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. 1967 Dec;46(12):2053–2063. doi: 10.1172/JCI105693

Uneven Distribution of Maternal and Fetal Placental Blood Flow, as Demonstrated Using Macroaggregates, and Its Response to Hypoxia*

Gordon G Power 1,2,3,4,5,‡, Lawrence D Longo 1,2,3,4,5,§, Henry N Wagner Jr 1,2,3,4,5, David E Kuhl 1,2,3,4,5,ǁ, Robert E Forster II 1,2,3,4,5
PMCID: PMC292956  PMID: 6074007

Abstract

A technique is described for studying the distribution of blood flow to the maternal and fetal placental vessels in sheep and dogs with radioactive labeled macroaggregates of albumin.

When the maternal animal breathed room air the distribution of maternal placental blood flow was uneven among the cotyledons as well as within a given cotyledon. Fetal blood flow was also distributed nonuniformly among and within the cotyledons. The relation of maternal to fetal placental blood flow was also markedly uneven (coefficient of correlation, τ = 0.066). After the animal was made hypoxic by breathing 10-12% O2 the distribution of maternal, fetal, and maternal/fetal placental flows became more uniform. The coefficient of correlation of maternal to fetal flow was high (τ = 0.53, P < 0.01). While the maternal animal breathed room air, after ligation of a major branch of the umbilical artery the distribution of maternal, fetal, and maternal/fetal flows in the remaining two-thirds to three-fourths of the placenta became more uniform. The correlation coefficient for maternal to fetal flow was high (τ = 0.35, P < 0.01).

It appears that under normal circumstances with uneven distribution of blood flows there is a considerable portion of the placenta that does not receive blood flow in optimum quantities to promote efficient O2 exchange. Failure to consider the influence of nonuniform maternal flow/fetal flow will result in overestimation of mean maternal-fetal oxygen tension gradients, and thus underestimation of the placental diffusing capacity for oxygen.

In response to maternal hypoxia or compromise of the fetal placental circulation the distribution of maternal, fetal, and maternal/fetal flows becomes more uniform, thereby increasing the efficiency of placental O2 exchange.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brosens I., Dixon H. G. The anatomy of the maternal side of the placenta. J Obstet Gynaecol Br Commonw. 1966 Jun;73(3):357–363. doi: 10.1111/j.1471-0528.1966.tb05175.x. [DOI] [PubMed] [Google Scholar]
  2. Faber J. J., Hart F. M. The rabbit placenta as an organ of diffusional exchange. Comparison with other species by dimensional analysis. Circ Res. 1966 Oct;19(4):816–833. doi: 10.1161/01.res.19.4.816. [DOI] [PubMed] [Google Scholar]
  3. KAISER I. H., CUMMINGS J. N., REYNOLDS S. R., MARBARGER J. P. Acclimatization response of the pregnant ewe and fetal lamb to diminished ambient pressure. J Appl Physiol. 1958 Sep;13(2):171–178. doi: 10.1152/jappl.1958.13.2.171. [DOI] [PubMed] [Google Scholar]
  4. Longo L. D., Power G. G., Forster R. E., 2nd Respiratory function of the placenta as determined with carbon monoxide in sheep and dogs. J Clin Invest. 1967 May;46(5):812–828. doi: 10.1172/JCI105581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lucas W., Kirschbaum T., Assali N. S. Spinal shock and fetal oxygenation. Am J Obstet Gynecol. 1965 Oct 15;93(4):583–587. doi: 10.1016/0002-9378(65)90520-x. [DOI] [PubMed] [Google Scholar]
  6. METCALFE J., MESCHIA G., HELLEGERS A., PRYSTOWSKY H., HUCKABEE W., BARRON D. H. Observations on the placental exchange of the respiratory gases in pregnant ewes at high altitude. Q J Exp Physiol Cogn Med Sci. 1962 Jan;47:74–92. doi: 10.1113/expphysiol.1962.sp001578. [DOI] [PubMed] [Google Scholar]
  7. METCALFE J., MOLL W., BARTELS H., HILPERT P., PARER J. T. TRANSFER OF CARBON MONOXIDE AND NITROUS OXIDE IN THE ARTIFICIALLY PERFUSED SHEEP PLACENTA. Circ Res. 1965 Feb;16:95–101. doi: 10.1161/01.res.16.2.95. [DOI] [PubMed] [Google Scholar]
  8. Martin C. B., Jr, Ramsey E. M., Donner M. W. The fetal placental circulation in rhesus monkeys demonstrated by radioangiography. Am J Obstet Gynecol. 1966 Aug 1;95(7):943–947. doi: 10.1016/0002-9378(66)90542-4. [DOI] [PubMed] [Google Scholar]
  9. NICOLL P. A., WEBB R. L. Vascular patterns and active vasomotion as determiners of flow through minute vessels. Angiology. 1955 Aug;6(4):291–308. doi: 10.1177/000331975500600403. [DOI] [PubMed] [Google Scholar]
  10. RAMSEY E. M., CORNER G. W., Jr, DONNER M. W. Serial and cineradioangiographic visualization of maternal circulation in the primate (hemochorial) placenta. Am J Obstet Gynecol. 1963 May 15;86:213–225. doi: 10.1016/0002-9378(63)90434-4. [DOI] [PubMed] [Google Scholar]
  11. TAPLIN G. V., JOHNSON D. E., DORE E. K., KAPLAN H. S. SUSPENSIONS OF RADIOALBUMIN AGGREGATES FOR PHOTOSCANNING THE LIVER, SPLEEN, LUNG AND OTHER ORGANS. J Nucl Med. 1964 Apr;5:259–275. [PubMed] [Google Scholar]

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