Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1960 Mar;39(3):534–553. doi: 10.1172/JCI104067

CLINICAL, MORPHOLOGICAL AND BIOCHEMICAL STUDIES OF A VIRILIZING TUMOR IN THE TESTIS*

Kenneth Savard 1,2,3,4,5,†, Ralph I Dorfman 1,2,3,4,5, Billy Baggett 1,2,3,4,5,‡, Linda L Fielding 1,2,3,4,5, Lewis L Engel 1,2,3,4,5,§, Harry T McPherson 1,2,3,4,5, Leonard M Lister 1,2,3,4,5,ǁ, David S Johnson 1,2,3,4,5,, Edwin C Hamblen 1,2,3,4,5, Frank L Engel 1,2,3,4,5
PMCID: PMC293334  PMID: 14442011

Full text

PDF
534

Images in this article

535Image
on p.535
535Image
on p.535
536Image
on p.536
536Image
on p.536
537Image
on p.537
537Image
on p.537

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANAGNOSTOU J., FRANGOPOLUS G. J. Pubertas praecox caused by interstitial-cell tumour of testicle. Br Med J. 1953 Apr 18;1(4815):861–862. doi: 10.1136/bmj.1.4815.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BAGGETT B., DORFMAN R. I., ENGEL L. L., SAVARD K. The conversion of testosterone-3-C14 to C14-estradiol-17beta by human ovarian tissue. J Biol Chem. 1956 Aug;221(2):931–941. [PubMed] [Google Scholar]
  3. BAGGETT B., ENGEL L. L., FIELDING L. L. The estimation of hydroxysteroids. J Biol Chem. 1955 Mar;213(1):87–97. [PubMed] [Google Scholar]
  4. BAGGETT B., ENGEL L. L. The use of countercurrent distribution for the study of radiochemical purity. J Biol Chem. 1957 Nov;229(1):443–450. [PubMed] [Google Scholar]
  5. BLOCH E., DORFMAN R. I., PINCUS G. Presence of 17-ketosteroids in adrenal perfusates. Proc Soc Exp Biol Med. 1954 Jan;85(1):106–110. doi: 10.3181/00379727-85-20800. [DOI] [PubMed] [Google Scholar]
  6. BROWN R., LYNN W. S. Mechanism of in vitro steroid oxidation. Biochim Biophys Acta. 1956 Aug;21(2):403–405. doi: 10.1016/0006-3002(56)90042-7. [DOI] [PubMed] [Google Scholar]
  7. BURTON R. B., ZAFFARONI, KEUTMANN E. H. Paper chromatography of steroids. II. Corticosteroids and related compounds. J Biol Chem. 1951 Feb;188(2):763–771. [PubMed] [Google Scholar]
  8. BUSH I. E. Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. Biochem J. 1952 Jan;50(3):370–378. doi: 10.1042/bj0500370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. COOK C. D., GROSS R. E., LANDING B. H., ZYGMUNTOWICZ A. S. Interstitial cell tumor of the testis; study of a 5-year-old boy with pseudo-precocious puberty. J Clin Endocrinol Metab. 1952 Jun;12(6):725–734. doi: 10.1210/jcem-12-6-725. [DOI] [PubMed] [Google Scholar]
  10. Cohen H. Hyperplasia of the Adrenal Cortex Associated with Bilateral Testicular Tumors. Am J Pathol. 1946 Jan;22(1):157–173. [PMC free article] [PubMed] [Google Scholar]
  11. DYRENFORTH L. Y., JUNGCK E. C., KNIGHT A. M., Jr, OHLMACHER A. P., THRASH A. M. Sexual precocity due to interstitial-cell tumor of the testis: report of 2 cases. J Clin Endocrinol Metab. 1957 Feb;17(2):291–295. doi: 10.1210/jcem-17-2-291. [DOI] [PubMed] [Google Scholar]
  12. ENGEL L. L., SLAUNWHITE W. R., Jr, CARTER P., NATHANSON I. T. The separation of natural estrogens by countercurrent distribution. J Biol Chem. 1950 Jul;185(1):255–263. [PubMed] [Google Scholar]
