Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1958 May;37(5):631–639. doi: 10.1172/JCI103646

THE PHYSIOLOGIC SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION. I. COMPARISON OF THE EFFECTS OF GLUCAGON-FREE INSULIN ADMINISTERED VIA THE PORTAL VEIN AND VIA A PERIPHERAL VEIN ON THE MAGNITUDE OF HYPOGLYCEMIA AND PERIPHERAL GLUCOSE UTILIZATION1

Leonard L Madison 1,2, Roger H Unger 1,2
PMCID: PMC293132  PMID: 13539203

Full text

PDF
631

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BELL D. M., BURNS T. Effect on femoral A-V glucose difference of insulin injected into an antecubital vein and into a femoral artery. J Clin Invest. 1952 Jul;31(7):717–720. doi: 10.1172/JCI102654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CONN J. W., FAJANS S. S., HENNES A. R., WAJCHENBERG B. L. Comparative effects of insulin and orinase on blood levels of pyruvate and alpha-ketoglutarate in normal subjects. Metabolism. 1957 Jan;6(1):63–69. [PubMed] [Google Scholar]
  3. DUNN D. F., FRIEDMANN B., MAASS A. R., REICHARD G. A., WEINHOUSE S. Effects of insulin on blood glucose entry and removal rates in normal dogs. J Biol Chem. 1957 Mar;225(1):225–237. [PubMed] [Google Scholar]
  4. ELRICK H., HLAD C. J., Jr, ARAI Y., SMITH A. The interaction of glucagon and insulin on blood glucose. J Clin Invest. 1956 Jul;35(7):757–762. doi: 10.1172/JCI103327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. ELRICK H., HLAD C. J., Jr, WITTEN T. The enhancement of peripheral glucose utilization by glucagon. J Clin Invest. 1955 Dec;34(12):1830–1838. doi: 10.1172/JCI103239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FROESCH E. R., RENOLD A. E., THORN G. W., WINEGRAD A. I. Studies on the site of action of the arylsulfonylureas in man. Metabolism. 1956 Nov;5(6 Pt 2):757–767. [PubMed] [Google Scholar]
  7. HAUGAARD N., HAUGAARD E. S., STADIE W. C. Combination of insulin with cells. J Biol Chem. 1954 Nov;211(1):289–295. [PubMed] [Google Scholar]
  8. HENDERSON M. J., WRENSHALL G. A., ODENSE P. Effects of insulin on rates of glucose transfer in the depancreatized dog. Can J Biochem Physiol. 1955 Nov;33(6):926–939. [PubMed] [Google Scholar]
  9. LEE N. D., WILLIAMS R. H. The intracellular localization of labeled thyroxine and labeled insulin in mammalian liver. Endocrinology. 1954 Jan;54(1):5–19. doi: 10.1210/endo-54-1-5. [DOI] [PubMed] [Google Scholar]
  10. LEVINE R., FRITZ I. B. The relation of insulin to liver metabolism. Diabetes. 1956 May-Jun;5(3):209-19; discussion, 219-22. doi: 10.2337/diab.5.3.209. [DOI] [PubMed] [Google Scholar]
  11. MIRSKY I. A., PERISUTTI G. The inactivation of insulin by liver slices of the rat. Endocrinology. 1953 Jun;52(6):698–704. doi: 10.1210/endo-52-6-698. [DOI] [PubMed] [Google Scholar]
  12. SMOGYI M. Notes on sugar determination. J Biol Chem. 1952 Mar;195(1):19–23. [PubMed] [Google Scholar]
  13. STADIE W. C. Current concepts of the action of insulin. Physiol Rev. 1954 Jan;34(1):52–100. doi: 10.1152/physrev.1954.34.1.52. [DOI] [PubMed] [Google Scholar]
  14. STADIE W. C., HAUGAARD N., VAUGHAN M. The quantitative relation between insulin and its biological activity. J Biol Chem. 1953 Feb;200(2):745–751. [PubMed] [Google Scholar]
  15. WALL J. S., STEELE R., DE BODO R. C., ALTSZULER N. Effect of insulin on utilization and production of circulating glucose. Am J Physiol. 1957 Apr;189(1):43–50. doi: 10.1152/ajplegacy.1957.189.1.43. [DOI] [PubMed] [Google Scholar]
  16. WILLIAMS R. H. Insulin distribution and degradation. Metabolism. 1956 Mar;5(2):128–137. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES