TABLE 2.
Substrate kinetics
| Fed | Fasted | |
|---|---|---|
| Rd Glucose (μmol/kg/min) | ||
| Basal | 11.3 ± 0.6 | 7.6 ± 0.4* |
| Clamp | 38.0 ± 2.8 | 18.8 ± 0.9* |
| Delta | 26.7 ± 2.6 | 11.2 ± 1.0* |
| EGP (μmol/kg/min) | ||
| Basal | 10.7 ± 0.6 | 6.8 ± 0.3* |
| Clamp | −1.0 ± 0.4 | 0.7 ± 0.4* |
| Delta absolute | −11.7 ± 0.6 | −6.07 ± 0.5* |
| Delta % | 111.6 ± 5.9 | 90.0 ± 6.7* |
| CHO oxidation (μmol/kg/min) | ||
| Basal | 9.7 ± 0.8 | 3.4 ± 0.6* |
| Clamp | 20.8 ± 1.1 | 6.6 ± 0.8* |
| Delta | 11.1 ± 0.9 | 3.4 ± 0.7* |
| NOGD (μmol/kg/min) | ||
| Basal | 1.6 ± 0.5 | 4.2 ± 0.8* |
| Clamp | 17.2 ± 2.2 | 12.6 ± 0.8* |
| Delta | 15.6 ± 2.4 | 8.2 ± 1.1* |
| Lipid oxidation (μmol/kg/min) | ||
| Basal | 1.2 ± 0.0 | 1.8 ± 0.2* |
| Clamp | 0.3 ± 0.1 | 1.52 ± 0.1* |
| Delta | −0.8 ± 0.1 | −0.31 ± 0.1* |
Values are mean ± SE.
*P < 0.05. EGP, endogenous glucose production; CHO, carbohydrate; NOGD, nonoxidative glucose disposal.