  13. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  14. GARVEY F. K., DANIEL T. B. Bilateral interstitial cell tumor of the testicle. J Urol. 1951 Nov;66(5):713–719. doi: 10.1016/S0022-5347(17)74404-7. [DOI] [PubMed] [Google Scholar]
  15. HAYANO M., DORFMAN R. I. The enzymatic C-11 beta-hydroxylation of steroids. J Biol Chem. 1953 Mar;201(1):175–188. [PubMed] [Google Scholar]
  16. HAYANO M., LINDBERG M. C., WIENER M., ROSENKRANTZ H., DORFMAN R. I. Steroid transformations by corpus luteum tissue. Endocrinology. 1954 Sep;55(3):326–331. doi: 10.1210/endo-55-3-326. [DOI] [PubMed] [Google Scholar]
  17. HEDINGER C. Beidseitige Hodentumoren und kongenitales adrenogenitales Syndrom; Leydig-Zellen oder Nebennierenrindengewebe? Schweiz Z Pathol Bakteriol. 1954;17(6):743–750. [PubMed] [Google Scholar]
  18. HERTZ R., COHEN M. I., LEWIS L. G., FIRMINGER H. I. Sexual precocity in a 5-year-old boy with interstitial-cell tumor of the testis. J Clin Endocrinol Metab. 1953 Oct;13(10):1248–1253. doi: 10.1210/jcem-13-10-1248. [DOI] [PubMed] [Google Scholar]
  19. HUBENER H. J., FUKUSHIMA D. K., GALLAGHER T. F. Substrate specificity of enzymes reducing the 11- and 20-keto groups of steroids. J Biol Chem. 1956 Jun;220(2):499–511. [PubMed] [Google Scholar]
  20. JAMES D. C., SHUPE R. D. Interstitial cell tumor of the testicle with report of a case. J Urol. 1950 Apr;63(4):718–723. doi: 10.1016/S0022-5347(17)68817-7. [DOI] [PubMed] [Google Scholar]
  21. KOCHAKIAN C. D., STIDWORTHY G. Paper chromatography of C19 steroids. J Biol Chem. 1952 Dec;199(2):607–612. [PubMed] [Google Scholar]
  22. MELICOW M. M., ROBINSON J. N. Interstitial cell tumors of testis; review of literature and report of case; discussion of gynecomastia and testosterone; incidence in animals and experimental production of interstitial cell tumors. J Urol. 1949 Nov;62(5):672–693. doi: 10.1016/S0022-5347(17)68987-0. [DOI] [PubMed] [Google Scholar]
  23. NEHER R., WETTSTEIN A. Physicochemical detection and measurement of aldosterone in body fluids and tissues. Acta Endocrinol (Copenh) 1955 Apr;18(4):386–395. doi: 10.1530/acta.0.0180386. [DOI] [PubMed] [Google Scholar]
  24. NEWNS G. H. Precocious sexual development due to an interstitial-cell tumour of the testis. Br J Surg. 1952 Jan;39(156):379–381. doi: 10.1002/bjs.18003915632. [DOI] [PubMed] [Google Scholar]
  25. POMER F. A., STILES R. E., GRAHAM J. H. Interstitial-cell tumors of the testis in children; report of a case and review of the literature. N Engl J Med. 1954 Feb 11;250(6):233–237. doi: 10.1056/NEJM195402112500602. [DOI] [PubMed] [Google Scholar]
  26. REZED P., HARDIN H. C., Jr Bilateral interstitial cell tumor of the testicle: report of one case observed fourteen years. J Urol. 1955 Nov;74(5):628–635. doi: 10.1016/S0022-5347(17)67330-0. [DOI] [PubMed] [Google Scholar]
  27. RICHARDSON E. M., TOUCHSTONE J. C., DOHAN F. C. Urinary alpha-ketolic steroid metabolites of cortical hormones administered to subjects with adrenal cortical insufficiency. J Clin Invest. 1955 Feb;34(2):285–301. doi: 10.1172/JCI103082. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. ROSENKRANTZ H. An antimony trichloride reagent suitable for the detection and estimation of nonketonic steroids. Arch Biochem Biophys. 1953 May;44(1):1–8. doi: 10.1016/0003-9861(53)90002-2. [DOI] [PubMed] [Google Scholar]
  29. SAVARD K., BURSTEIN S., ROSENKRANTZ H., DORFMAN R. I. The metabolism of adrenosterone in vivo. J Biol Chem. 1953 Jun;202(2):717–725. [PubMed] [Google Scholar]
  30. SAVARD K. Paper partition chromatography of C19-and C21-ketosteroids. J Biol Chem. 1953 May;202(1):457–477. [PubMed] [Google Scholar]
  31. SILBER R. H., PORTER C. C. The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma. J Biol Chem. 1954 Oct;210(2):923–932. [PubMed] [Google Scholar]
  32. SLAUNWHITE W. R., Jr, SAMUELS L. T. Progesterone as a precursor of testicular androgens. J Biol Chem. 1956 May;220(1):341–352. [PubMed] [Google Scholar]
  33. STAUBITZ W. J., OBERKIRCHER O. J., BLICK M. S. Precocious puberty in a case of bilateral interstitial cell tumor of the testes. J Urol. 1953 Apr;69(4):562–570. doi: 10.1016/S0022-5347(17)68113-8. [DOI] [PubMed] [Google Scholar]
  34. STERNBERG W. H., SEGALOFF A., GASKILL C. J. Influence of chorionic gonadotropin on human ovarian hilus cells, Leydig-like cells. J Clin Endocrinol Metab. 1953 Feb;13(2):139–153. doi: 10.1210/jcem-13-2-139. [DOI] [PubMed] [Google Scholar]
  35. THAMDRUP E. Macrogenitosomia caused by interstitial cell tumour of the testis; a case in a 7 1/2-year-old boy. Acta Paediatr. 1953 Jul;42(4):369–377. doi: 10.1111/j.1651-2227.1953.tb05607.x. [DOI] [PubMed] [Google Scholar]
  36. WEST C. D., DAMAST B. L., SARRO S. D., PEARSON O. H. Conversion of testosterone to estrogens in castrated, adrenalectomized human females. J Biol Chem. 1956 Jan;218(1):409–418. [PubMed] [Google Scholar]
  37. WETTSTEIN A. Advances in the field of adrenal cortical hormones. Experientia. 1954 Oct 15;10(10):397–416. doi: 10.1007/BF02318502. [DOI] [PubMed] [Google Scholar]
  38. WIEST W. G. The metabolism of progesterone to delta4-pregnen-20alpha-ol-3-one in eviscerated female rats. J Biol Chem. 1956 Jul;221(1):461–467. [PubMed] [Google Scholar]
  39. WILKINS L., CARA J. Further studies on the treatment of congenital adrenal hyperplasia with cortisone. V. Effects of cortisone therapy on testicular development. J Clin Endocrinol Metab. 1954 Mar;14(3):287–296. doi: 10.1210/jcem-14-3-287. [DOI] [PubMed] [Google Scholar]
  40. WOTIZ H. H., DAVIS J. W., LEMON H. M. Steroid biosynthesis by surviving testicular tumor tissue. J Biol Chem. 1955 Oct;216(2):677–687. [PubMed] [Google Scholar]
  41. ZAFFARONI A., BURTON R. B. Identification of corticosteroids of beef adrenal extract by paper chromatography. J Biol Chem. 1951 Dec;193(2):749–767. [PubMed] [Google Scholar]
  42. ZANDER J., FORBES T. R., VON MUNSTERMANN A. M., NEHER R. Delta 4-3-Ketopregnene-20 alpha-ol and delta 4-3-ketopregnene-20 beta-ol, two naturally occurring metabolites of progesterone; isolation, identification, biologic activity and concentration in human tissues. J Clin Endocrinol Metab. 1958 Apr;18(4):337–353. doi: 10.1210/jcem-18-4-337. [DOI] [PubMed] [Google Scholar]
  43. ZANDER J. Steroids in the human ovary. J Biol Chem. 1958 May;232(1):117–122. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES