN J. J., CHAPUIS G., ROBERTSON J. I. THE EFFECT OF PROLONGED INTRAVENOUS INFUSION OF ANGIOTENSIN IN THE RABBIT. Clin Sci. 1964 Feb;26:165–175. [PubMed] [Google Scholar]
  8. CARPENTER C. C., DAVIS J. O., AYERS C. R. Relation of renin, angiotensin II, and experimental renal hypertension to aldosterone secretion. J Clin Invest. 1961 Nov;40:2026–2042. doi: 10.1172/JCI104429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DAVIS J. O., AYERS C. R., CARPENTER C. C. Renal origin of an aldosterone-stimulating hormone in dogs with thoracic caval constriction and in sodium-depleted dogs. J Clin Invest. 1961 Aug;40:1466–1474. doi: 10.1172/JCI104377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DAVIS J. O., CARPENTER C. C., AYERS C. R., HOLMAN J. E., BAHN R. C. Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J Clin Invest. 1961 Apr;40:684–696. doi: 10.1172/JCI104301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. DAVIS J. O., HARTROFT P. M., TITUS E. O., CARPENTER C. C., AYERS C. R., SPIEGEL H. E. The role of the renin-angiotensin system in the control of aldosterone secretion. J Clin Invest. 1962 Feb;41:378–389. doi: 10.1172/JCI104492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. DAVIS J. O., URQUHART J., HIGGINS J. T., Jr RENIN, ANGIOTENSIN AND ALDOSTERONE IN EXPERIMENTAL SECONDARY HYPERALDOSTERONISM. Can Med Assoc J. 1964 Jan 25;90:245–248. [PMC free article] [PubMed] [Google Scholar]
  13. DEANE H. W., MASSON G. M. C. Adrenal cortical changes in rats with various types of experimental hypertension. J Clin Endocrinol Metab. 1951 Feb;11(2):193–208. doi: 10.1210/jcem-11-2-193. [DOI] [PubMed] [Google Scholar]
  14. DICKINSON C. J., LAWRENCE J. R. A slowly developing pressor response to small concentrations of angiotensin. Its bearing on the pathogenesis of chronic renal hypertension. Lancet. 1963 Jun 22;1(7295):1354–1356. doi: 10.1016/s0140-6736(63)91929-9. [DOI] [PubMed] [Google Scholar]
  15. DUNIHUE F. W., VAN ROBERTSON W. B. The effect of desoxycorticosterone acetate and of sodium on the juxtaglomerular apparatus. Endocrinology. 1957 Sep;61(3):293–299. doi: 10.1210/endo-61-3-293. [DOI] [PubMed] [Google Scholar]
  16. FINNERTY F. A., Jr, MASSARO G. D., CHUPKOVICH V., TUCKMAN J. Evaluation of the pressor, cardiac, and renal hemodynamic properties of angiotensin II in man. Circ Res. 1961 Mar;9:256–263. doi: 10.1161/01.res.9.2.256. [DOI] [PubMed] [Google Scholar]
  17. GANONG W. F., MULROW P. J., BORYCZKA A., CERA G. Evidence for a direct effect of angiotensin-II on adrenal cortex of the dog. Proc Soc Exp Biol Med. 1962 Feb;109:381–384. doi: 10.3181/00379727-109-27210. [DOI] [PubMed] [Google Scholar]
  18. GENEST J., BIRON P., KOIW E., NOWACZYNSKI W., CHRETIEN M., BOUCHER R. Adrenocortical hormones in human hypertension and their relation to angiotensin. Circ Res. 1961 May;9:775–791. doi: 10.1161/01.res.9.3.775. [DOI] [PubMed] [Google Scholar]
  19. GORNEL D. L., LANCESTREMERE R. G., PAPPER S., LOWENSTEIN L. M. Acute changes in renal excretion of water and solute in patients with Laennec's cirrhosis, induced by the administration of the pressor amine, metaraminol. J Clin Invest. 1962 Mar;41:594–603. doi: 10.1172/JCI104514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. GROSS F., BOCK K. D. Some contributions to the pharmacology of synthetic angiotensin. Circulation. 1962 Jan;25:193–199. doi: 10.1161/01.cir.25.1.193. [DOI] [PubMed] [Google Scholar]
  21. GROSS F., LOUSTALOT P., SULSER F. Die Bedeutung von Kochsalz für den Cortexon-Hochdruck der Ratte und den Gehalt der Nieren an pressorischen Substanzen. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1956;229(4):381–388. [PubMed] [Google Scholar]
  22. GROSS F., SULSER F. Der Einfluss der Nebennieren auf die blutdrucksteigernde Wirkung von Renin und auf pressorische Substanzen in den Nieren. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;230(3):274–283. [PubMed] [Google Scholar]
  23. HARTROFT P. M., HARTROFT W. S. Studies on renal juxtaglomerular cells. I. Variations produced by sodium chloride and desoxycorticosterone acetate. J Exp Med. 1953 Mar;97(3):415–429. doi: 10.1084/jem.97.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. HARTROFT P. M., HARTROFT W. S. Studies on renal juxtaglomerular cells. II. Correlation of the degree of granulation of juxtaglomerular cells with width of the zone glomerulosa of the adrenal cortex. J Exp Med. 1955 Aug 1;102(2):205–212. doi: 10.1084/jem.102.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. HOWARD J. E. HYPERTENSION AS RELATED TO RENAL ISCHEMIA. Circulation. 1964 May;29:657–665. doi: 10.1161/01.cir.29.5.657. [DOI] [PubMed] [Google Scholar]
  26. JOHNSON W. P., BRUCE R. A. Hemodynamic and metabolic effects of angiotensin II during rest and exercise in normal healthy subjects. Am Heart J. 1962 Feb;63:212–218. doi: 10.1016/0002-8703(62)90197-7. [DOI] [PubMed] [Google Scholar]
  27. LARAGH J. H., ANGERS M., KELLY W. G., LIEBERMAN S. Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II, and others on the secretory rate of aldosterone in man. JAMA. 1960 Sep 17;174:234–240. doi: 10.1001/jama.1960.03030030014003. [DOI] [PubMed] [Google Scholar]
  28. LARAGH J. H. Hormones and the pathogenesis of congestive heart failure: vasopressin, aldosterone, and angiotensin II. Further evidence for renal-adrenal interaction from studies in hypertension and in cirrhosis. Circulation. 1962 Jun;25:1015–1023. doi: 10.1161/01.cir.25.6.1015. [DOI] [PubMed] [Google Scholar]
  29. LARAGH J. H. Interrelationships between angiotensin, norepinephrine, epinephrine, aldosterone secretion, and electrolyte metabolism in man. Circulation. 1962 Jan;25:203–211. doi: 10.1161/01.cir.25.1.203. [DOI] [PubMed] [Google Scholar]
  30. LARAGH J. H. The role of aldosterone in man. Evidence for regulation of electrolyte balance and arterial pressure by a renal-adrenal system which may be involved in malignant hypertension. JAMA. 1960 Sep 17;174:293–295. doi: 10.1001/jama.1960.63030030007014. [DOI] [PubMed] [Google Scholar]
  31. LARAGH J. H., ULICK S., JANUSZEWICZ V., DEMING Q. B., KELLY W. G., LIEBERMAN S. Aldosterone secretion and primary and malignant hypertension. J Clin Invest. 1960 Jul;39:1091–1106. doi: 10.1172/JCI104124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Laragh J. H., Cannon P. J., Bentzel C. J., Sicinski A. M., Meltzer J. I. ANGIOTENSIN II, NOREPINEPHRINE, AND RENAL TRANSPORT OF ELECTROLYTES AND WATER IN NORMAL MAN AND IN CIRRHOSIS WITH ASCITES. J Clin Invest. 1963 Jul;42(7):1179–1192. doi: 10.1172/JCI104803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. MCQUEEN E. G., MORRISON R. B. The effects of synthetic angiotensin and noradrenaline on blood pressure and renal function. Br Heart J. 1961 Jan;23:1–6. doi: 10.1136/hrt.23.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. MULROW P. J., GANONG W. F. Stimulation of aldosterone secretion by angiotensisn. II. A preliminary report. Yale J Biol Med. 1961 Apr;33:386–395. [PMC free article] [PubMed] [Google Scholar]
  35. PEART W. S., BROWN J. J. Effect of angiotensin (hypertensin or angiotonin) on urine flow and electrolyte excretion in hypertensive patients. Lancet. 1961 Jan 7;1(7167):28–29. doi: 10.1016/s0140-6736(61)92191-2. [DOI] [PubMed] [Google Scholar]
  36. ROMANOFF L. P., MORRIS C. W., WELCH P., RODRIGUEZ R. M., PINCUS G. The metabolism of cortisol-4-C14 in young and elderly men. I. Secretion rate of cortisol and daily excretion of tetrahydrocortisol, allotetrahydrocortisol, tetrahydrocortisone and cortolone (20alpha and 20beta). J Clin Endocrinol Metab. 1961 Nov;21:1413–1425. doi: 10.1210/jcem-21-11-1413. [DOI] [PubMed] [Google Scholar]
  37. SEGEL N., HARRIS P., BISHOP J. M. The effects of synthetic hypertensin of the systemic and pulmonary circulations in man. Clin Sci. 1961 Feb;20:49–61. [PubMed] [Google Scholar]
  38. SELKURT E. E. Effect of pulse pressure and mean arterial pressure modification on renal hemodynamics and electrolyte and water excretion. Circulation. 1951 Oct;4(4):541–551. doi: 10.1161/01.cir.4.4.541. [DOI] [PubMed] [Google Scholar]
  39. TOBIAN L. Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol Rev. 1960 Apr;40:280–312. doi: 10.1152/physrev.1960.40.2.280. [DOI] [PubMed] [Google Scholar]
  40. URQUHART J., DAVIS J. O., HIGGINS J. T., Jr EFFECTS OF PROLONGED INFUSION OF ANGIOTENSIN II IN NORMAL DOGS. Am J Physiol. 1963 Dec;205:1241–1246. doi: 10.1152/ajplegacy.1963.205.6.1241. [DOI] [PubMed] [Google Scholar]
  41. VAAMONDE C. A., SPORN I. N., LANCESTREMERE R. G., BELSKY J. L., PAPPER S. AUGMENTED NATRIURETIC RESPONSE TO ACUTE SODIUM INFUSION AFTER BLOOD PRESSURE ELEVATION WITH METARAMINOL IN NORMOTENSIVE SUBJECTS. J Clin Invest. 1964 Mar;43:496–502. doi: 10.1172/JCI104935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. YU P. N., LURIA M. N., FINLAYSON J. K., STANFIELD C. A., CONSTANTINE H., FLATLEY F. J. The effects of angiotensin on pulmonary circulation and ventricular function. Circulation. 1961 Dec;24:1326–1337. doi: 10.1161/01.cir.24.6.1326. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES