Table 5.
Risk of mortality from coronary heart disease according to migraine status in men and women in Reykjavik Study (n=18 725*). Figures are age and multivariable† adjusted hazard ratios (95% confidence intervals)
| No headache | Non-migraine headache‡ | Migraine | Migraine without aura§ | Migraine with aura¶ | |
|---|---|---|---|---|---|
| Men | |||||
| Died/total | 1473/7068 | 275/1405 | 136/571 | 26/128 | 110/443 |
| Age adjusted | 1.00 | 0.99 (0.87 to 1.12) | 1.29 (1.08 to 1.54)** | 1.03 (0.70 to 1.52) | 1.38 (1.13 to 1.67)** |
| Multivariable adjusted | 1.00 | 0.96 (0.85 to 1.10) | 1.36 (1.14 to 1.62)** | 1.12 (0.76 to 1.65) | 1.43 (1.18 to 1.74)** |
| Women | |||||
| Died/total | 590/6003 | 213/2226 | 123/1452 | 35/498 | 88/954 |
| Age adjusted | 1.00 | 1.13 (0.96 to 1.32) | 1.13 (0.93 to 1.37) | 0.98 (0.69 to 1.38) | 1.20 (0.96 to 1.51) |
| Multivariable adjusted | 1.00 | 1.14 (0.98 to 1.34) | 1.13 (0.93 to 1.37) | 1.03 (0.73 to 1.46) | 1.17 (0.93 to 1.47) |
| Men and women | |||||
| Died/total | 2063/13 071 | 488/3631 | 259/2023 | 61/626 | 198/1397 |
| Age-sex adjusted | 1.00 | 1.04 (0.94 to 1.14) | 1.19 (1.04 to 1.35)** | 0.97 (0.75 to 1.25) | 1.28 (1.10 to 1.48)** |
| Multivariable adjusted | 1.00 | 1.03 (0.94 to 1.14) | 1.22 (1.07 to 1.39)** | 1.05 (0.82 to 1.37) | 1.28 (1.11 to 1.49)** |
*Of original 18 903 participants, 68 (0.36%) were lost to follow-up and 110 (0.58%) had missing data on blood pressure, cholesterol concentration, or BMI, leaving n=18 725 with 470 990 years of follow-up.
†Age, BMI, smoking (no, current, previous), education (primary, secondary, college/university), systolic and diastolic blood pressure, and use of antihypertensive drugs.
‡Headache without or with one symptom of migraine once or more a month.
§2-3 of unilateral, photophobia, nausea symptoms.
¶Migraine with visual or sensory symptoms, or both. Participants with symptoms of migraine without aura and migraine with aura were classified as migraine with aura.
**Significant at P<0.05.