Figure 1.

Level of genomic complexity and size distribution of copy-number aberrations. The columns represent IGHV4-34 samples; subset #4 (n=17), subset #16 (n=8) and non-subset #4/16 (n=34); IGHV3-21 samples; subset #2 (n=29) and non-subset #2 (n=13) and a ‘general’ CLL cohort (n=203) from the study by Gunnarsson et al.²³ Samples from the current study that overlapped with our recent array-based Swedish CLL cohort study²³ were not removed from analysis, as the overlap between studies was limited. (A) Level of genomic complexity in each group is based on the frequency of samples that carry a certain number of CNAs (0, 1, 2 or ≥3). (B) The size distribution of copy-number aberrations (<1 Mbp, 1–5 Mbp or >5 Mbp) is shown as the frequency of the total number of copy-number aberrations. Note that subset #4 samples do not carry copy-number aberrations greater than 5 Mbp, whereas the non-subset #2 samples show the highest frequency of copy-number aberrations greater than 5 Mbp.