Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1966 Jun;45(6):939–949. doi: 10.1172/JCI105409

The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin.

R R Cavalieri, G L Searle
PMCID: PMC292773  PMID: 4958064

Full text

PDF
939

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERT A., KEATING F. R., Jr Metabolic studies with I131 labeled thyroid compounds; comparison of the distribution and fate of radioactive d-1-thyroxine after oral and intravenous administration in the human. J Clin Endocrinol Metab. 1949 Dec;9(12):1406–1421. doi: 10.1210/jcem-9-12-1406. [DOI] [PubMed] [Google Scholar]
  2. ALBERT A., KEATING F. R., Jr The role of the gastrointestinal tract, including the liver, in the metabolism of radiothyroxine. Endocrinology. 1952 Nov;51(5):427–443. doi: 10.1210/endo-51-5-427. [DOI] [PubMed] [Google Scholar]
  3. BEISEL W. R., ZAINAL H., HANE S., DIRAIMONDO V. C., FORSHAM P. H. Low thyroidal iodine uptake with euthyroidism associated with deficient thyroid-binding globulin but normal cortisol binding. J Clin Endocrinol Metab. 1962 Dec;22:1165–1170. doi: 10.1210/jcem-22-12-1165. [DOI] [PubMed] [Google Scholar]
  4. BENUA R. S., ALBERT A., KEATING F. R., Jr The metabolism of radiothyroxine in exophthalmic goiter. J Clin Endocrinol Metab. 1952 Nov;12(11):1461–1473. doi: 10.1210/jcem-12-11-1461. [DOI] [PubMed] [Google Scholar]
  5. BERSON S. A., YALOW R. S., SCHREIBER S. S., POST J. Tracer experiments with I131 labeled human serum albumin: distribution and degradation studies. J Clin Invest. 1953 Aug;32(8):746–768. doi: 10.1172/JCI102789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BERSON S. A., YALOW R. S. The iodide trapping and binding functions of the thyroid. J Clin Invest. 1955 Feb;34(2):186–204. doi: 10.1172/JCI103072. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BLOMSTEDT B., PLANTIN L. O. THE EXTRATHYROIDAL DISTRIBUTION OF 131-I THYROXINE. Acta Endocrinol (Copenh) 1965 Apr;48:536–546. doi: 10.1530/acta.0.0480536. [DOI] [PubMed] [Google Scholar]
  8. Brown-Grant K., Tata J. R. The distribution and metabolism of thyroxine and 3:5:3'-triiodothyronine in the rabbit. J Physiol. 1961 Jun;157(1):157–176. doi: 10.1113/jphysiol.1961.sp006712. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CARR E. A., Jr, RIGGS D. S. Protein-bound iodine in extrathyroidal tissues. Biochem J. 1953 May;54(2):217–225. doi: 10.1042/bj0540217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. CAVALIERI R. R. Hyperthyroidism and decreased thyroxine binding by serum proteins. J Clin Endocrinol Metab. 1961 Nov;21:1455–1468. doi: 10.1210/jcem-21-11-1455. [DOI] [PubMed] [Google Scholar]
  11. CHRISTENSEN L. K. Thyroxine-releasing effect of salicylate and of 2,4-dinitrophenol. Nature. 1959 Apr 25;183(4669):1189–1190. doi: 10.1038/1831189a0. [DOI] [PubMed] [Google Scholar]
  12. FRIIS T. Thyroxine metabolism in man estimated by means of I 131-labelled L-thyroxine. Acta Endocrinol (Copenh) 1958 Dec;29(4):587–601. doi: 10.1530/acta.0.0290587. [DOI] [PubMed] [Google Scholar]
  13. Flock E. V., Owen C. A., Jr Effect of salicylate on the metabolism of L-thyroxine. Endocrinology. 1965 Sep;77(3):475–484. doi: 10.1210/endo-77-3-475. [DOI] [PubMed] [Google Scholar]
  14. GREGERMAN R. I., GAFFNEY G. W., SHOCK N. W., CROWDER S. E. Thyroxine turnover in euthyroid man with special reference to changes with age. J Clin Invest. 1962 Nov;41:2065–2074. doi: 10.1172/JCI104664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. HADDAD H. M. Rates of I 131-labeled thyroxine metabolism in euthyroid children. J Clin Invest. 1960 Oct;39:1590–1594. doi: 10.1172/JCI104181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. INGBAR S. H., FREINKEL N. Regulation of the peripheral metabolism of the thyroid hormones. Recent Prog Horm Res. 1960;16:353–403. [PubMed] [Google Scholar]
  17. Ingbar S. H. CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE-BINDING GLOBULIN OF PLASMA. J Clin Invest. 1961 Nov;40(11):2053–2063. doi: 10.1172/JCI104431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. LEE N. D., HENRY R. J., GOLUB O. J. DETERMINATION OF THE FREE THYROXINE CONTENT OF SERUM. J Clin Endocrinol Metab. 1964 Jun;24:486–495. doi: 10.1210/jcem-24-6-486. [DOI] [PubMed] [Google Scholar]
  19. LENNON E. J., ENGBRING N. H., ENGSTROM W. W. Studies of the rate of disappearance of labeled thyroxine from the intravascular compartment. J Clin Invest. 1961 Jun;40:996–1005. doi: 10.1172/JCI104339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MYANT N. B. Biliary excretion of thyroxine in humans. Clin Sci. 1956 May;15(2):227–237. [PubMed] [Google Scholar]
  21. NICOLOFF J. T., DOWLING J. T., PATTON D. D. INHERITANCE OF DECREASED THYROXINE-BINDING BY THE THYROXINE-BINDING GLOBULIN. J Clin Endocrinol Metab. 1964 Mar;24:294–298. doi: 10.1210/jcem-24-3-294. [DOI] [PubMed] [Google Scholar]
  22. OPPEHNEIMER J. H., SURKS M. I., BERNSTEIN G., SMITY J. C. METABOLISM OF IODINE-131--LABELED THYROXINE-BINDING PREALBUMIN IN MAN. Science. 1965 Aug 13;149(3685):748–750. doi: 10.1126/science.149.3685.748. [DOI] [PubMed] [Google Scholar]
  23. OPPENHEIMER J. H., SQUEF R., SURKS M. I., HAUER H. BINDING OF THYROXINE BY SERUM PROTEINS EVALUATED BY EQUILIBRUM DIALYSIS AND ELECTROPHORETIC TECHNIQUES. ALTERATIONS IN NONTHYROIDAL ILLNESS. J Clin Invest. 1963 Nov;42:1769–1782. doi: 10.1172/JCI104862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Oddie T. H., Fisher D. A., Epperson D. Effect of exogenous thyroxine on thyroid accumulation and secretion in euthyroid subjects. J Clin Endocrinol Metab. 1965 Sep;25(9):1196–1206. doi: 10.1210/jcem-25-9-1196. [DOI] [PubMed] [Google Scholar]
  25. PILEGGI V. J., LEE N. D., GOLUB O. J., HENRY R. J. Determination of iodine compounds in serum. I. Serum thyroxine in the presence of some iodine contaminants. J Clin Endocrinol Metab. 1961 Oct;21:1272–1279. doi: 10.1210/jcem-21-10-1272. [DOI] [PubMed] [Google Scholar]
  26. ROBBINS J., RALL J. E. Proteins associated with the thyroid hormones. Physiol Rev. 1960 Jul;40:415–489. doi: 10.1152/physrev.1960.40.3.415. [DOI] [PubMed] [Google Scholar]
  27. ROBBINS J. Reverse-flow zone electrophoresis; a method for determining the thyroxine-binding capacity of serum protein. Arch Biochem Biophys. 1956 Aug;63(2):461–469. doi: 10.1016/0003-9861(56)90062-5. [DOI] [PubMed] [Google Scholar]
  28. SURKS M. I., OPPENHEIMER J. H. POSTOPERATIVE CHANGES IN THE CONCENTRATION OF THYROXINE-BINDING PREALBUMIN AND SERUM FREE THYROXINE. J Clin Endocrinol Metab. 1964 Aug;24:794–802. doi: 10.1210/jcem-24-8-794. [DOI] [PubMed] [Google Scholar]
  29. Socolow E. L., Woeber K. A., Purdy R. H., Holloway M. T., Ingbar S. H. Preparation of I-131-labeled human serum prealbumin and its metabolism in normal and sick patients. J Clin Invest. 1965 Oct;44(10):1600–1609. doi: 10.1172/JCI105266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. TANAKA S., STARR P. A euthyroid man without thyroxine-binding globulin. J Clin Endocrinol Metab. 1959 Apr;19(4):485–487. doi: 10.1210/jcem-19-4-485. [DOI] [PubMed] [Google Scholar]
  31. WOLFF J., STANDAERT M. E., RALL J. E. Thyroxine displacement from serum proteins and depression of serum protein-bound iodine by certain drugs. J Clin Invest. 1961 Aug;40:1373–1379. doi: 10.1172/JCI104368. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES