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. 1960 Mar;39(3):523–533. doi: 10.1172/JCI104066

THE METABOLIC EFFECTS OF THE ACETIC AND PROPIONIC ACID ANALOGS OF THYROXINE AND TRIIODOTHYRONINE*

S Richardson Hill Jr 1,2, S B Barker 1,2, Jean H McNeil 1,2,†, John O Tingley 1,2,‡, Lester L Hibbett 1,2,†
PMCID: PMC293333  PMID: 13852407

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBRIGHT E. C., LARDY H. A., LARSON F. C., TOMITA K. Enzymatic conversion of thyroxine to tetraiodothyroacetic acid and of triiodothyronine to triiodothyroacetic acid. J Biol Chem. 1957 Jan;224(1):387–397. [PubMed] [Google Scholar]
  2. ALBRIGHT E. C., TOMITA K., LARSON F. C. In vitro metabolism of triiodothyronine. Endocrinology. 1959 Feb;64(2):208–214. doi: 10.1210/endo-64-2-208. [DOI] [PubMed] [Google Scholar]
  3. BARKER S. B., HUMPHREY M. J., SOLEY M. H. The clinical determination of protein-bound iodine. J Clin Invest. 1951 Jan;30(1):55–62. doi: 10.1172/JCI102416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BARKER S. B., LEWIS W. J. Metabolic actions of acetic acid analogs of thyroxine and triiodothyronine. Proc Soc Exp Biol Med. 1956 Apr;91(4):650–654. doi: 10.3181/00379727-91-22361. [DOI] [PubMed] [Google Scholar]
  5. BARKER S. B. Thyroid. Annu Rev Physiol. 1955;17:417–442. doi: 10.1146/annurev.ph.17.030155.002221. [DOI] [PubMed] [Google Scholar]
  6. BOYD G. S., OLIVER M. F. The effect on thyroxine analogues on lipid and lipoprotein metabolism. Bull Schweiz Akad Med Wiss. 1957 Apr;13(1-4):384–395. [PubMed] [Google Scholar]
  7. BOYD G. S., OLIVER M. F. The influence of triiodothyroacetic acid on the circulating lipids and lipoproteins in euthyroid men with coronary disease. Lancet. 1957 Jan 19;272(6960):124–125. doi: 10.1016/s0140-6736(57)90200-3. [DOI] [PubMed] [Google Scholar]
  8. BUNIM J. J., PECHET M. M., BOLLET A. J. Studies on metacortandralone and metacortandracin in rheumatoid arthritis; antirheumatic potency, metabolic effects, and hormonal properties. J Am Med Assoc. 1955 Jan 22;157(4):311–318. doi: 10.1001/jama.1955.02950210007003. [DOI] [PubMed] [Google Scholar]
  9. CHURCH G., LAWRIE T. D., PIRRIE R. The effect of trilodothyroacetic acid on serum cholesterol and phospholipids in patients with coronary artery diseases. Scott Med J. 1957 Jul;2(7):293–298. doi: 10.1177/003693305700200704. [DOI] [PubMed] [Google Scholar]
  10. DE GRAEFF J., QUERIDO A., WICHT C. L. Metabolic effects of intravenous triiodothyroacetic acid in primary myxedema. J Clin Endocrinol Metab. 1957 Feb;17(2):328–330. doi: 10.1210/jcem-17-2-328. [DOI] [PubMed] [Google Scholar]
  11. ETLING N., BARKER S. B. Metabolism of thyroxine during prolonged kidney cortex incubation. Endocrinology. 1959 May;64(5):753–765. doi: 10.1210/endo-64-5-753. [DOI] [PubMed] [Google Scholar]
  12. FRAWLEY T. F., MCCLINTOCK J. C., BEEBE R. T., MARTHY G. L. Metabolic and therapeutic effects of triiodothyronine. J Am Med Assoc. 1956 Feb 25;160(8):646–652. doi: 10.1001/jama.1956.02960430036007. [DOI] [PubMed] [Google Scholar]
  13. GOOLDEN A. W. The physiological activity of tetraiodothyroacetic acid. Lancet. 1956 Jun 9;270(6928):890–891. doi: 10.1016/s0140-6736(56)91348-4. [DOI] [PubMed] [Google Scholar]
  14. GROSS J., PITT-RIVERS R. 3:5:3' -triiodothyronine. 1. Isolation from thyroid gland and synthesis. Biochem J. 1953 Mar;53(4):645–650. doi: 10.1042/bj0530645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. GROSS J., PITT-RIVERS R. Physiological activity of 3:5:3'-L-triiodothyronine. Lancet. 1952 Mar 22;1(6708):593–594. doi: 10.1016/s0140-6736(52)90104-9. [DOI] [PubMed] [Google Scholar]
  16. GROSS J., PITT-RIVERS R., TROTTER W. R. Effect of 3:5:3'-L-triiodothyronine in myxoedema. Lancet. 1952 May 24;1(6717):1044–1045. doi: 10.1016/s0140-6736(52)90695-8. [DOI] [PubMed] [Google Scholar]
  17. HARINGTON C. R., PITT-RIVERS R. Note on the synthesis of the acetic acid analogue of thyroxine. Biochem J. 1952 Feb;50(4):438–439. doi: 10.1042/bj0500438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. JOUAN P., HAZARD C., PAILHERET J., BARRE F. Action de l'acide 3.5.3' triiodothyroacétique sur le taux du cholestérol sanguin. Ann Endocrinol (Paris) 1958 May-Jun;19(3):473–477. [PubMed] [Google Scholar]
  19. JOUAN P., MICHEL R., ROCHE J. Sur la présence d'acide 3:5:3'-triiodothyroacétique et de 3:3'-diiodothyronine dans le muscle aprés administration de L-3:5:3'-triiodothyronine au rat. Bull Soc Chim Biol (Paris) 1956 Sep 4;38(5-6):941–950. [PubMed] [Google Scholar]
  20. JOUAN P., MICHEL R., ROCHE J., WOLF W. The recovery of 3:5:3' -triiodothyroacetic acid and 3:3' -diiodothyronine from rat kidney after injection of 3:5:3' triiodothyronine. Endocrinology. 1956 Oct;59(4):425–432. doi: 10.1210/endo-59-4-425. [DOI] [PubMed] [Google Scholar]
  21. KYLE L. H., CANARY J. J., MEYER R. J., PAC F. P. Comparison of the metabolic effects of different thyroid preparation. J Clin Endocrinol Metab. 1958 Sep;18(9):950–965. doi: 10.1210/jcem-18-9-950. [DOI] [PubMed] [Google Scholar]
  22. LERMAN J., PITT-RIVERS R. Physiologic activity of triiodo-and tetraiodo-thyroacetic acid in human myxedema. J Clin Endocrinol Metab. 1956 Nov;16(11):1470–1479. doi: 10.1210/jcem-16-11-1470. [DOI] [PubMed] [Google Scholar]
  23. LERMAN J. The contribution of triiodothyronine to thyroid physiology. J Clin Endocrinol Metab. 1954 Jun;14(6):690–693. doi: 10.1210/jcem-14-6-690. [DOI] [PubMed] [Google Scholar]
  24. LIDDLE G. W. Studies of structure-function relationships of steroids. II. The 6 alpha-methylcorticosteroids. Metabolism. 1958 Jul;7(4 Pt 2):405–415. [PubMed] [Google Scholar]
  25. LIPSETT M. B., PEARSON O. H., RALL J. E., RAWSON R. W. Metabolic effects in man of the acetic-acid analogues of thyroxine and triiodothyronine. J Clin Endocrinol Metab. 1956 Oct;16(10):1299–1310. doi: 10.1210/jcem-16-10-1299. [DOI] [PubMed] [Google Scholar]
  26. MACKAY I. R., GOBLE A. J., SPARKES F. The effect of triiodothyroacetate (triac) in hypercholesterolaemia. Med J Aust. 1957 Apr 27;44(17):571–573. [PubMed] [Google Scholar]
  27. MENZIES J. S., COOPER W. F. The effect of triiodothyroacetate (triac) on serum cholesterol levels. Med J Aust. 1957 Apr 27;44(17):573–574. [PubMed] [Google Scholar]
  28. MONEY W. L., MELTZER R. I., FELDMAN D., RAWSON R. W. The effect of various thyroxine analogues on suppression of I 131 uptake by the rat thyroid. Endocrinology. 1959 Jan;64(1):123–125. doi: 10.1210/endo-64-1-123. [DOI] [PubMed] [Google Scholar]
  29. PITT-RIVERS R. Physiological activity of the acetic-acid analogues of some iodinated thyronines. Lancet. 1953 Aug 1;265(6779):234–235. doi: 10.1016/s0140-6736(53)90164-0. [DOI] [PubMed] [Google Scholar]
  30. RAWSON R. V., RALL J. E., PEARSON O. H., ROBBINS J., POPPELL H. F., WEST C. D. 1-Triiodothyronine versus 1-throxine; a comparison of their metabolic effects in human myxedema. Am J Med Sci. 1953 Oct;226(4):405–411. [PubMed] [Google Scholar]
  31. ROCHE J., LISSITZKY S., MICHEL R. Sur la présence de triiodothyronine dans la thyroglobuline. C R Hebd Seances Acad Sci. 1952 Mar 10;234(11):1228–1230. [PubMed] [Google Scholar]
  32. ROCHE J., MICHEL R., JOUAN P., WOLF W. Sur la formation de 3:3'-diiodothyronine et d'acide 3:5:3'-triiodothyroacétique à partir de la 3:5:3'-triiodothyronine chez le rat. C R Seances Soc Biol Fil. 1956;150(2):255–258. [PubMed] [Google Scholar]
  33. ROCHE J., MICHEL R., JOUAN P., WOLF W. Sur la présence de l'acide 3.5.3'-triiodothyroacétique dans le rein de rats après administration de 3.5.3'. L-triiodothyronine. C R Hebd Seances Acad Sci. 1955 Dec 14;241(24):1880–1882. [PubMed] [Google Scholar]
  34. ROCHE J., MICHEL R., JOUAN P., WOLF W. Sur la présence de l'acide 3: 5: 3' -triiodothyroacétique et de la 3: 3' -diiodothyronine dans le rein du rat après injection de 3: 5: 3' -triiodothyronine et premières données sur le métabolisme de l'acide 3: 5: 3' -triiodothyroacétique. Ann Pharm Fr. 1956 Mar;14(3):161–171. [PubMed] [Google Scholar]
  35. ROCHE J., MICHEL R., TRUCHOT R., WOLF W., MICHEL O. Sur les activités biologiques des iodothyronines et de divers analogues structuraux des hormones thyroïdiennes. Biochim Biophys Acta. 1956 May;20(2):337–344. doi: 10.1016/0006-3002(56)90294-3. [DOI] [PubMed] [Google Scholar]
  36. SELENKOW H. A., ASPER S. P., Jr The effectiveness of triiodothyronine or thyroxine administered orally in the treatment of myxedema. J Clin Endocrinol Metab. 1955 Mar;15(3):285–296. doi: 10.1210/jcem-15-3-285. [DOI] [PubMed] [Google Scholar]
  37. STARR P., SNIPES G., LIEBHOLDSCHUECK R. Biologic effects of triiodothyronine in human subjects. J Clin Endocrinol Metab. 1955 Jan;15(1):98–106. doi: 10.1210/jcem-15-1-98. [DOI] [PubMed] [Google Scholar]
  38. STASILLI N. R., KROC R. L., MELTZER R. I. Antigoitrogenic and calorigenic activities of thyroxine analogues in rats. Endocrinology. 1959 Jan;64(1):62–82. doi: 10.1210/endo-64-1-62. [DOI] [PubMed] [Google Scholar]
  39. THIBAULT O. Action de l'acide triiodothyroacétique sur le métabolisme de base du rat éthyroidé. Ann Endocrinol (Paris) 1956 May;17(1):35–42. [PubMed] [Google Scholar]
  40. THIBAULT O. Action des dérivés acétiques des hormones thyroïdiennes sur le métabolisme de base du rat éthyroïdé. Arch Sci Physiol (Paris) 1956;10(4):423–446. [PubMed] [Google Scholar]
  41. THIBAULT O., PITT-RIVERS R. Immediate effects of thyroxine analogues on biological oxidations in vitro. Lancet. 1955 Feb 5;268(6858):285–286. doi: 10.1016/s0140-6736(55)90111-2. [DOI] [PubMed] [Google Scholar]
  42. TROTTER W. R. Effect of triiodothyroacetic acid in a case of myxoedema. Lancet. 1955 Aug 20;269(6886):374–375. doi: 10.1016/s0140-6736(55)92356-4. [DOI] [PubMed] [Google Scholar]
  43. TROTTER W. R. Effect of triiodothyroacetic acid on blood-cholesterol levels. Lancet. 1956 Jun 9;270(6928):885–889. doi: 10.1016/s0140-6736(56)91347-2. [DOI] [PubMed] [Google Scholar]
  44. TROTTER W. R. Effect of triiodothyroacetic acid on blood-cholesterol levels. Lancet. 1956 Jun 9;270(6928):885–889. doi: 10.1016/s0140-6736(56)91347-2. [DOI] [PubMed] [Google Scholar]
  45. WISWELL J. G., ASPER S. P., Jr Studies of thyroxine and some of its analogues. V. Metabolic activity in vitro and in vivo of the acetic acid analogues of triiodothyronine and thyroxine. Bull Johns Hopkins Hosp. 1958 Mar;102(3):115–126. [PubMed] [Google Scholar]

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