Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1965 Sep;44(9):1523–1533. doi: 10.1172/JCI105259

IgG (7 S Gamma Globulin) Metabolism in Hypogammaglobulinemia: Studies in Patients with Defective Gamma Globulin Synthesis, Gastrointestinal Protein Loss, or Both*

Thomas A Waldmann 1,†, Paul J Schwab 1
PMCID: PMC292634  PMID: 14332165

Full text

PDF
1523

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN S. B., BJORNEBOE M. GAMMA GLOBULIN TURNOVER IN RABBITS BEFORE AND DURING HYPERIMMUNIZATION. J Exp Med. 1964 Apr 1;119:537–546. doi: 10.1084/jem.119.4.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ANDERSEN S. B. METABOLISM OF GAMMA-SS GLOBULIN IN SECONDARY HYPOGAMMAGLOBULINEMIA. Am J Med. 1963 Nov;35:708–714. doi: 10.1016/0002-9343(63)90141-4. [DOI] [PubMed] [Google Scholar]
  3. ARMSTRONG F. B., MARGEN S., TARVER H. Plasma protein. VII. Site of degradation of serum albumin. Proc Soc Exp Biol Med. 1960 Mar;103:592–596. doi: 10.3181/00379727-103-25606. [DOI] [PubMed] [Google Scholar]
  4. ASKONAS B. A., WHITE R. G. Sites of antibody production in the guinea-pig; the relation between in vitro synthesis of anti-ovalbumin and gamma-globulin and distribution of antibody-containing plasma cells. Br J Exp Pathol. 1956 Feb;37(1):61–74. [PMC free article] [PubMed] [Google Scholar]
  5. BARTH W. F., WOCHNER R. D., WALDMANN T. A., FAHEY J. L. METABOLISM OF HUMAN GAMMA MACROGLOBULINS. J Clin Invest. 1964 Jun;43:1036–1048. doi: 10.1172/JCI104987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BENNHOLD H., KALLEE E. Comparative studies on the half-life of I 131-labeled albumins and nonradioactive human serum albumin in a case of analbuminemia. J Clin Invest. 1959 May;38(5):863–872. doi: 10.1172/JCI103868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BERSON S. A., YALOW R. S., SCHREIBER S. S., POST J. Tracer experiments with I131 labeled human serum albumin: distribution and degradation studies. J Clin Invest. 1953 Aug;32(8):746–768. doi: 10.1172/JCI102789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. BLAINEY J. D., BREWER D. B., HARDWICKE J., SOOTHILL J. F. The nephrotic syndrome. Diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy. Q J Med. 1960 Apr;29:235–256. [PubMed] [Google Scholar]
  9. BRAMBELL F. W., HEMMINGS W. A., MORRIS I. G. A THEORETICAL MODEL OF GAMMA-GLOBULIN CATABOLISM. Nature. 1964 Sep 26;203:1352–1354. doi: 10.1038/2031352a0. [DOI] [PubMed] [Google Scholar]
  10. BRONSKY D., DUBIN A., KUSHNER D. S. The persistence in the blood of the radioactive label of albumins, gamma globulins, and globulins of intermediate mobility. VII. Uptake and die-away plots of S35 into serum albumins and gamma globulins after oral administration of labeled methionine in idiopathic hypogammaglobulinemia and multiple myeloma. J Lab Clin Med. 1959 May;53(5):665–679. [PubMed] [Google Scholar]
  11. BRUTON O. C., APT L., GITLIN D., JANEWAY C. A. Absence of serum gamma globulins. AMA Am J Dis Child. 1952 Nov;84(5):632–636. [PubMed] [Google Scholar]
  12. CATSOULIS E. A., FRANKLIN E. C., ORATZ M., ROTHSCHILD M. A. GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE. J Exp Med. 1964 Apr 1;119:615–631. doi: 10.1084/jem.119.4.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. COHEN S., FREEMAN T. Metabolic heterogeneity of human gamma-globulin. Biochem J. 1960 Sep;76:475–487. doi: 10.1042/bj0760475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. COHEN S., McGREGOR I. A., CARRINGTON S. Gamma-globulin and acquired immunity to human malaria. Nature. 1961 Nov 25;192:733–737. doi: 10.1038/192733a0. [DOI] [PubMed] [Google Scholar]
  15. COONS A. H., LEDUC E. H., CONNOLLY J. M. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J Exp Med. 1955 Jul 1;102(1):49–60. doi: 10.1084/jem.102.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. DAVIDSON J. D., WALDMANN T. A., GOODMAN D. S., GORDON R. S., Jr Protein-losing gastroenteropathy in congestive heart-failure. Lancet. 1961 Apr 29;1(7183):899–902. doi: 10.1016/s0140-6736(61)91768-8. [DOI] [PubMed] [Google Scholar]
  17. DIXON F. J., TALMAGE D. W., MAURER P. H., DEICHMILLER M. The half-life on homologous gamma globulin (antibody) in several species. J Exp Med. 1952 May;95(5):313–318. doi: 10.1084/jem.96.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. FAHEY J. L., HORBETT A. P. Human gamma globulin fractionation on anion exchange cellulose columns. J Biol Chem. 1959 Oct;234:2645–2651. [PubMed] [Google Scholar]
  19. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  20. FAHEY J. L., ROBINSON A. G. FACTORS CONTROLLING SERUM GAMMA-GLOBULIN CONCENTRATION. J Exp Med. 1963 Nov 1;118:845–868. doi: 10.1084/jem.118.5.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. GABUZDA T. G. The turnover and distribution of I-131-labeled myeloma and macroglobulin proteins. J Lab Clin Med. 1962 Jan;59:65–80. [PubMed] [Google Scholar]
  22. GITLIN D., JANEWAY C. A., FARR L. E. Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin. J Clin Invest. 1956 Jan;35(1):44–56. doi: 10.1172/JCI103251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. GORDON E. B., WIENER A. S. Studies on human serum gamma globulin. I. Half-life and rate of production. J Lab Clin Med. 1957 Feb;49(2):258–262. [PubMed] [Google Scholar]
  24. GORDON R. S., Jr Exudative enteropathy: abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinylpyrrolidone. Lancet. 1959 Feb 14;1(7068):325–326. doi: 10.1016/s0140-6736(59)90309-5. [DOI] [PubMed] [Google Scholar]
  25. HAVENS W. P., Jr, DICKENSHEETS J., BIERLY J. N., EBERHARD T. P. The half-life of I131 labeled normal human gamma globulin in patients with hepatic cirrhosis. J Immunol. 1954 Oct;73(4):256–258. [PubMed] [Google Scholar]
  26. HOLMAN H., NICKEL W. F., Jr, SLEISENGER M. H. Hypoproteinemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine. Am J Med. 1959 Dec;27:963–975. doi: 10.1016/0002-9343(59)90180-9. [DOI] [PubMed] [Google Scholar]
  27. Humphrey J. H., Fahey J. L. THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS. J Clin Invest. 1961 Sep;40(9):1696–1705. doi: 10.1172/JCI104392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. JENCKS W. P., JETTON M. R., DURRUM E. L. Paper electrophoresis as a quantitative method; serum proteins. Biochem J. 1955 Jun;60(2):205–215. doi: 10.1042/bj0600205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. LANG N., SCHETTLER G., WILDHACK R. Uber einen Fall von Agammaglobulinämie und das Verhalten parenteral zugefuhrten radioaktiv markierten Gammaglobulins im Serum. Klin Wochenschr. 1954 Sep 15;32(35-36):856–863. doi: 10.1007/BF01466837. [DOI] [PubMed] [Google Scholar]
  30. LIPPINCOTT S. W., KORMAN S., FONG C., STICKLEY E., WOLINS W., HUGHES W. L. Turnover of labeled normal gamma globulin in multiple myeloma. J Clin Invest. 1960 Apr;39:565–572. doi: 10.1172/JCI104069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. MARTIN C. M., GORDON R. S., FELTS W. R., MCCULLOUGH N. B. Studies on gamma globulin. I. Distribution and metabolism of antibodies and gamma globulin in hypogammaglobulinemic patients. J Lab Clin Med. 1957 Apr;49(4):607–616. [PubMed] [Google Scholar]
  32. McFARLANE A. S. Efficient trace-labelling of proteins with iodine. Nature. 1958 Jul 5;182(4627):53–53. doi: 10.1038/182053a0. [DOI] [PubMed] [Google Scholar]
  33. NOSSAL G. J. Antibody production by single cells. Br J Exp Pathol. 1958 Oct;39(5):544–551. [PMC free article] [PubMed] [Google Scholar]
  34. OWEN C. A., Jr, MCKENZIE B. F., HUIZENGA K. A. Turnover of gamma globulin in a patient with agammaglobulinemia as measured by radioiodinated human gamma globulin. J Appl Physiol. 1956 May;8(6):654–658. doi: 10.1152/jappl.1956.8.6.654. [DOI] [PubMed] [Google Scholar]
  35. PEARSON J. D., VEALL N., VETTER H. A practical method for plasma albumin turnover studies. Strahlentherapie. 1958;107(SONDERBD):290–297. [PubMed] [Google Scholar]
  36. RAUSEN A. R., CRUCHAUD A., McMILLAN C. W., GITLIN D. A study of fibrinogen turnover in classical hemophilia and congenital afibrinogenemia. Blood. 1961 Dec;18:710–716. [PubMed] [Google Scholar]
  37. SELL S. EVIDENCE FOR SPECIES' DIFFERENCES IN THE EFFECT OF SERUM GAMMA-GLOBULIN CONCENTRATION ON GAMMA-GLOBULIN CATABOLISM. J Exp Med. 1964 Nov 1;120:967–986. doi: 10.1084/jem.120.5.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. SELL S., FAHEY J. L. RELATIONSHIP BETWEEN GAMMA-GLOBULIN METABOLISM AND LOW SERUM GAMMA-GLOBULIN IN GERMFREE MICE. J Immunol. 1964 Jul;93:81–87. [PubMed] [Google Scholar]
  39. SELTZER G., BARON S., TOPOREK M. Idiopathic hypogammaglobulinemia and agammaglobulinemia; review of the literature and report of a case. N Engl J Med. 1955 Feb 17;252(7):252–255. doi: 10.1056/NEJM195502172520702. [DOI] [PubMed] [Google Scholar]
  40. SOLOMON A., WALDMANN T. A., FAHEY J. L. Clinical and experimental metabolism of normal 6.6s gamma-globulin in normal subjects and in patients with macroglobulinemia and multiple myeloma. J Lab Clin Med. 1963 Jul;62:1–17. [PubMed] [Google Scholar]
  41. SQUIRE J. R. Hypogammaglobulinaemia in the United Kingdom, 1956-61. Proc R Soc Med. 1962 May;55:393–395. [PubMed] [Google Scholar]
  42. STEINFELD J. L., WALDMANN T., DELEA C. S. Metabolism of infused serum albumin in the hypoproteinemia of gastro-intestinal protein loss and in analbuminemia. Trans Assoc Am Physicians. 1961;74:180–194. [PubMed] [Google Scholar]
  43. Sternlieb I., Morell A. G., Tucker W. D., Greene M. W., Scheinberg I. H. THE INCORPORATION OF COPPER INTO CERULOPLASMIN IN VIVO: STUDIES WITH COPPER AND COPPER. J Clin Invest. 1961 Oct;40(10):1834–1840. doi: 10.1172/JCI104407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. VESIN P., TROUPEL S., ACAR J., RENAULT H., DESBUQUOIS G., CATTAN R. [Enteropathy with protein loss and steatorrhea. Study using polyvinylpyrrolidone-I 131 and triolein-I 131. Effects of a gluten-free diet]. Bull Mem Soc Med Hop Paris. 1960 Feb 19;76:261–271. [PubMed] [Google Scholar]
  45. WALDMANN T. A., GORDON R. S., Jr, ROSSE W. STUDIES ON THE METABOLISM OF THE SERUM PROTEINS AND LIPIDS IN A PATIENT WITH ANALBUMINEMIA. Am J Med. 1964 Dec;37:960–968. doi: 10.1016/0002-9343(64)90136-6. [DOI] [PubMed] [Google Scholar]
  46. WALDMANN T. A. Gastrointestinal protein loss demonstrated by Cr-51-labelled albumin. Lancet. 1961 Jul 15;2(7194):121–123. doi: 10.1016/s0140-6736(61)92646-0. [DOI] [PubMed] [Google Scholar]
  47. WALDMANN T. A., LASTER L. ABNORMALITIES OF ALBUMIN METABOLISM IN PATIENTS WITH HYPOGAMMAGLOBULINEMIA. J Clin Invest. 1964 Jun;43:1025–1035. doi: 10.1172/JCI104986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. WALDMANN T. A., STEINFELD J. L., DUTCHER T. F., DAVIDSON J. D., GORDON R. S., Jr The role of the gastrointestinal system in "idiopathic hypoproteinemia". Gastroenterology. 1961 Sep;41:197–207. [PubMed] [Google Scholar]
  49. WETTERFORS J., GULLBERG R., LILJEDAHL S. O., PLANTIN L. O., BIRKE G., OLHAGEN B. Role of the stomach and small intestine in albumin breakdown. Acta Med Scand. 1960 Nov 25;168:347–363. doi: 10.1111/j.0954-6820.1960.tb13456.x. [DOI] [PubMed] [Google Scholar]
  50. YOUNG I. I., WOLFSON W. Q., COHN C. Studies in serum proteins; agammaglobulinemia in the adult. Am J Med. 1955 Aug;19(2):222–230. doi: 10.1016/0002-9343(55)90376-4. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES