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. 1958 Jan;37(1):70–86. doi: 10.1172/JCI103587

CORRECTION OF DEFECTS IN CLOTTING ACCELERATOR ACTIVITY BY ADMINISTRATION OF METHIONINE AND VITAMIN K AND OF A NEW SULFHYDRYL-SUBSTITUTED METHYLNAPHTHOQUINONE, VITAMIN K-S(II)1,2

John R Carter 1, E D Warner 1
PMCID: PMC293059  PMID: 13491715

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albanese A. A. PREPARATION OF METHIONINE AND TRYPTOPHANE-FREE CASEIN HYDROLYSATES. Science. 1943 Jul 9;98(2532):46–46. doi: 10.1126/science.98.2532.46. [DOI] [PubMed] [Google Scholar]
  2. BINKLEY F. A note on the specificity of the enzymatic cleavage of thioethers. J Biol Chem. 1951 Sep;192(1):209–211. [PubMed] [Google Scholar]
  3. CARTER J. R., WARNER E. D. Accelerator-globulin and prothrombin preparation of accelerator-globulin free plasma. Proc Soc Exp Biol Med. 1950 May;74(1):30–32. doi: 10.3181/00379727-74-17799. [DOI] [PubMed] [Google Scholar]
  4. CARTER J. R., WARNER E. D. Concept of a common protein moiety, containing disulfide bonds, in prothrombin, prothrombin derivative (autoprothrombin) and thrombin. Am J Physiol. 1956 Jan;184(1):195–201. doi: 10.1152/ajplegacy.1955.184.1.195. [DOI] [PubMed] [Google Scholar]
  5. CARTER J. R., WARNER E. D. Evaluation of disulfide bonds and sulfhydryl groups in the blood clotting mechanism. Am J Physiol. 1954 Dec;179(3):549–556. doi: 10.1152/ajplegacy.1954.179.3.549. [DOI] [PubMed] [Google Scholar]
  6. CARTER J. R., WARNER E. D. Importance of the disulfide (-S-S-) linkage in the blood-clotting mechanism. Am J Physiol. 1953 Apr;173(1):109–114. doi: 10.1152/ajplegacy.1953.173.1.109. [DOI] [PubMed] [Google Scholar]
  7. CARTER J. R., WARNER E. D. Quantitative estimation of plasma accelerator-globulin. Proc Soc Exp Biol Med. 1950 Oct;75(1):223–226. doi: 10.3181/00379727-75-18152. [DOI] [PubMed] [Google Scholar]
  8. DEGOWIN E. L., SHEETS R. F., HAMILTON H. E., CARTER J. R. Deficit of prothrombin and accelerator globulin in man from prolonged excessive feeding of methionine. Trans Assoc Am Physicians. 1955;68:118–125. [PubMed] [Google Scholar]
  9. DRESKIN O. H., ROSENTHAL N. A hemophilia-like disease with prolonged coagulation time and a circulating anticoagulant; report of a case in a female. Blood. 1950 Jan;5(1):46–60. [PubMed] [Google Scholar]
  10. FERGUSON J. H., PATCH M. J. Determinants of the so-called prothrombin time. Proc Soc Exp Biol Med. 1956 Nov;93(2):193–196. doi: 10.3181/00379727-93-22705. [DOI] [PubMed] [Google Scholar]
  11. FRICK P. G. Acquired circulating anticoagulants in systemic collagen disease; auto-immune thromboplastin deficiency. Blood. 1955 Jul;10(7):691–706. [PubMed] [Google Scholar]
  12. GIBSON R. B., CARR T. L., GREEN S., FOWLER W. M. Photometric assay of plasma heparin. Proc Soc Exp Biol Med. 1952 Apr;79(4):577–580. doi: 10.3181/00379727-79-19452. [DOI] [PubMed] [Google Scholar]
  13. HILL J. M., SPEER R. J., ROBERTS A., MALONEY M. Hypoprothrombinemia and hypoproconvertinemia during pregnancy. J Lab Clin Med. 1955 Feb;45(2):308–312. [PubMed] [Google Scholar]
  14. HORDER M. H. Isolierter Factor V-Mangel bedingt durch einen spezifischen Hemmkörper. Acta Haematol. 1955 Apr;13(4):235–241. doi: 10.1159/000204943. [DOI] [PubMed] [Google Scholar]
  15. KISLIUK R. L., PATWARDHAN M. V., SAKAMI W. The metabolism of the methionine carbon chain in the intact rat. J Biol Chem. 1956 Aug;221(2):885–893. [PubMed] [Google Scholar]
  16. KOHL H. Uber die Einwirkung oral verabreichter Aminosäuren auf die Prothrombinzeit und die Thrombocytenzahl gerinnungsgesunder Probanden. Dtsch Z Verdau Stoffwechselkr. 1950 Sep;10(5):185–192. [PubMed] [Google Scholar]
  17. KOPPEL J. L., MUELLER D., OLWIN J. H. Nature of the inhibition of thrombin formation by sulfhydryl-oxidizing agents. Am J Physiol. 1956 Sep;187(1):113–121. doi: 10.1152/ajplegacy.1956.187.1.113. [DOI] [PubMed] [Google Scholar]
  18. KOPPEL J. L., MUELLER D., OLWIN J. H. Observations on role of free sulfhydryl groups in prothrombin activation. Proc Soc Exp Biol Med. 1955 Aug;89(4):514–520. doi: 10.3181/00379727-89-21862. [DOI] [PubMed] [Google Scholar]
  19. LAKI K., KOMINZ D. R., SYMONDS P., LORAND L., SEEGERS W. H. The amino acid composition of bovine prothrombin. Arch Biochem Biophys. 1954 Apr;49(2):276–282. doi: 10.1016/0003-9861(54)90198-8. [DOI] [PubMed] [Google Scholar]
  20. LEE S. L., SANDERS M. A disorder of blood coagulation in systemic lupus erythematosus. J Clin Invest. 1955 Dec;34(12):1814–1822. doi: 10.1172/JCI103237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LEWIS M. L., WARE A. G. The mechanism of action of human accelerator globulin and its relation to other clotting factors. Blood. 1954 May;9(5):520–530. [PubMed] [Google Scholar]
  22. OLWIN J. H. Human plasma as a source of prothrombin in the Ac-globulin assay. Proc Soc Exp Biol Med. 1950 Nov;75(2):313–315. doi: 10.3181/00379727-75-18183. [DOI] [PubMed] [Google Scholar]
  23. OWREN P. A. Prothrombin and accessory factors; clinical significance. Am J Med. 1953 Feb;14(2):201–215. doi: 10.1016/0002-9343(53)90019-9. [DOI] [PubMed] [Google Scholar]
  24. POOL J. G., SPAET T. H. Ethionine-induced depression of plasma antihemophilic globulin in the rat. Proc Soc Exp Biol Med. 1954 Oct;87(1):54–57. doi: 10.3181/00379727-87-21283. [DOI] [PubMed] [Google Scholar]
  25. QUICK A. J., COLLENTINE G. E. Role of vitamin K in the synthesis of prothrombin. Am J Physiol. 1951 Mar;164(3):716–721. doi: 10.1152/ajplegacy.1951.164.3.716. [DOI] [PubMed] [Google Scholar]
  26. SEEGERS W. H., ALKJAERSIG N., JOHNSON S. A. Formation of autoprothrombin in solutions containing purified prothrombin and purified platelet factor 3. Am J Physiol. 1955 Jun;181(3):589–594. doi: 10.1152/ajplegacy.1955.181.3.589. [DOI] [PubMed] [Google Scholar]
  27. SETNA S. S., ALTMAN S. J. Unusual bleeding during pregnancy: report of a case due to hypoprothrombinemia and hypoproconvertinemia. Blood. 1956 May;11(5):430–435. [PubMed] [Google Scholar]
  28. WITTE S., HEINKEL K., HENNING N., DIRNBERGER P. Das Verhalten der Blutgerinnungsfaktoren während der Athioninpankreatitis der Ratte. Z Gesamte Exp Med. 1953;121(3):228–238. [PubMed] [Google Scholar]

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